KR100851648B1 - 남성의 테스토스테론 결핍치료용 물질 - Google Patents

남성의 테스토스테론 결핍치료용 물질 Download PDF

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Publication number
KR100851648B1
KR100851648B1 KR1020047000258A KR20047000258A KR100851648B1 KR 100851648 B1 KR100851648 B1 KR 100851648B1 KR 1020047000258 A KR1020047000258 A KR 1020047000258A KR 20047000258 A KR20047000258 A KR 20047000258A KR 100851648 B1 KR100851648 B1 KR 100851648B1
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South Korea
Prior art keywords
clomiphene
testosterone
trans
treatment
levels
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Expired - Fee Related
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KR1020047000258A
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English (en)
Korean (ko)
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KR20040013131A (ko
Inventor
포돌스키조셉에스.
Original Assignee
레프로스 쎄라피우틱스 아이엔씨.
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Application filed by 레프로스 쎄라피우틱스 아이엔씨. filed Critical 레프로스 쎄라피우틱스 아이엔씨.
Publication of KR20040013131A publication Critical patent/KR20040013131A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020047000258A 2001-07-09 2002-07-09 남성의 테스토스테론 결핍치료용 물질 Expired - Fee Related KR100851648B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30431301P 2001-07-09 2001-07-09
US60/304,313 2001-07-09
PCT/US2002/021524 WO2003005954A2 (en) 2001-07-09 2002-07-09 Methods and materials for the treatment of testosterone deficiency in men

Publications (2)

Publication Number Publication Date
KR20040013131A KR20040013131A (ko) 2004-02-11
KR100851648B1 true KR100851648B1 (ko) 2008-08-13

Family

ID=23175972

Family Applications (1)

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KR1020047000258A Expired - Fee Related KR100851648B1 (ko) 2001-07-09 2002-07-09 남성의 테스토스테론 결핍치료용 물질

Country Status (23)

Country Link
US (6) US7759360B2 (https=)
EP (1) EP1411916B1 (https=)
JP (2) JP4845165B2 (https=)
KR (1) KR100851648B1 (https=)
CN (2) CN1289075C (https=)
AT (1) ATE406153T1 (https=)
AU (1) AU2002318225B2 (https=)
BR (1) BR0211067A (https=)
CA (2) CA2453337C (https=)
CL (1) CL2004000026A1 (https=)
CO (1) CO5550428A2 (https=)
CY (1) CY1108563T1 (https=)
DE (1) DE60228583D1 (https=)
DK (1) DK1411916T3 (https=)
EC (1) ECSP044937A (https=)
ES (1) ES2312593T3 (https=)
MX (1) MXPA04000097A (https=)
NZ (2) NZ530491A (https=)
PL (1) PL211339B1 (https=)
PT (1) PT1411916E (https=)
RU (1) RU2297218C2 (https=)
WO (1) WO2003005954A2 (https=)
ZA (1) ZA200400142B (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7173064B2 (en) 2001-07-09 2007-02-06 Repros Therapeutics Inc. Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy
AU2002318225B2 (en) 2001-07-09 2007-12-13 Repros Therapeutics Inc. Methods and materials for the treatment of testosterone deficiency in men
US7737185B2 (en) * 2001-07-09 2010-06-15 Repros Therapeutics Inc. Methods and compositions with trans-clomiphene
US20080242726A1 (en) * 2004-07-14 2008-10-02 Podolski Joseph S Trans-Clomiphene for the Treatment of Benign Prostate Hypertrophy, Porstate Cancer, Hypogonadism Elevated Triglycerides and High Cholesterol
NZ556499A (en) * 2005-02-04 2011-02-25 Repros Therapeutics Inc Methods and materials with trans-clomiphene for the treatment of male infertility
BRPI0609389A2 (pt) * 2005-03-22 2010-03-30 Repros Therapeutics Inc tablete, composição e respectivos usos
WO2008157335A2 (en) * 2007-06-13 2008-12-24 Quatrx Pharmaceuticals Company Methods for the treatment of erectile dysfunction using fispemifene
US20110118355A1 (en) * 2007-09-21 2011-05-19 Harry Fisch Treatment of migraine headaches using antiestrogens
BRPI0818637A2 (pt) * 2007-10-16 2015-04-07 Repros Therapeutics Inc Métodos de tratamento de sintoma da síndrome metabólica, de glicose em jejum prejudicada, da síndrome metabólica e de redução de níveis de glicose em, jejum em sujeito com hipogonadismo hipogonadotrófico secundário ou idiopático
WO2009052377A1 (en) * 2007-10-18 2009-04-23 Harry Fisch Treatment of migraine headaches using antiestrogens
US20090215733A1 (en) * 2008-02-26 2009-08-27 Michael Charles Scally Therapy for the prophylaxis or treatment of adverse body composition changes and/or decreased muscle strength after androgen or gnrh analogue intake
TWI477276B (zh) 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
RU2474424C2 (ru) * 2010-09-24 2013-02-10 Государственное образовательное учреждение высшего профессионального образования "Ивановская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" Способ коррекции гиперэстрадиолемии и нормогонадотропного гипогонадизма у мужчин
UA113291C2 (xx) 2011-08-04 2017-01-10 Метаболіти транскломіфену і їх застосування
WO2013020215A1 (en) * 2011-08-09 2013-02-14 Adams Kenneth W Use of aromatase inhibitor or estrogen blocker for increasing spermatogenesis or testosterone levels in males
CA2872644A1 (en) 2012-05-31 2013-12-05 Allergan Pharmaceuticals International Limited Formulations and methods for vaginal delivery of antiprogestins
KR20150041793A (ko) * 2012-08-21 2015-04-17 레프로스 쎄라피우틱스 아이엔씨. 트랜스-클로미펜 제형 및 그의 용도
US9545411B2 (en) 2012-11-02 2017-01-17 Repros Therapeutics Inc. Methods and compositions for treating progesterone-dependent conditions
HK1216502A1 (zh) 2012-11-02 2016-11-18 Repros Therapeutics Inc. 用於癌症治療的反式-克羅米芬
US9814687B2 (en) * 2014-08-20 2017-11-14 Professional Compounding Centers Of America Transdermal pharmaceutical compositions including C-SERMs for low testosterone levels in men
RU2586305C1 (ru) * 2015-02-02 2016-06-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Ивановская государственная медицинская академия" Министерства здравоохранения Российской Федерации Способ лечения обструктивной азооспермии и криптозооспермии у пациентов с хроническим простатитом
EP3368506B1 (en) 2016-04-22 2023-09-06 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of enclomiphene citrate having needle shaped crystal habit.

