DE60110069T2 - 16,17-carbocyclisch kondensierte steroid-verbindungen mit selektiver östrogenischer wirksamkeit - Google Patents

16,17-carbocyclisch kondensierte steroid-verbindungen mit selektiver östrogenischer wirksamkeit Download PDF

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Publication number
DE60110069T2
DE60110069T2 DE60110069T DE60110069T DE60110069T2 DE 60110069 T2 DE60110069 T2 DE 60110069T2 DE 60110069 T DE60110069 T DE 60110069T DE 60110069 T DE60110069 T DE 60110069T DE 60110069 T2 DE60110069 T2 DE 60110069T2
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DE
Germany
Prior art keywords
compound according
steroid
estrogen
alkyl
milliliters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60110069T
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German (de)
English (en)
Other versions
DE60110069D1 (de
Inventor
Jan Hubert LOOZEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of DE60110069D1 publication Critical patent/DE60110069D1/de
Publication of DE60110069T2 publication Critical patent/DE60110069T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60110069T 2000-06-06 2001-05-01 16,17-carbocyclisch kondensierte steroid-verbindungen mit selektiver östrogenischer wirksamkeit Expired - Lifetime DE60110069T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00201986 2000-06-06
EP00201986 2000-06-06
PCT/EP2001/004868 WO2002000682A1 (en) 2000-06-06 2001-05-01 16, 17-carbocyclic condensed steroid compounds having selective estrogenic activity

Publications (2)

Publication Number Publication Date
DE60110069D1 DE60110069D1 (de) 2005-05-19
DE60110069T2 true DE60110069T2 (de) 2005-09-22

Family

ID=8171601

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60110069T Expired - Lifetime DE60110069T2 (de) 2000-06-06 2001-05-01 16,17-carbocyclisch kondensierte steroid-verbindungen mit selektiver östrogenischer wirksamkeit

Country Status (26)

Country Link
US (3) US7868193B2 (enExample)
EP (1) EP1294739B1 (enExample)
JP (1) JP5095902B2 (enExample)
KR (1) KR100769865B1 (enExample)
CN (1) CN1235908C (enExample)
AR (1) AR028080A1 (enExample)
AT (1) ATE293124T1 (enExample)
AU (2) AU5838601A (enExample)
BR (1) BR0111445A (enExample)
CA (1) CA2410220C (enExample)
CZ (1) CZ20024014A3 (enExample)
DE (1) DE60110069T2 (enExample)
DK (1) DK1294739T3 (enExample)
ES (1) ES2240454T3 (enExample)
HU (1) HUP0301190A3 (enExample)
IL (1) IL152957A0 (enExample)
MX (1) MXPA02012117A (enExample)
NO (1) NO324247B1 (enExample)
PE (1) PE20020214A1 (enExample)
PL (1) PL203732B1 (enExample)
PT (1) PT1294739E (enExample)
RU (1) RU2255090C2 (enExample)
SK (1) SK286852B6 (enExample)
TW (1) TWI225068B (enExample)
WO (1) WO2002000682A1 (enExample)
ZA (1) ZA200209452B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8367648B2 (en) 2009-06-10 2013-02-05 Msd Oss B.V. Substituted 16,17-annellated steroid compounds for use in womens healthcare
TW201109346A (en) * 2009-06-10 2011-03-16 Organon Nv Substituted 16,17-annellated steroid compounds for use in women's healthcare

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3194821A (en) * 1963-12-30 1965-07-13 Abbott Lab 17alpha-substituted 17beta-hydroxyestrenes
CA2200423C (en) 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
IL123195A (en) * 1997-02-21 2002-11-10 Akzo Nobel Nv Steroid compounds with anti-pregnancy activity and against bone thinning, preparation and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
CZ20024014A3 (cs) 2003-04-16
US20100249083A1 (en) 2010-09-30
PE20020214A1 (es) 2002-03-13
JP2004501931A (ja) 2004-01-22
SK17072002A3 (sk) 2003-06-03
SK286852B6 (sk) 2009-06-05
IL152957A0 (en) 2003-06-24
PL359238A1 (en) 2004-08-23
CA2410220A1 (en) 2002-01-03
US20040102426A1 (en) 2004-05-27
AU5838601A (en) 2002-01-08
CA2410220C (en) 2009-04-28
KR100769865B1 (ko) 2007-10-25
EP1294739A1 (en) 2003-03-26
ATE293124T1 (de) 2005-04-15
DE60110069D1 (de) 2005-05-19
ES2240454T3 (es) 2005-10-16
BR0111445A (pt) 2003-06-03
ZA200209452B (en) 2004-02-20
NO324247B1 (no) 2007-09-17
US20110224183A1 (en) 2011-09-15
CN1235908C (zh) 2006-01-11
JP5095902B2 (ja) 2012-12-12
DK1294739T3 (da) 2005-08-01
NO20025793D0 (no) 2002-12-02
NO20025793L (no) 2002-12-02
MXPA02012117A (es) 2003-06-06
US7868193B2 (en) 2011-01-11
HK1052012A1 (en) 2003-08-29
WO2002000682A1 (en) 2002-01-03
PT1294739E (pt) 2005-06-30
RU2255090C2 (ru) 2005-06-27
KR20030028752A (ko) 2003-04-10
PL203732B1 (pl) 2009-11-30
CN1433426A (zh) 2003-07-30
EP1294739B1 (en) 2005-04-13
HUP0301190A3 (en) 2010-03-29
AU2001258386B2 (en) 2005-08-18
AR028080A1 (es) 2003-04-23
HUP0301190A2 (hu) 2003-08-28
TWI225068B (en) 2004-12-11

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