KR100860386B1 - 디카복실 유기산과의 아세틸 ｌ-카르니틴 염 및 이의 제조방법 - Google Patents

디카복실 유기산과의 아세틸 ｌ-카르니틴 염 및 이의 제조방법 Download PDF

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Publication number
KR100860386B1
KR100860386B1 KR1020047008307A KR20047008307A KR100860386B1 KR 100860386 B1 KR100860386 B1 KR 100860386B1 KR 1020047008307 A KR1020047008307 A KR 1020047008307A KR 20047008307 A KR20047008307 A KR 20047008307A KR 100860386 B1 KR100860386 B1 KR 100860386B1
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KR
South Korea
Prior art keywords
acetyl
carnitine
solution
acid fumarate
crystalline
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Expired - Fee Related
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KR1020047008307A
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English (en)
Korean (ko)
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KR20040064721A (ko
Inventor
알도 파씨
Original Assignee
시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이.
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Publication of KR20040064721A publication Critical patent/KR20040064721A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/02—Preparation of carboxylic acid esters by interreacting ester groups, i.e. transesterification

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020047008307A 2001-12-12 2002-11-25 디카복실 유기산과의 아세틸 ｌ-카르니틴 염 및 이의 제조방법 Expired - Fee Related KR100860386B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITRM2001A000729 2001-12-12
IT2001RM000729A ITRM20010729A1 (it) 2001-12-12 2001-12-12 Sale di acetil l-carnitina con un acido organico dicarbossilico e procedimento per la sua preparazione.
PCT/IT2002/000743 WO2003053911A1 (en) 2001-12-12 2002-11-25 Acetyl l-carnitine salt with a dicarboxilic organic acid and process for preparing same

Publications (2)

Publication Number Publication Date
KR20040064721A KR20040064721A (ko) 2004-07-19
KR100860386B1 true KR100860386B1 (ko) 2008-09-26

Family

ID=11455916

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047008307A Expired - Fee Related KR100860386B1 (ko) 2001-12-12 2002-11-25 디카복실 유기산과의 아세틸 ｌ-카르니틴 염 및 이의 제조방법

Country Status (18)

Country Link
US (1) US6673837B2 (https=)
EP (1) EP1453791B1 (https=)
JP (1) JP4902940B2 (https=)
KR (1) KR100860386B1 (https=)
CN (1) CN1250521C (https=)
AT (1) ATE457300T1 (https=)
AU (1) AU2002358989A1 (https=)
CA (1) CA2468234C (https=)
CY (1) CY1110684T1 (https=)
DE (1) DE60235318D1 (https=)
DK (1) DK1453791T3 (https=)
ES (1) ES2339432T3 (https=)
HU (1) HU230034B1 (https=)
IT (1) ITRM20010729A1 (https=)
PL (1) PL207877B1 (https=)
PT (1) PT1453791E (https=)
SI (1) SI1453791T1 (https=)
WO (1) WO2003053911A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8173618B2 (en) * 2003-07-25 2012-05-08 University Of Massachusetts Formulations for reducing neuronal degeneration
CN101209975B (zh) * 2006-12-29 2010-12-01 沈阳科硕营养科技有限公司 左旋肉碱富马酸钙及其制备方法与用途
US8597640B2 (en) * 2007-10-31 2013-12-03 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging
JP2012092036A (ja) * 2010-10-26 2012-05-17 Mitsubishi Rayon Co Ltd カルニチンの塩の製造方法
BR112014003459A2 (pt) * 2011-08-31 2017-03-01 Procter & Gamble elemento de fixação tendo camada de reforço ligada
JP5933383B2 (ja) * 2012-07-26 2016-06-08 ロート製薬株式会社 内服用固形製剤の吸湿性・流動性の改善方法、吸湿性・流動性が改善されてなる内服用固形製剤、及び該内服用固形製剤の製造法
JP6100939B2 (ja) * 2016-02-26 2017-03-22 ロート製薬株式会社 内服用固形製剤の吸湿性・流動性の改善方法、吸湿性・流動性が改善されてなる内服用固形製剤、及び該内服用固形製剤の製造法
JP6964876B2 (ja) * 2017-11-27 2021-11-10 株式会社古川リサーチオフィス オロット酸−カルニチン混合体粉体又はフマル酸−カルニチン混合体粉体の製造方法
CN119351483B (zh) * 2024-12-03 2025-05-30 北京佰依源生物科技有限公司 一种长碳链二元酸生产强度提高的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602039A (en) * 1983-12-28 1986-07-22 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Salts of-carnitine and alkanoyl L-carnitines and process for preparing same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602039A (en) * 1983-12-28 1986-07-22 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Salts of-carnitine and alkanoyl L-carnitines and process for preparing same

Also Published As

Publication number Publication date
KR20040064721A (ko) 2004-07-19
EP1453791B1 (en) 2010-02-10
SI1453791T1 (sl) 2010-11-30
JP4902940B2 (ja) 2012-03-21
ATE457300T1 (de) 2010-02-15
HUP0402545A3 (en) 2012-09-28
CN1602294A (zh) 2005-03-30
JP2005513122A (ja) 2005-05-12
EP1453791A1 (en) 2004-09-08
CN1250521C (zh) 2006-04-12
CA2468234A1 (en) 2003-07-03
PL371130A1 (en) 2005-06-13
WO2003053911A1 (en) 2003-07-03
CY1110684T1 (el) 2015-06-10
CA2468234C (en) 2010-02-23
PL207877B1 (pl) 2011-02-28
ES2339432T3 (es) 2010-05-20
HUP0402545A2 (hu) 2005-04-28
AU2002358989A1 (en) 2003-07-09
US20030119904A1 (en) 2003-06-26
DK1453791T3 (da) 2010-05-25
HU230034B1 (hu) 2015-05-28
HK1073295A1 (en) 2005-09-30
DE60235318D1 (de) 2010-03-25
ITRM20010729A1 (it) 2003-06-12
PT1453791E (pt) 2010-04-14
US6673837B2 (en) 2004-01-06

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