KR100856996B1 - 디아릴메틸피페라진 유도체의 신규한 비대칭 제조 방법 및중간체로서의 신규한 비대칭 디아릴메틸아민 - Google Patents
디아릴메틸피페라진 유도체의 신규한 비대칭 제조 방법 및중간체로서의 신규한 비대칭 디아릴메틸아민 Download PDFInfo
- Publication number
- KR100856996B1 KR100856996B1 KR1020037011675A KR20037011675A KR100856996B1 KR 100856996 B1 KR100856996 B1 KR 100856996B1 KR 1020037011675 A KR1020037011675 A KR 1020037011675A KR 20037011675 A KR20037011675 A KR 20037011675A KR 100856996 B1 KR100856996 B1 KR 100856996B1
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- methyl
- reacting
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *C(c(cc1)ccc1C(N(*)*)=C)N(CC1)CCN1S(c(cccc1)c1[N+]([O-])=O)(=O)=O Chemical compound *C(c(cc1)ccc1C(N(*)*)=C)N(CC1)CCN1S(c(cccc1)c1[N+]([O-])=O)(=O)=O 0.000 description 6
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Quinoline Compounds (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0100764A SE0100764D0 (sv) | 2001-03-07 | 2001-03-07 | New assymetric process |
| SE0100764-0 | 2001-03-07 | ||
| PCT/SE2002/000376 WO2002070492A1 (en) | 2001-03-07 | 2002-03-05 | New asymmetric process for the preparation of diarylmethylpiperazines derivatives and novel asymmetric diarylmetylamines as intermediates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20030080075A KR20030080075A (ko) | 2003-10-10 |
| KR100856996B1 true KR100856996B1 (ko) | 2008-09-04 |
Family
ID=20283236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020037011675A Expired - Fee Related KR100856996B1 (ko) | 2001-03-07 | 2002-03-05 | 디아릴메틸피페라진 유도체의 신규한 비대칭 제조 방법 및중간체로서의 신규한 비대칭 디아릴메틸아민 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7045625B2 (https=) |
| EP (1) | EP1368325B1 (https=) |
| JP (1) | JP2004522793A (https=) |
| KR (1) | KR100856996B1 (https=) |
| CN (2) | CN1295217C (https=) |
| AT (1) | ATE406354T1 (https=) |
| BR (1) | BR0207817A (https=) |
| CA (1) | CA2440104A1 (https=) |
| DE (1) | DE60228548D1 (https=) |
| DK (1) | DK1368325T3 (https=) |
| ES (1) | ES2311050T3 (https=) |
| IL (1) | IL157460A0 (https=) |
| MX (1) | MXPA03007889A (https=) |
| NO (1) | NO325156B1 (https=) |
| NZ (1) | NZ527656A (https=) |
| PT (1) | PT1368325E (https=) |
| SE (1) | SE0100764D0 (https=) |
| SI (1) | SI1368325T1 (https=) |
| WO (1) | WO2002070492A1 (https=) |
| ZA (1) | ZA200306448B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114560781A (zh) * | 2022-03-01 | 2022-05-31 | 无锡捷化医药科技有限公司 | 一种n,n-二(2-氯乙基)-4-硝基苯基丙氨酸甲酯的制备方法 |
| CN114702457A (zh) * | 2022-03-30 | 2022-07-05 | 青岛科技大学 | 一种二芳基甲胺类化合物的绿色合成方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001045637A2 (en) * | 1999-12-20 | 2001-06-28 | Astrazeneca Ab | Novel 4(piperazinyl (8-quinolinyl)metyl)benzamides |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| CN1054850C (zh) * | 1993-07-30 | 2000-07-26 | 德尔塔药物公司 | 用于治疗的哌嗪化合物 |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| SE0001209D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
-
2001
- 2001-03-07 SE SE0100764A patent/SE0100764D0/xx unknown
-
2002
- 2002-03-05 BR BR0207817-1A patent/BR0207817A/pt not_active IP Right Cessation
- 2002-03-05 CA CA002440104A patent/CA2440104A1/en not_active Abandoned
- 2002-03-05 US US10/468,989 patent/US7045625B2/en not_active Expired - Fee Related
- 2002-03-05 WO PCT/SE2002/000376 patent/WO2002070492A1/en not_active Ceased
- 2002-03-05 ES ES02701852T patent/ES2311050T3/es not_active Expired - Lifetime
- 2002-03-05 NZ NZ527656A patent/NZ527656A/en unknown
