BR0207817A - Processo para preparar um composto, e, composto - Google Patents
Processo para preparar um composto, e, compostoInfo
- Publication number
- BR0207817A BR0207817A BR0207817-1A BR0207817A BR0207817A BR 0207817 A BR0207817 A BR 0207817A BR 0207817 A BR0207817 A BR 0207817A BR 0207817 A BR0207817 A BR 0207817A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- synthesis
- chiral
- asymmetric
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Quinoline Compounds (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
"PROCESSO PARA PREPARAR UM COMPOSTO, E, COMPOSTO". é descrita uma síntese assimétrica de diarilmetilpiperazinas. A via sintética permite a preparação de uma variedade de aminas enanciomericamente puras com diferentes grupos N-alquila. A invenção inclui uma adição assimétrica de compostos organometálicos à sulfinimina quiral para fornecer adutos em predominantemente um diastereómero, que pode ser subseq³entemente transferido aos enanciómeros puros através de clivagem do auxiliar quiral, que é seguida pela síntese do anel piperazina através de procedimentos de alquilação.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0100764A SE0100764D0 (sv) | 2001-03-07 | 2001-03-07 | New assymetric process |
| PCT/SE2002/000376 WO2002070492A1 (en) | 2001-03-07 | 2002-03-05 | New asymmetric process for the preparation of diarylmethylpiperazines derivatives and novel asymmetric diarylmetylamines as intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0207817A true BR0207817A (pt) | 2004-03-09 |
Family
ID=20283236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0207817-1A BR0207817A (pt) | 2001-03-07 | 2002-03-05 | Processo para preparar um composto, e, composto |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7045625B2 (pt) |
| EP (1) | EP1368325B1 (pt) |
| JP (1) | JP2004522793A (pt) |
| KR (1) | KR100856996B1 (pt) |
| CN (2) | CN1295217C (pt) |
| AT (1) | ATE406354T1 (pt) |
| BR (1) | BR0207817A (pt) |
| CA (1) | CA2440104A1 (pt) |
| DE (1) | DE60228548D1 (pt) |
| DK (1) | DK1368325T3 (pt) |
| ES (1) | ES2311050T3 (pt) |
| HK (1) | HK1059436A1 (pt) |
| IL (1) | IL157460A0 (pt) |
| MX (1) | MXPA03007889A (pt) |
| NO (1) | NO325156B1 (pt) |
| NZ (1) | NZ527656A (pt) |
| PT (1) | PT1368325E (pt) |
| SE (1) | SE0100764D0 (pt) |
| SI (1) | SI1368325T1 (pt) |
| WO (1) | WO2002070492A1 (pt) |
| ZA (1) | ZA200306448B (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114560781A (zh) * | 2022-03-01 | 2022-05-31 | 无锡捷化医药科技有限公司 | 一种n,n-二(2-氯乙基)-4-硝基苯基丙氨酸甲酯的制备方法 |
| CN114702457A (zh) * | 2022-03-30 | 2022-07-05 | 青岛科技大学 | 一种二芳基甲胺类化合物的绿色合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| MY111348A (en) * | 1993-07-30 | 1999-11-30 | Ardent Pharmaceuticals Inc | Opioid diarylmethylpiperazines and piperidines |
| SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| SE9904673D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE0001209D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
-
2001
- 2001-03-07 SE SE0100764A patent/SE0100764D0/xx unknown
-
2002
- 2002-03-05 DK DK02701852T patent/DK1368325T3/da active
- 2002-03-05 PT PT02701852T patent/PT1368325E/pt unknown
- 2002-03-05 KR KR1020037011675A patent/KR100856996B1/ko not_active IP Right Cessation
- 2002-03-05 BR BR0207817-1A patent/BR0207817A/pt not_active IP Right Cessation
- 2002-03-05 WO PCT/SE2002/000376 patent/WO2002070492A1/en active IP Right Grant
- 2002-03-05 NZ NZ527656A patent/NZ527656A/en unknown
- 2002-03-05 EP EP02701852A patent/EP1368325B1/en not_active Expired - Lifetime
- 2002-03-05 CA CA002440104A patent/CA2440104A1/en not_active Abandoned
- 2002-03-05 CN CNB2005100879382A patent/CN1295217C/zh not_active Expired - Fee Related
- 2002-03-05 DE DE60228548T patent/DE60228548D1/de not_active Expired - Fee Related
- 2002-03-05 MX MXPA03007889A patent/MXPA03007889A/es active IP Right Grant
- 2002-03-05 JP JP2002569812A patent/JP2004522793A/ja active Pending
- 2002-03-05 US US10/468,989 patent/US7045625B2/en not_active Expired - Fee Related
- 2002-03-05 CN CNB028060326A patent/CN1244565C/zh not_active Expired - Fee Related
- 2002-03-05 ES ES02701852T patent/ES2311050T3/es not_active Expired - Lifetime
- 2002-03-05 IL IL15746002A patent/IL157460A0/xx unknown
- 2002-03-05 AT AT02701852T patent/ATE406354T1/de not_active IP Right Cessation
- 2002-03-05 SI SI200230739T patent/SI1368325T1/sl unknown
-
2003
- 2003-08-19 ZA ZA200306448A patent/ZA200306448B/en unknown
- 2003-09-05 NO NO20033944A patent/NO325156B1/no not_active IP Right Cessation
-
2004
- 2004-03-26 HK HK04102254.3A patent/HK1059436A1/xx not_active IP Right Cessation
-
2005
- 2005-11-22 US US11/285,672 patent/US7423154B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ527656A (en) | 2005-04-29 |
| KR100856996B1 (ko) | 2008-09-04 |
| WO2002070492A1 (en) | 2002-09-12 |
| US20040077861A1 (en) | 2004-04-22 |
| US20060074238A1 (en) | 2006-04-06 |
| NO20033944D0 (no) | 2003-09-05 |
| KR20030080075A (ko) | 2003-10-10 |
| NO325156B1 (no) | 2008-02-11 |
| SE0100764D0 (sv) | 2001-03-07 |
| EP1368325A1 (en) | 2003-12-10 |
| ZA200306448B (en) | 2004-09-08 |
| CN1494532A (zh) | 2004-05-05 |
| PT1368325E (pt) | 2008-10-27 |
| JP2004522793A (ja) | 2004-07-29 |
| DK1368325T3 (da) | 2008-11-24 |
| CN1295217C (zh) | 2007-01-17 |
| MXPA03007889A (es) | 2003-12-04 |
| SI1368325T1 (sl) | 2008-12-31 |
| US7423154B2 (en) | 2008-09-09 |
| ATE406354T1 (de) | 2008-09-15 |
| CA2440104A1 (en) | 2002-09-12 |
| CN1244565C (zh) | 2006-03-08 |
| CN1721407A (zh) | 2006-01-18 |
| EP1368325B1 (en) | 2008-08-27 |
| US7045625B2 (en) | 2006-05-16 |
| ES2311050T3 (es) | 2009-02-01 |
| DE60228548D1 (de) | 2008-10-09 |
| IL157460A0 (en) | 2004-03-28 |
| HK1059436A1 (en) | 2004-07-02 |
| NO20033944L (no) | 2003-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011. |