KR100796079B1 - Ａ82846 글리코펩티드 동족체의 선택적 ｎ-아실화 - Google Patents
Ａ82846 글리코펩티드 동족체의 선택적 ｎ-아실화 Download PDFInfo
- Publication number
- KR100796079B1 KR100796079B1 KR1020027010374A KR20027010374A KR100796079B1 KR 100796079 B1 KR100796079 B1 KR 100796079B1 KR 1020027010374 A KR1020027010374 A KR 1020027010374A KR 20027010374 A KR20027010374 A KR 20027010374A KR 100796079 B1 KR100796079 B1 KR 100796079B1
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- group
- alkyl
- glycopeptide
- monoacylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(C)CC(C(NC([C@@](c(cc1*)ccc1[U]c(cc([C@](C(N[C@@](C*[C@@](C1[C@@](CC2(C)*)OC(C)[C@@]2O)C(NC(C(O)=O)c2cc(O)cc(O)c2-2)=O)c(cc3)cc-2c3O)=O)NC(C(CC(N)=O)N2)=O)cc3Oc4c(*)cc1cc4)c3OC([C@@]([C@]1O)O[C@@](CC3(C)*)OC(C)[C@@]3O)OC(CO)[C@]1O)O)C2=O)=O)NC Chemical compound CC(C)CC(C(NC([C@@](c(cc1*)ccc1[U]c(cc([C@](C(N[C@@](C*[C@@](C1[C@@](CC2(C)*)OC(C)[C@@]2O)C(NC(C(O)=O)c2cc(O)cc(O)c2-2)=O)c(cc3)cc-2c3O)=O)NC(C(CC(N)=O)N2)=O)cc3Oc4c(*)cc1cc4)c3OC([C@@]([C@]1O)O[C@@](CC3(C)*)OC(C)[C@@]3O)OC(CO)[C@]1O)O)C2=O)=O)NC 0.000 description 2
- VNIFXKKKAFQSDY-FWPZAIACSA-N CC([C@@H](C(C)(C)C1)O)O[C@H]1O Chemical compound CC([C@@H](C(C)(C)C1)O)O[C@H]1O VNIFXKKKAFQSDY-FWPZAIACSA-N 0.000 description 1
- YWASOQJYGRLRTN-ACZMJKKPSA-N C[C@@H]([C@@H]1O)OCC[C@]1(C)N Chemical compound C[C@@H]([C@@H]1O)OCC[C@]1(C)N YWASOQJYGRLRTN-ACZMJKKPSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18168300P | 2000-02-11 | 2000-02-11 | |
| US60/181,683 | 2000-02-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20020073546A KR20020073546A (ko) | 2002-09-26 |
| KR100796079B1 true KR100796079B1 (ko) | 2008-01-21 |
Family
ID=22665319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020027010374A Expired - Fee Related KR100796079B1 (ko) | 2000-02-11 | 2001-02-12 | Ａ82846 글리코펩티드 동족체의 선택적 ｎ-아실화 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7365053B2 (enExample) |
| EP (1) | EP1254164B1 (enExample) |
| JP (1) | JP2003522197A (enExample) |
| KR (1) | KR100796079B1 (enExample) |
| CN (1) | CN1422279A (enExample) |
| AT (1) | ATE308560T1 (enExample) |
| AU (2) | AU3818001A (enExample) |
| BR (1) | BR0108268A (enExample) |
| CA (1) | CA2399640A1 (enExample) |
| CZ (1) | CZ20022722A3 (enExample) |
| DE (1) | DE60114567T2 (enExample) |
| MX (1) | MXPA02007739A (enExample) |
| NO (1) | NO20023761L (enExample) |
| NZ (1) | NZ520482A (enExample) |
| PL (1) | PL356966A1 (enExample) |
| WO (1) | WO2001058933A2 (enExample) |
| ZA (1) | ZA200206360B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060091049A (ko) * | 2002-08-30 | 2006-08-17 | 케이.유.루벤 리서치 앤드 디벨럽먼트 | 글리코펩티드 항생제 및 그것의 반합성 유도체 및 항바이러스제로서의 그것의 사용 |
| US8088387B2 (en) * | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| CN1557479A (zh) * | 2004-01-16 | 2004-12-29 | 深圳市海王英特龙生物技术股份有限公 | 干扰素脂质体乳膏 |
| US7632918B2 (en) | 2005-02-28 | 2009-12-15 | Novartis Vaccines And Diagnostics, Inc. | Semi-synthetic glycopeptides with antibiotic activity |
| US20200368312A1 (en) | 2017-05-22 | 2020-11-26 | Insmed Incorporated | Glycopeptide derivative compounds and uses thereof |
| CN108484719A (zh) * | 2018-01-19 | 2018-09-04 | 四川大学 | 硫酸酯化十二指肠糖肽制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4698327A (en) | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
| US4643987A (en) | 1985-08-14 | 1987-02-17 | Eli Lilly And Company | Modified glycopeptides |
| US4639433A (en) | 1985-08-14 | 1987-01-27 | Eli Lilly And Company | Glycopeptide derivatives |