- 2002-03-05 DE DE60228548T patent/DE60228548D1/de not_active Expired - Fee Related
- 2002-03-05 CN CNB2005100879382A patent/CN1295217C/zh not_active Expired - Fee Related
- 2002-03-05 SI SI200230739T patent/SI1368325T1/sl unknown
- 2002-03-05 IL IL15746002A patent/IL157460A0/xx unknown
- 2002-03-05 PT PT02701852T patent/PT1368325E/pt unknown
- 2002-03-05 KR KR1020037011675A patent/KR100856996B1/ko not_active Expired - Fee Related
- 2002-03-05 DK DK02701852T patent/DK1368325T3/da active
- 2002-03-05 AT AT02701852T patent/ATE406354T1/de not_active IP Right Cessation
- 2002-03-05 EP EP02701852A patent/EP1368325B1/en not_active Expired - Lifetime
- 2002-03-05 MX MXPA03007889A patent/MXPA03007889A/es active IP Right Grant
- 2002-03-05 CN CNB028060326A patent/CN1244565C/zh not_active Expired - Fee Related
- 2002-03-05 JP JP2002569812A patent/JP2004522793A/ja active Pending
-
2003
- 2003-08-19 ZA ZA200306448A patent/ZA200306448B/en unknown
- 2003-09-05 NO NO20033944A patent/NO325156B1/no not_active IP Right Cessation
-
2005
- 2005-11-22 US US11/285,672 patent/US7423154B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001045637A2 (en) * | 1999-12-20 | 2001-06-28 | Astrazeneca Ab | Novel 4(piperazinyl (8-quinolinyl)metyl)benzamides |
Also Published As
| Publication number | Publication date |
|---|---|
| IL157460A0 (en) | 2004-03-28 |
| EP1368325A1 (en) | 2003-12-10 |
| CN1721407A (zh) | 2006-01-18 |
| CA2440104A1 (en) | 2002-09-12 |
| SE0100764D0 (sv) | 2001-03-07 |
| NO20033944L (no) | 2003-10-31 |
| BR0207817A (pt) | 2004-03-09 |
| JP2004522793A (ja) | 2004-07-29 |
| WO2002070492A1 (en) | 2002-09-12 |
| ZA200306448B (en) | 2004-09-08 |
| NO325156B1 (no) | 2008-02-11 |
| CN1244565C (zh) | 2006-03-08 |
| ES2311050T3 (es) | 2009-02-01 |
| CN1295217C (zh) | 2007-01-17 |
| MXPA03007889A (es) | 2003-12-04 |
| US7045625B2 (en) | 2006-05-16 |
| EP1368325B1 (en) | 2008-08-27 |
| DK1368325T3 (da) | 2008-11-24 |
| KR20030080075A (ko) | 2003-10-10 |
| US20060074238A1 (en) | 2006-04-06 |
| US20040077861A1 (en) | 2004-04-22 |
| SI1368325T1 (sl) | 2008-12-31 |
| HK1059436A1 (en) | 2004-07-02 |
| NO20033944D0 (no) | 2003-09-05 |
| NZ527656A (en) | 2005-04-29 |
| ATE406354T1 (de) | 2008-09-15 |
| DE60228548D1 (de) | 2008-10-09 |
| PT1368325E (pt) | 2008-10-27 |
| US7423154B2 (en) | 2008-09-09 |
| CN1494532A (zh) | 2004-05-05 |
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St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
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St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
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| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
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| A201 | Request for examination | ||
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
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| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
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| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
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| E902 | Notification of reason for refusal | ||
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St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
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St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 20110830 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
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