KR100853955B1 - 아크릴로일 디스타마이신 유도체 및 국소이성화효소 ⅰ 및ⅱ 억제제를 포함하는 약제학적 조성물 - Google Patents

아크릴로일 디스타마이신 유도체 및 국소이성화효소 ⅰ 및ⅱ 억제제를 포함하는 약제학적 조성물 Download PDF

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Publication number
KR100853955B1
KR100853955B1 KR1020027017440A KR20027017440A KR100853955B1 KR 100853955 B1 KR100853955 B1 KR 100853955B1 KR 1020027017440 A KR1020027017440 A KR 1020027017440A KR 20027017440 A KR20027017440 A KR 20027017440A KR 100853955 B1 KR100853955 B1 KR 100853955B1
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South Korea
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amino
methyl
carbonyl
pyrrole
group
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Korean (ko)
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KR20030019448A (ko
Inventor
제로니마리아크리스티나로사
코치파올로
베리아이탈로
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네르비아노 메디칼 사이언시스 에스.알.엘.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020027017440A 2000-06-23 2001-06-20 아크릴로일 디스타마이신 유도체 및 국소이성화효소 ⅰ 및ⅱ 억제제를 포함하는 약제학적 조성물 Expired - Fee Related KR100853955B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0015444.3 2000-06-23
GBGB0015444.3A GB0015444D0 (en) 2000-06-23 2000-06-23 Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
PCT/EP2001/007059 WO2001097789A2 (en) 2000-06-23 2001-06-20 Pharmaceutical compositions comprising acryloyl distamycin derivatives and topoisomerase i and ii inhibitors

Publications (2)

Publication Number Publication Date
KR20030019448A KR20030019448A (ko) 2003-03-06
KR100853955B1 true KR100853955B1 (ko) 2008-08-25

Family

ID=9894285

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027017440A Expired - Fee Related KR100853955B1 (ko) 2000-06-23 2001-06-20 아크릴로일 디스타마이신 유도체 및 국소이성화효소 ⅰ 및ⅱ 억제제를 포함하는 약제학적 조성물

Country Status (27)

Country Link
US (1) US20030162722A1 (enExample)
EP (1) EP1292290B1 (enExample)
JP (1) JP2003535890A (enExample)
KR (1) KR100853955B1 (enExample)
CN (1) CN1241573C (enExample)
AT (1) ATE323483T1 (enExample)
AU (2) AU2001278463B2 (enExample)
BR (1) BR0111813A (enExample)
CA (1) CA2411172C (enExample)
CZ (1) CZ20024155A3 (enExample)
DE (1) DE60118914T2 (enExample)
DK (1) DK1292290T3 (enExample)
EA (1) EA006684B1 (enExample)
EE (1) EE05319B1 (enExample)
ES (1) ES2261448T3 (enExample)
GB (1) GB0015444D0 (enExample)
HK (1) HK1054334B (enExample)
HU (1) HUP0301257A2 (enExample)
IL (1) IL153177A0 (enExample)
MX (1) MXPA02012163A (enExample)
NO (1) NO329783B1 (enExample)
NZ (1) NZ523000A (enExample)
PL (1) PL200503B1 (enExample)
PT (1) PT1292290E (enExample)
SK (1) SK287549B6 (enExample)
WO (1) WO2001097789A2 (enExample)
ZA (1) ZA200209834B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
DK1461083T3 (da) * 2002-01-02 2006-07-10 Nerviano Medical Sciences Srl Kombineret terapi mod tumorer omfattende substitueret acryloyl distamycinderivater og proteinkinase- (serin/threoninkinase) inhibitorer
CN100438913C (zh) * 2004-11-22 2008-12-03 山东蓝金生物工程有限公司 一种抗癌药物组合物
MD36Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
MD23Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare
MD24Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
MD35Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
AU2011274229A1 (en) 2010-07-02 2013-01-10 Angiochem Inc. Short and D-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
CN109718228A (zh) * 2017-10-30 2019-05-07 沈阳药科大学 米托蒽醌的抗肿瘤淋巴转移作用及其药物制剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004524A1 (en) * 1996-07-25 1998-02-05 Pharmacia & Upjohn S.P.A. Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
WO1998021202A1 (en) 1996-11-11 1998-05-22 Pharmacia & Upjohn S.P.A. Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9727524D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
GB9806692D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004524A1 (en) * 1996-07-25 1998-02-05 Pharmacia & Upjohn S.P.A. Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
WO1998021202A1 (en) 1996-11-11 1998-05-22 Pharmacia & Upjohn S.P.A. Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents

Also Published As

Publication number Publication date
NO20026078L (no) 2002-12-18
EA006684B1 (ru) 2006-02-24
HK1054334B (zh) 2006-09-22
CN1437474A (zh) 2003-08-20
SK18332002A3 (sk) 2003-07-01
CA2411172C (en) 2009-11-17
NZ523000A (en) 2005-12-23
GB0015444D0 (en) 2000-08-16
DE60118914T2 (de) 2006-12-21
WO2001097789A3 (en) 2002-05-16
EP1292290B1 (en) 2006-04-19
AU2001278463B2 (en) 2006-02-23
EE200200681A (et) 2004-06-15
KR20030019448A (ko) 2003-03-06
PL200503B1 (pl) 2009-01-30
CZ20024155A3 (cs) 2003-04-16
US20030162722A1 (en) 2003-08-28
PL360297A1 (en) 2004-09-06
EE05319B1 (et) 2010-08-16
HK1054334A1 (en) 2003-11-28
NO329783B1 (no) 2010-12-13
NO20026078D0 (no) 2002-12-18
CA2411172A1 (en) 2001-12-27
HUP0301257A2 (hu) 2003-08-28
PT1292290E (pt) 2006-08-31
IL153177A0 (en) 2003-06-24
SK287549B6 (sk) 2011-01-04
ATE323483T1 (de) 2006-05-15
EP1292290A2 (en) 2003-03-19
DE60118914D1 (de) 2006-05-24
ZA200209834B (en) 2003-12-04
AU7846301A (en) 2002-01-02
ES2261448T3 (es) 2006-11-16
BR0111813A (pt) 2003-05-20
MXPA02012163A (es) 2003-04-25
EA200300060A1 (ru) 2003-04-24
DK1292290T3 (da) 2006-07-10
CN1241573C (zh) 2006-02-15
WO2001097789A2 (en) 2001-12-27
JP2003535890A (ja) 2003-12-02

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