| NZ236393A (en) * | 1989-12-13 | 1992-05-26 | Lilly Co Eli | N-alkylated glycopeptide derivatives prepared from antibiotics a82846 series and pa-42867-a; pharmaceutical compositions |
| US5840684A (en) | 1994-01-28 | 1998-11-24 | Eli Lilly And Company | Glycopeptide antibiotic derivatives |
| EP1073447B1 (en) | 1998-05-01 | 2007-05-09 | Eli Lilly And Company | N1-modified glycopeptides |
-
2001
- 2001-02-12 WO PCT/US2001/004540 patent/WO2001058933A2/en not_active Ceased
- 2001-02-12 EP EP01910588A patent/EP1254164B1/en not_active Expired - Lifetime
- 2001-02-12 CZ CZ20022722A patent/CZ20022722A3/cs unknown
- 2001-02-12 KR KR1020027010374A patent/KR100796079B1/ko not_active Expired - Fee Related
- 2001-02-12 MX MXPA02007739A patent/MXPA02007739A/es active IP Right Grant
- 2001-02-12 AU AU3818001A patent/AU3818001A/xx active Pending
- 2001-02-12 AU AU2001238180A patent/AU2001238180B8/en not_active Ceased
- 2001-02-12 BR BR0108268-0A patent/BR0108268A/pt not_active IP Right Cessation
- 2001-02-12 CN CN01807738A patent/CN1422279A/zh active Pending
- 2001-02-12 AT AT01910588T patent/ATE308560T1/de not_active IP Right Cessation
- 2001-02-12 CA CA002399640A patent/CA2399640A1/en not_active Abandoned
- 2001-02-12 PL PL01356966A patent/PL356966A1/xx not_active Application Discontinuation
- 2001-02-12 NZ NZ520482A patent/NZ520482A/xx unknown
- 2001-02-12 US US10/203,533 patent/US7365053B2/en not_active Expired - Fee Related
- 2001-02-12 DE DE60114567T patent/DE60114567T2/de not_active Expired - Lifetime
- 2001-02-12 JP JP2001558080A patent/JP2003522197A/ja active Pending
-
2002
- 2002-08-08 NO NO20023761A patent/NO20023761L/no unknown
- 2002-08-08 ZA ZA200206360A patent/ZA200206360B/en unknown
Non-Patent Citations (1)
| Title |
|---|
| 유럽특허공보 제0435503 A1 (1991.07.03. 공고) |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200206360B (en) | 2003-11-10 |
| NO20023761D0 (no) | 2002-08-08 |
| CA2399640A1 (en) | 2001-08-16 |
| JP2003522197A (ja) | 2003-07-22 |
| AU2001238180B8 (en) | 2006-07-27 |
| US20070219123A1 (en) | 2007-09-20 |
| WO2001058933A3 (en) | 2002-02-14 |
| DE60114567T2 (de) | 2006-07-27 |
| BR0108268A (pt) | 2003-03-05 |
| EP1254164B1 (en) | 2005-11-02 |
| KR20020073546A (ko) | 2002-09-26 |
| AU2001238180B2 (en) | 2005-12-15 |
| ATE308560T1 (de) | 2005-11-15 |
| WO2001058933A2 (en) | 2001-08-16 |
| DE60114567D1 (de) | 2005-12-08 |
| EP1254164A2 (en) | 2002-11-06 |
| AU3818001A (en) | 2001-08-20 |
| MXPA02007739A (es) | 2002-10-11 |
| CN1422279A (zh) | 2003-06-04 |
| PL356966A1 (en) | 2004-07-12 |
| HK1049171A1 (en) | 2003-05-02 |
| US7365053B2 (en) | 2008-04-29 |
| CZ20022722A3 (cs) | 2003-01-15 |
| NO20023761L (no) | 2002-08-26 |
| NZ520482A (en) | 2004-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
|
| A201 | Request for examination | ||
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| G170 | Re-publication after modification of scope of protection [patent] | ||
| PG1701 | Publication of correction |
St.27 status event code: A-5-5-P10-P19-oth-PG1701 Patent document republication publication date: 20080411 Republication note text: Request for Correction Notice (Document Request) Gazette number: 1007960790000 Gazette reference publication date: 20080121 |
|
| LAPS | Lapse due to unpaid annual fee | ||
| PC1903 | Unpaid annual fee |
St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 20110112 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20110112 |