KR100769865B1 - 선택적 에스트로겐 활성을 가진 16,17-탄소환 축합스테로이드 화합물 - Google Patents

선택적 에스트로겐 활성을 가진 16,17-탄소환 축합스테로이드 화합물 Download PDF

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Publication number
KR100769865B1
KR100769865B1 KR1020027016657A KR20027016657A KR100769865B1 KR 100769865 B1 KR100769865 B1 KR 100769865B1 KR 1020027016657 A KR1020027016657 A KR 1020027016657A KR 20027016657 A KR20027016657 A KR 20027016657A KR 100769865 B1 KR100769865 B1 KR 100769865B1
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KR
South Korea
Prior art keywords
group
compound
alkyl
estrogen receptor
steroid
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Expired - Fee Related
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KR1020027016657A
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English (en)
Korean (ko)
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KR20030028752A (ko
Inventor
로젠후베르트얀요제프
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엔.브이.오가논
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020027016657A 2000-06-06 2001-05-01 선택적 에스트로겐 활성을 가진 16,17-탄소환 축합스테로이드 화합물 Expired - Fee Related KR100769865B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00201986 2000-06-06
EP00201986.7 2000-06-06
PCT/EP2001/004868 WO2002000682A1 (en) 2000-06-06 2001-05-01 16, 17-carbocyclic condensed steroid compounds having selective estrogenic activity

Publications (2)

Publication Number Publication Date
KR20030028752A KR20030028752A (ko) 2003-04-10
KR100769865B1 true KR100769865B1 (ko) 2007-10-25

Family

ID=8171601

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027016657A Expired - Fee Related KR100769865B1 (ko) 2000-06-06 2001-05-01 선택적 에스트로겐 활성을 가진 16,17-탄소환 축합스테로이드 화합물

Country Status (26)

Country Link
US (3) US7868193B2 (enExample)
EP (1) EP1294739B1 (enExample)
JP (1) JP5095902B2 (enExample)
KR (1) KR100769865B1 (enExample)
CN (1) CN1235908C (enExample)
AR (1) AR028080A1 (enExample)
AT (1) ATE293124T1 (enExample)
AU (2) AU5838601A (enExample)
BR (1) BR0111445A (enExample)
CA (1) CA2410220C (enExample)
CZ (1) CZ20024014A3 (enExample)
DE (1) DE60110069T2 (enExample)
DK (1) DK1294739T3 (enExample)
ES (1) ES2240454T3 (enExample)
HU (1) HUP0301190A3 (enExample)
IL (1) IL152957A0 (enExample)
MX (1) MXPA02012117A (enExample)
NO (1) NO324247B1 (enExample)
PE (1) PE20020214A1 (enExample)
PL (1) PL203732B1 (enExample)
PT (1) PT1294739E (enExample)
RU (1) RU2255090C2 (enExample)
SK (1) SK286852B6 (enExample)
TW (1) TWI225068B (enExample)
WO (1) WO2002000682A1 (enExample)
ZA (1) ZA200209452B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8367648B2 (en) 2009-06-10 2013-02-05 Msd Oss B.V. Substituted 16,17-annellated steroid compounds for use in womens healthcare
TW201109346A (en) * 2009-06-10 2011-03-16 Organon Nv Substituted 16,17-annellated steroid compounds for use in women's healthcare

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3194821A (en) 1963-12-30 1965-07-13 Abbott Lab 17alpha-substituted 17beta-hydroxyestrenes
EP0869132A1 (en) * 1997-02-21 1998-10-07 Akzo Nobel N.V. "Steroid compounds having contraceptive and anti-osteoporosis activity"

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2200423C (en) 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3194821A (en) 1963-12-30 1965-07-13 Abbott Lab 17alpha-substituted 17beta-hydroxyestrenes
EP0869132A1 (en) * 1997-02-21 1998-10-07 Akzo Nobel N.V. "Steroid compounds having contraceptive and anti-osteoporosis activity"

Also Published As

Publication number Publication date
CZ20024014A3 (cs) 2003-04-16
US20100249083A1 (en) 2010-09-30
PE20020214A1 (es) 2002-03-13
JP2004501931A (ja) 2004-01-22
SK17072002A3 (sk) 2003-06-03
SK286852B6 (sk) 2009-06-05
IL152957A0 (en) 2003-06-24
PL359238A1 (en) 2004-08-23
CA2410220A1 (en) 2002-01-03
US20040102426A1 (en) 2004-05-27
AU5838601A (en) 2002-01-08
DE60110069T2 (de) 2005-09-22
CA2410220C (en) 2009-04-28
EP1294739A1 (en) 2003-03-26
ATE293124T1 (de) 2005-04-15
DE60110069D1 (de) 2005-05-19
ES2240454T3 (es) 2005-10-16
BR0111445A (pt) 2003-06-03
ZA200209452B (en) 2004-02-20
NO324247B1 (no) 2007-09-17
US20110224183A1 (en) 2011-09-15
CN1235908C (zh) 2006-01-11
JP5095902B2 (ja) 2012-12-12
DK1294739T3 (da) 2005-08-01
NO20025793D0 (no) 2002-12-02
NO20025793L (no) 2002-12-02
MXPA02012117A (es) 2003-06-06
US7868193B2 (en) 2011-01-11
HK1052012A1 (en) 2003-08-29
WO2002000682A1 (en) 2002-01-03
PT1294739E (pt) 2005-06-30
RU2255090C2 (ru) 2005-06-27
KR20030028752A (ko) 2003-04-10
PL203732B1 (pl) 2009-11-30
CN1433426A (zh) 2003-07-30
EP1294739B1 (en) 2005-04-13
HUP0301190A3 (en) 2010-03-29
AU2001258386B2 (en) 2005-08-18
AR028080A1 (es) 2003-04-23
HUP0301190A2 (hu) 2003-08-28
TWI225068B (en) 2004-12-11

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