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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0430388A2 (en) * 1989-11-20 1991-06-05 Applied Research Systems ARS Holding N.V. Use of clomiphene for treatment of infertility

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CA2777199A1 (en) 2003-01-23
CA2453337A1 (en) 2003-01-23
US20100286281A1 (en) 2010-11-11
CN1551765A (zh) 2004-12-01
RU2004100535A (ru) 2005-06-10
ZA200400142B (en) 2006-02-22
AU2002318225B2 (en) 2007-12-13
US20150265553A1 (en) 2015-09-24
ES2312593T3 (es) 2009-03-01
EP1411916A2 (en) 2004-04-28
EP1411916B1 (en) 2008-08-27
ECSP044937A (es) 2004-04-28
CO5550428A2 (es) 2005-08-31
DE60228583D1 (de) 2008-10-09
CA2453337C (en) 2012-08-28
KR20040013131A (ko) 2004-02-11
PL211339B1 (pl) 2012-05-31
JP2009280623A (ja) 2009-12-03
US20040241224A1 (en) 2004-12-02
JP4845165B2 (ja) 2011-12-28
NZ551013A (en) 2008-04-30
CN1289075C (zh) 2006-12-13
PL374121A1 (en) 2005-10-03
RU2297218C2 (ru) 2007-04-20
US20140093560A1 (en) 2014-04-03
NZ530491A (en) 2007-08-31
HK1071521A1 (en) 2005-07-22
CN1954807A (zh) 2007-05-02
WO2003005954B1 (en) 2003-12-04
JP2005520779A (ja) 2005-07-14
WO2003005954A2 (en) 2003-01-23
BR0211067A (pt) 2006-10-31
MXPA04000097A (es) 2004-05-21
US8618176B2 (en) 2013-12-31
US7759360B2 (en) 2010-07-20
EP1411916A4 (en) 2005-08-17
US20040097597A1 (en) 2004-05-20
US7368480B2 (en) 2008-05-06
PT1411916E (pt) 2008-12-10
ATE406153T1 (de) 2008-09-15
DK1411916T3 (da) 2008-12-15
CL2004000026A1 (es) 2005-02-04
WO2003005954A3 (en) 2003-10-23
US20160354325A1 (en) 2016-12-08
CY1108563T1 (el) 2014-04-09
US10561624B2 (en) 2020-02-18

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