CN1437474A - 含有丙烯酰司他霉素衍生物以及拓扑异构酶ⅰ和ⅱ抑制剂的药物组合物 - Google Patents
含有丙烯酰司他霉素衍生物以及拓扑异构酶ⅰ和ⅱ抑制剂的药物组合物 Download PDFInfo
- Publication number
- CN1437474A CN1437474A CN01811639A CN01811639A CN1437474A CN 1437474 A CN1437474 A CN 1437474A CN 01811639 A CN01811639 A CN 01811639A CN 01811639 A CN01811639 A CN 01811639A CN 1437474 A CN1437474 A CN 1437474A
- Authority
- CN
- China
- Prior art keywords
- amino
- isophthalic acid
- pyrroles
- methyl isophthalic
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
化合物 | 治疗2方案 | 剂量(mg/kg/天) | ILS%3 | Tox4 |
PNU 166196 | iv+1 | 0.52 | 33 | 0/10 |
阿霉素 | iv+1(*) | 10 | 58 | 0/10 |
PNU 166196+阿霉素 | iv+1iv+1(*) | 0.52+10 | 100 | 0/10 |
Claims (22)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0015444.3A GB0015444D0 (en) | 2000-06-23 | 2000-06-23 | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors |
GB0015444.3 | 2000-06-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1437474A true CN1437474A (zh) | 2003-08-20 |
CN1241573C CN1241573C (zh) | 2006-02-15 |
Family
ID=9894285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018116396A Expired - Fee Related CN1241573C (zh) | 2000-06-23 | 2001-06-20 | 含有丙烯酰司他霉素衍生物以及拓扑异构酶ⅰ和ⅱ抑制剂的药物组合物 |
Country Status (27)
Country | Link |
---|---|
US (1) | US20030162722A1 (zh) |
EP (1) | EP1292290B1 (zh) |
JP (1) | JP2003535890A (zh) |
KR (1) | KR100853955B1 (zh) |
CN (1) | CN1241573C (zh) |
AT (1) | ATE323483T1 (zh) |
AU (2) | AU7846301A (zh) |
BR (1) | BR0111813A (zh) |
CA (1) | CA2411172C (zh) |
CZ (1) | CZ20024155A3 (zh) |
DE (1) | DE60118914T2 (zh) |
DK (1) | DK1292290T3 (zh) |
EA (1) | EA006684B1 (zh) |
EE (1) | EE05319B1 (zh) |
ES (1) | ES2261448T3 (zh) |
GB (1) | GB0015444D0 (zh) |
HK (1) | HK1054334B (zh) |
HU (1) | HUP0301257A2 (zh) |
IL (1) | IL153177A0 (zh) |
MX (1) | MXPA02012163A (zh) |
NO (1) | NO329783B1 (zh) |
NZ (1) | NZ523000A (zh) |
PL (1) | PL200503B1 (zh) |
PT (1) | PT1292290E (zh) |
SK (1) | SK287549B6 (zh) |
WO (1) | WO2001097789A2 (zh) |
ZA (1) | ZA200209834B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100438913C (zh) * | 2004-11-22 | 2008-12-03 | 山东蓝金生物工程有限公司 | 一种抗癌药物组合物 |
CN109718228A (zh) * | 2017-10-30 | 2019-05-07 | 沈阳药科大学 | 米托蒽醌的抗肿瘤淋巴转移作用及其药物制剂 |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0015447D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
GB0015444D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors |
ATE321572T1 (de) * | 2002-01-02 | 2006-04-15 | Pharmacia Italia Spa | Kombinierte tumortherapie auf der basis von substituierten acryloyl-distamycin-derivaten und protein-kinase (serin/threonin-kinase) inhibitoren |
MD36Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare |
MD35Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare |
MD24Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare |
MD23Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare |
JP2013530993A (ja) | 2010-07-02 | 2013-08-01 | アンジオケム インコーポレーテッド | 治療用コンジュゲートのための短く且つd−アミノ酸を含有するポリペプチドおよびその使用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9615692D0 (en) * | 1996-07-25 | 1996-09-04 | Pharmacia Spa | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
