HK1044156B - 喜樹碱類似物及其製備方法 - Google Patents

喜樹碱類似物及其製備方法 Download PDF

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Publication number
HK1044156B
HK1044156B HK02105702.6A HK02105702A HK1044156B HK 1044156 B HK1044156 B HK 1044156B HK 02105702 A HK02105702 A HK 02105702A HK 1044156 B HK1044156 B HK 1044156B
Authority
HK
Hong Kong
Prior art keywords
group
compound
alkyl
amino
hydroxy
Prior art date
Application number
HK02105702.6A
Other languages
English (en)
Chinese (zh)
Other versions
HK1044156A1 (en
Inventor
D‧P‧柯伦
D‧P‧柯倫
H‧乔森
D‧博
H‧喬森
T‧G‧伯克
Original Assignee
匹兹堡大学
匹兹堡大學
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 匹兹堡大学, 匹兹堡大學 filed Critical 匹兹堡大学
Publication of HK1044156A1 publication Critical patent/HK1044156A1/xx
Publication of HK1044156B publication Critical patent/HK1044156B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
    • C07F7/083—Syntheses without formation of a Si-C bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK02105702.6A 1998-12-15 1999-12-15 喜樹碱類似物及其製備方法 HK1044156B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/212,178 US6136978A (en) 1993-06-30 1998-12-15 Camptothecin analogs and methods of preparation thereof
US09/212,178 1998-12-15
PCT/US1999/029937 WO2000035924A1 (en) 1998-12-15 1999-12-15 Camptothecin analogs and methods of preparation thereof

Publications (2)

Publication Number Publication Date
HK1044156A1 HK1044156A1 (en) 2002-10-11
HK1044156B true HK1044156B (zh) 2005-04-08

Family

ID=22789889

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02105702.6A HK1044156B (zh) 1998-12-15 1999-12-15 喜樹碱類似物及其製備方法

Country Status (10)

Country Link
US (1) US6136978A (https=)
EP (1) EP1140948A4 (https=)
JP (1) JP4638987B2 (https=)
KR (1) KR100750693B1 (https=)
CN (1) CN1177850C (https=)
AU (1) AU777786B2 (https=)
CA (1) CA2353822C (https=)
HK (1) HK1044156B (https=)
NZ (1) NZ512210A (https=)
WO (1) WO2000035924A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150343A (en) * 1993-06-30 2000-11-21 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6497896B2 (en) 2001-02-12 2002-12-24 Supergen, Inc. Method for administering camptothecins via injection of a pharmaceutical composition comprising microdroplets containing a camptothecin
US6509027B2 (en) 2001-02-12 2003-01-21 Supergen, Inc. Injectable pharmaceutical composition comprising coated particles of camptothecin
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
US7183415B2 (en) * 2001-10-25 2007-02-27 Takeda Pharmaceutical Company Limited Quinoline compound
US7064202B1 (en) 2003-05-12 2006-06-20 University Of Kentucky Research Foundation Camptothecin intermediates and prodrugs and methods of preparation thereof
US7064206B1 (en) 2003-05-12 2006-06-20 University Of Kentucky Research Foundation Highly lipophilic camptothecin intermediates and prodrugs and methods of preparation thereof
ZA200604758B (en) * 2003-12-17 2007-10-31 Bionumerik Pharmaceuticals Inc Process for making camptothecin derivatives
US7654501B2 (en) * 2007-06-06 2010-02-02 Matthews Stewart D Vehicle parking assistance device and method for use of same
EP2197879B1 (en) * 2007-10-16 2014-01-22 Bionumerik Pharmaceuticals, Inc. C7-substituted camptothecin analogs
EP2197279B1 (en) * 2007-10-16 2017-01-18 Bionumerik Pharmaceuticals, Inc. C10-substituted camptothecin analogs
US7687497B2 (en) * 2007-10-16 2010-03-30 Bionumerik Pharmaceuticals, Inc. C10-substituted camptothecin analogs
US8569265B2 (en) * 2011-05-06 2013-10-29 Bionumerik Pharmaceuticals, Inc. Deuterated analogs of (4S)-4-ethyl-4-hydroxy-11-[2- (trimethylsilyl)ethyl]-1H-pyrano[3′, 4′:6,7] indolizino [1,2-b]quinoline-3,14(4H, 12H)-dione and methods of use thereof
US8722886B1 (en) * 2012-11-13 2014-05-13 Bionumerik Pharmaceuticals, Inc. Methods for the total chemical synthesis of enantiomerically-pure 7-(2′-trimethylsilyl)ethyl camptothecin
WO2016064900A1 (en) * 2014-10-22 2016-04-28 Arno Therapeutics, Inc. Methods and systems for camptothecin analog synthesis
CN107964257B (zh) * 2016-10-20 2021-07-09 香港理工大学深圳研究院 喹啉鎓离子骨架结构有机染料化合物及其制备方法和应用
IL308734A (en) * 2021-05-27 2024-01-01 Zymeworks Bc Inc Camptothecin analogues, conjugates and methods of use
CN118414339A (zh) * 2021-12-16 2024-07-30 迈威(上海)生物科技股份有限公司 一种喜树碱类化合物及其偶联物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5405963A (en) * 1993-06-10 1995-04-11 Smithkline Beecham Corporation Process for asymmetric total synthesis of camptothecin analogues
US5744605A (en) * 1993-06-30 1998-04-28 University Of Pittsburgh Intermediates in the synthesis of (+) camptothecin and related compounds and synthesis thereof
US6150343A (en) * 1993-06-30 2000-11-21 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
JPH09123996A (ja) * 1995-10-30 1997-05-13 Sanshin Ind Co Ltd 船外機のシフト駆動機構
IL127800A (en) * 1996-08-19 2005-11-20 Bionumerik Pharmaceuticals Inc Highly lipophilic 7-substituted camptothecin derivatives and pharmaceutical compositions containing them
ATE329903T1 (de) * 1997-02-14 2006-07-15 Bionumerik Pharmaceuticals Inc Hochgradig lipophile camptothecin-derivate

Also Published As

Publication number Publication date
CA2353822A1 (en) 2000-06-22
AU777786B2 (en) 2004-10-28
CA2353822C (en) 2011-05-31
AU3123600A (en) 2000-07-03
EP1140948A4 (en) 2008-01-02
NZ512210A (en) 2004-12-24
JP2002532505A (ja) 2002-10-02
WO2000035924A1 (en) 2000-06-22
JP4638987B2 (ja) 2011-02-23
CN1177850C (zh) 2004-12-01
HK1044156A1 (en) 2002-10-11
KR100750693B1 (ko) 2007-08-22
US6136978A (en) 2000-10-24
CN1352646A (zh) 2002-06-05
KR20010101250A (ko) 2001-11-14
EP1140948A1 (en) 2001-10-10

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20121215