KR100750693B1 - 캄프토테신 유사체 및 그의 제조 방법 - Google Patents

캄프토테신 유사체 및 그의 제조 방법

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Publication number
KR100750693B1
KR100750693B1 KR1020017007539A KR20017007539A KR100750693B1 KR 100750693 B1 KR100750693 B1 KR 100750693B1 KR 1020017007539 A KR1020017007539 A KR 1020017007539A KR 20017007539 A KR20017007539 A KR 20017007539A KR 100750693 B1 KR100750693 B1 KR 100750693B1
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KR
South Korea
Prior art keywords
group
compound
amino
alkyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020017007539A
Other languages
English (en)
Korean (ko)
Other versions
KR20010101250A (ko
Inventor
커런데니스피.
조시엔휴버트
붐데이빗
버크토마스지.
Original Assignee
유니버시티 오브 피츠버그
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 유니버시티 오브 피츠버그 filed Critical 유니버시티 오브 피츠버그
Publication of KR20010101250A publication Critical patent/KR20010101250A/ko
Application granted granted Critical
Publication of KR100750693B1 publication Critical patent/KR100750693B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
    • C07F7/083—Syntheses without formation of a Si-C bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020017007539A 1998-12-15 1999-12-15 캄프토테신 유사체 및 그의 제조 방법 Expired - Fee Related KR100750693B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/212,178 US6136978A (en) 1993-06-30 1998-12-15 Camptothecin analogs and methods of preparation thereof
US09/212,178 1998-12-15

Publications (2)

Publication Number Publication Date
KR20010101250A KR20010101250A (ko) 2001-11-14
KR100750693B1 true KR100750693B1 (ko) 2007-08-22

Family

ID=22789889

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017007539A Expired - Fee Related KR100750693B1 (ko) 1998-12-15 1999-12-15 캄프토테신 유사체 및 그의 제조 방법

Country Status (10)

Country Link
US (1) US6136978A (https=)
EP (1) EP1140948A4 (https=)
JP (1) JP4638987B2 (https=)
KR (1) KR100750693B1 (https=)
CN (1) CN1177850C (https=)
AU (1) AU777786B2 (https=)
CA (1) CA2353822C (https=)
HK (1) HK1044156B (https=)
NZ (1) NZ512210A (https=)
WO (1) WO2000035924A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150343A (en) * 1993-06-30 2000-11-21 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6497896B2 (en) 2001-02-12 2002-12-24 Supergen, Inc. Method for administering camptothecins via injection of a pharmaceutical composition comprising microdroplets containing a camptothecin
US6509027B2 (en) 2001-02-12 2003-01-21 Supergen, Inc. Injectable pharmaceutical composition comprising coated particles of camptothecin
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
US7183415B2 (en) * 2001-10-25 2007-02-27 Takeda Pharmaceutical Company Limited Quinoline compound
US7064202B1 (en) 2003-05-12 2006-06-20 University Of Kentucky Research Foundation Camptothecin intermediates and prodrugs and methods of preparation thereof
US7064206B1 (en) 2003-05-12 2006-06-20 University Of Kentucky Research Foundation Highly lipophilic camptothecin intermediates and prodrugs and methods of preparation thereof
ZA200604758B (en) * 2003-12-17 2007-10-31 Bionumerik Pharmaceuticals Inc Process for making camptothecin derivatives
US7654501B2 (en) * 2007-06-06 2010-02-02 Matthews Stewart D Vehicle parking assistance device and method for use of same
EP2197879B1 (en) * 2007-10-16 2014-01-22 Bionumerik Pharmaceuticals, Inc. C7-substituted camptothecin analogs
EP2197279B1 (en) * 2007-10-16 2017-01-18 Bionumerik Pharmaceuticals, Inc. C10-substituted camptothecin analogs
US7687497B2 (en) * 2007-10-16 2010-03-30 Bionumerik Pharmaceuticals, Inc. C10-substituted camptothecin analogs
US8569265B2 (en) * 2011-05-06 2013-10-29 Bionumerik Pharmaceuticals, Inc. Deuterated analogs of (4S)-4-ethyl-4-hydroxy-11-[2- (trimethylsilyl)ethyl]-1H-pyrano[3′, 4′:6,7] indolizino [1,2-b]quinoline-3,14(4H, 12H)-dione and methods of use thereof
US8722886B1 (en) * 2012-11-13 2014-05-13 Bionumerik Pharmaceuticals, Inc. Methods for the total chemical synthesis of enantiomerically-pure 7-(2′-trimethylsilyl)ethyl camptothecin
WO2016064900A1 (en) * 2014-10-22 2016-04-28 Arno Therapeutics, Inc. Methods and systems for camptothecin analog synthesis
CN107964257B (zh) * 2016-10-20 2021-07-09 香港理工大学深圳研究院 喹啉鎓离子骨架结构有机染料化合物及其制备方法和应用
IL308734A (en) * 2021-05-27 2024-01-01 Zymeworks Bc Inc Camptothecin analogues, conjugates and methods of use
CN118414339A (zh) * 2021-12-16 2024-07-30 迈威(上海)生物科技股份有限公司 一种喜树碱类化合物及其偶联物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035940A1 (en) * 1997-02-14 1998-08-20 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5405963A (en) * 1993-06-10 1995-04-11 Smithkline Beecham Corporation Process for asymmetric total synthesis of camptothecin analogues
US5744605A (en) * 1993-06-30 1998-04-28 University Of Pittsburgh Intermediates in the synthesis of (+) camptothecin and related compounds and synthesis thereof
US6150343A (en) * 1993-06-30 2000-11-21 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
JPH09123996A (ja) * 1995-10-30 1997-05-13 Sanshin Ind Co Ltd 船外機のシフト駆動機構
IL127800A (en) * 1996-08-19 2005-11-20 Bionumerik Pharmaceuticals Inc Highly lipophilic 7-substituted camptothecin derivatives and pharmaceutical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035940A1 (en) * 1997-02-14 1998-08-20 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Bioorganic & Medicinal Chemistry, Vol.7, No.24, pp3189-3194(1997) *
Bioorganic & Medicinal Chemistry, Vol.7, No.24, pp3189-3194(1997). *
WO 98/35940 A(1998.08.20.).

Also Published As

Publication number Publication date
CA2353822A1 (en) 2000-06-22
AU777786B2 (en) 2004-10-28
CA2353822C (en) 2011-05-31
AU3123600A (en) 2000-07-03
HK1044156B (zh) 2005-04-08
EP1140948A4 (en) 2008-01-02
NZ512210A (en) 2004-12-24
JP2002532505A (ja) 2002-10-02
WO2000035924A1 (en) 2000-06-22
JP4638987B2 (ja) 2011-02-23
CN1177850C (zh) 2004-12-01
HK1044156A1 (en) 2002-10-11
US6136978A (en) 2000-10-24
CN1352646A (zh) 2002-06-05
KR20010101250A (ko) 2001-11-14
EP1140948A1 (en) 2001-10-10

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US7514418B2 (en) Camptothecin analogs and methods of preparation thereof
US6743917B2 (en) Camptothecin analogs and methods of preparation thereof

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