KR100862178B1 - 라파마이신과 겜시타빈 또는 플루오로우라실과의 항신생물제 배합물 - Google Patents

라파마이신과 겜시타빈 또는 플루오로우라실과의 항신생물제 배합물 Download PDF

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KR100862178B1
KR100862178B1 KR1020037013090A KR20037013090A KR100862178B1 KR 100862178 B1 KR100862178 B1 KR 100862178B1 KR 1020037013090 A KR1020037013090 A KR 1020037013090A KR 20037013090 A KR20037013090 A KR 20037013090A KR 100862178 B1 KR100862178 B1 KR 100862178B1
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cancer
gemcitabine
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cci
fluorouracil
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Korean (ko)
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KR20040007491A (ko
Inventor
기봉스제임스조셉쥬니어
듀카트게리
프리슈유르겐헤르만에른스트
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와이어쓰
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020037013090A 2001-04-06 2002-04-05 라파마이신과 겜시타빈 또는 플루오로우라실과의 항신생물제 배합물 Expired - Fee Related KR100862178B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28238801P 2001-04-06 2001-04-06
US28238501P 2001-04-06 2001-04-06
US60/282,388 2001-04-06
US60/282,385 2001-04-06
PCT/US2002/010912 WO2002080975A1 (en) 2001-04-06 2002-04-05 Antineoplastic combinations such as rapamycin together with gemcitabine or fluorouracil

Publications (2)

Publication Number Publication Date
KR20040007491A KR20040007491A (ko) 2004-01-24
KR100862178B1 true KR100862178B1 (ko) 2008-10-09

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EP (1) EP1385551B1 (cg-RX-API-DMAC7.html)
JP (1) JP2004525950A (cg-RX-API-DMAC7.html)
KR (1) KR100862178B1 (cg-RX-API-DMAC7.html)
CN (1) CN1309421C (cg-RX-API-DMAC7.html)
AT (1) ATE406892T1 (cg-RX-API-DMAC7.html)
AU (1) AU2007242958A1 (cg-RX-API-DMAC7.html)
BR (1) BR0208627A (cg-RX-API-DMAC7.html)
CA (1) CA2442849A1 (cg-RX-API-DMAC7.html)
DE (1) DE60228699D1 (cg-RX-API-DMAC7.html)
EA (1) EA010184B1 (cg-RX-API-DMAC7.html)
ES (1) ES2312568T3 (cg-RX-API-DMAC7.html)
HU (1) HUP0304093A3 (cg-RX-API-DMAC7.html)
IL (1) IL157898A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA03009092A (cg-RX-API-DMAC7.html)
NO (1) NO20034433L (cg-RX-API-DMAC7.html)
NZ (1) NZ540047A (cg-RX-API-DMAC7.html)
PL (1) PL363991A1 (cg-RX-API-DMAC7.html)
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JP5368096B2 (ja) 2006-08-28 2013-12-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 未分化型胃癌に対する抗腫瘍剤
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CN101616671A (zh) 2007-01-19 2009-12-30 卫材R&D管理有限公司 胰腺癌治疗用组合物
EP2119707B1 (en) 2007-01-29 2015-01-14 Eisai R&D Management Co., Ltd. Composition for treatment of undifferentiated-type of gastric cancer
RU2483714C2 (ru) * 2007-03-07 2013-06-10 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи. Наночастица, содержащая рапамицин и альбумин, в качестве противоракового агента
PT2155188E (pt) 2007-06-01 2013-12-19 Abraxis Bioscience Llc Métodos e composições para o tratamento de cancro recorrente
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US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
KR20000070351A (ko) * 1997-01-24 2000-11-25 앨린 앤더슨 젬시타빈 유도체

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Also Published As

Publication number Publication date
DE60228699D1 (de) 2008-10-16
ATE406892T1 (de) 2008-09-15
CN1545419A (zh) 2004-11-10
NO20034433L (no) 2003-11-25
NO20034433D0 (no) 2003-10-03
EP1385551B1 (en) 2008-09-03
ES2312568T3 (es) 2009-03-01
EA010184B1 (ru) 2008-06-30
CN1309421C (zh) 2007-04-11
CA2442849A1 (en) 2002-10-17
HK1060062A1 (en) 2004-07-30
BR0208627A (pt) 2004-03-09
SG152906A1 (en) 2009-06-29
PT1385551E (pt) 2008-11-03
WO2002080975A1 (en) 2002-10-17
HUP0304093A2 (hu) 2004-04-28
IL157898A0 (en) 2004-03-28
JP2004525950A (ja) 2004-08-26
PL363991A1 (en) 2004-11-29
HUP0304093A3 (en) 2008-08-28
AU2007242958A1 (en) 2008-01-10
KR20040007491A (ko) 2004-01-24
EA200301091A1 (ru) 2004-02-26
NZ540047A (en) 2007-01-26
MXPA03009092A (es) 2004-02-12
EP1385551A1 (en) 2004-02-04
SI1385551T1 (sl) 2008-12-31

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Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20111002

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000