GB9623522D0 (en) * | 1996-11-11 | 1997-01-08 | Pharmacia & Upjohn Spa | Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents |
GB9727524D0 (en) * | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Synergistic antitumor composition containing a biologically active ureido compound |
GB9806692D0 (en) * | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents |
GB0015444D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors |
-
2000
- 2000-06-23 GB GBGB0015444.3A patent/GB0015444D0/en not_active Ceased
-
2001
- 2001-06-20 KR KR1020027017440A patent/KR100853955B1/ko not_active IP Right Cessation
- 2001-06-20 SK SK1833-2002A patent/SK287549B6/sk not_active IP Right Cessation
- 2001-06-20 AU AU7846301A patent/AU7846301A/xx active Pending
- 2001-06-20 PT PT01956495T patent/PT1292290E/pt unknown
- 2001-06-20 PL PL360297A patent/PL200503B1/pl not_active IP Right Cessation
- 2001-06-20 AT AT01956495T patent/ATE323483T1/de not_active IP Right Cessation
- 2001-06-20 EA EA200300060A patent/EA006684B1/ru not_active IP Right Cessation
- 2001-06-20 ES ES01956495T patent/ES2261448T3/es not_active Expired - Lifetime
- 2001-06-20 EP EP01956495A patent/EP1292290B1/en not_active Expired - Lifetime
- 2001-06-20 EE EEP200200681A patent/EE05319B1/xx not_active IP Right Cessation
- 2001-06-20 CZ CZ20024155A patent/CZ20024155A3/cs unknown
- 2001-06-20 WO PCT/EP2001/007059 patent/WO2001097789A2/en active IP Right Grant
- 2001-06-20 DE DE60118914T patent/DE60118914T2/de not_active Expired - Lifetime
- 2001-06-20 JP JP2002503266A patent/JP2003535890A/ja not_active Abandoned
- 2001-06-20 BR BR0111813-7A patent/BR0111813A/pt not_active Application Discontinuation
- 2001-06-20 IL IL15317701A patent/IL153177A0/xx not_active IP Right Cessation
- 2001-06-20 NZ NZ523000A patent/NZ523000A/en unknown
- 2001-06-20 CA CA002411172A patent/CA2411172C/en not_active Expired - Fee Related
- 2001-06-20 CN CNB018116396A patent/CN1241573C/zh not_active Expired - Fee Related
- 2001-06-20 AU AU2001278463A patent/AU2001278463B2/en not_active Ceased
- 2001-06-20 HU HU0301257A patent/HUP0301257A2/hu unknown
- 2001-06-20 DK DK01956495T patent/DK1292290T3/da active
- 2001-06-20 US US10/297,915 patent/US20030162722A1/en not_active Abandoned
- 2001-06-20 MX MXPA02012163A patent/MXPA02012163A/es active IP Right Grant
-
2002
- 2002-12-04 ZA ZA200209834A patent/ZA200209834B/en unknown
- 2002-12-18 NO NO20026078A patent/NO329783B1/no not_active IP Right Cessation
-
2003
- 2003-09-22 HK HK03106770.0A patent/HK1054334B/zh not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100438913C (zh) * | 2004-11-22 | 2008-12-03 | 山东蓝金生物工程有限公司 | 一种抗癌药物组合物 |
CN109718228A (zh) * | 2017-10-30 | 2019-05-07 | 沈阳药科大学 | 米托蒽醌的抗肿瘤淋巴转移作用及其药物制剂 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: NERVIANO MEDICAL SCIENCES S R Free format text: FORMER OWNER: PHARMACIA ITALIA S.P.A. Effective date: 20061215 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20061215 Address after: Milan Italy Patentee after: Nerviano Medical Sciences SRL Address before: Milan Italy Patentee before: Pharmacia & Up John S. P. A. |
|
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060215 Termination date: 20110620 |