KR100729883B1 - 죽상경화증 및 비만증을 치료하기 위한 cetp억제제로서의 1,2,4-치환된 1,2,3,4-테트라하이드로- 및1,2-디하이드로-퀴놀린 및1,2,3,4-테트라하이드로-퀴녹살린 유도체 - Google Patents
죽상경화증 및 비만증을 치료하기 위한 cetp억제제로서의 1,2,4-치환된 1,2,3,4-테트라하이드로- 및1,2-디하이드로-퀴놀린 및1,2,3,4-테트라하이드로-퀴녹살린 유도체 Download PDFInfo
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- KR100729883B1 KR100729883B1 KR1020057018383A KR20057018383A KR100729883B1 KR 100729883 B1 KR100729883 B1 KR 100729883B1 KR 1020057018383 A KR1020057018383 A KR 1020057018383A KR 20057018383 A KR20057018383 A KR 20057018383A KR 100729883 B1 KR100729883 B1 KR 100729883B1
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- Prior art keywords
- trifluoromethyl
- methyl
- bis
- quinoline
- phenyl
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US45827403P | 2003-03-28 | 2003-03-28 | |
US60/458,274 | 2003-03-28 |
Publications (2)
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KR20050115938A KR20050115938A (ko) | 2005-12-08 |
KR100729883B1 true KR100729883B1 (ko) | 2007-06-18 |
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KR1020057018383A KR100729883B1 (ko) | 2003-03-28 | 2004-03-15 | 죽상경화증 및 비만증을 치료하기 위한 cetp억제제로서의 1,2,4-치환된 1,2,3,4-테트라하이드로- 및1,2-디하이드로-퀴놀린 및1,2,3,4-테트라하이드로-퀴녹살린 유도체 |
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EP (1) | EP1622872A1 (pt) |
JP (1) | JP2006521344A (pt) |
KR (1) | KR100729883B1 (pt) |
CN (1) | CN1795177A (pt) |
AR (1) | AR044507A1 (pt) |
AU (1) | AU2004224082A1 (pt) |
BR (1) | BRPI0408897A (pt) |
CA (1) | CA2520405A1 (pt) |
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EA (1) | EA200501376A1 (pt) |
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Families Citing this family (32)
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DK1599468T3 (da) | 2003-01-14 | 2008-02-04 | Arena Pharm Inc | 1,2,3-trisubstituerede aryl- og heteroarylderivater som modulatorer af metabolisme og forebyggelse og behandling af forstyrrelser forbundet dermed såsom diabetes og hyperglykæmi |
US6992096B2 (en) | 2003-04-11 | 2006-01-31 | Ptc Therapeutics, Inc. | 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
EP1644375A2 (en) | 2003-07-14 | 2006-04-12 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
WO2006033001A1 (en) * | 2004-09-23 | 2006-03-30 | Pfizer Products Inc. | Quinoline compounds |
US20070149567A1 (en) * | 2004-09-23 | 2007-06-28 | Pfizer Inc | Quinoline compounds |
AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
AU2006216713A1 (en) * | 2005-02-24 | 2006-08-31 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
US7888376B2 (en) * | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
PE20071025A1 (es) * | 2006-01-31 | 2007-10-17 | Mitsubishi Tanabe Pharma Corp | Compuesto amina trisustituido |
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HRP20050859A2 (en) | 2006-02-28 |
WO2004085401A8 (en) | 2005-12-01 |
EA200501376A1 (ru) | 2006-04-28 |
AR044507A1 (es) | 2005-09-14 |
TNSN05243A1 (fr) | 2007-06-11 |
TWI285641B (en) | 2007-08-21 |
PE20050389A1 (es) | 2005-05-30 |
OA13153A (en) | 2006-12-13 |
PA8598901A1 (es) | 2004-11-26 |
UY28243A1 (es) | 2004-11-08 |
NO20054989L (no) | 2005-12-16 |
MXPA05010456A (es) | 2006-03-21 |
NO20054989D0 (no) | 2005-10-26 |
JP2006521344A (ja) | 2006-09-21 |
TW200508222A (en) | 2005-03-01 |
GT200400050A (es) | 2005-03-02 |
MA27828A1 (fr) | 2006-04-03 |
AU2004224082A1 (en) | 2004-10-07 |
CL2004000639A1 (es) | 2005-02-04 |
BRPI0408897A (pt) | 2006-04-18 |
CN1795177A (zh) | 2006-06-28 |
EP1622872A1 (en) | 2006-02-08 |
KR20050115938A (ko) | 2005-12-08 |
CA2520405A1 (en) | 2004-10-07 |
WO2004085401A1 (en) | 2004-10-07 |
ZA200507819B (en) | 2007-04-25 |
ECSP056040A (es) | 2006-01-27 |
NL1025839C2 (nl) | 2006-09-06 |
NL1025839A1 (nl) | 2004-09-30 |
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