KR100710958B1 - 데하이드로 아미노산 - Google Patents

데하이드로 아미노산 Download PDF

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KR100710958B1
KR100710958B1 KR1020027010215A KR20027010215A KR100710958B1 KR 100710958 B1 KR100710958 B1 KR 100710958B1 KR 1020027010215 A KR1020027010215 A KR 1020027010215A KR 20027010215 A KR20027010215 A KR 20027010215A KR 100710958 B1 KR100710958 B1 KR 100710958B1
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amino
hydrogen
formula
compound
acid
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KR1020027010215A
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Korean (ko)
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KR20020073206A (ko
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포토우히네이더
길레스피폴
구드리로버트윌리엄
피에트라니코-콜세리린
윤웨이야
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에프. 호프만-라 로슈 아게
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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07B2200/07—Optical isomers

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MXPA05000020A (es) * 2002-07-01 2005-12-05 Pharmacia & Upjohn Co Llc Inhibidores de polimerasa ns5b de la infeccion del virus de la hepatitis c (hcv).
US6974815B2 (en) 2002-10-11 2005-12-13 Bristol-Myers Squibb Company Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
PL1682537T3 (pl) * 2003-11-05 2012-09-28 Sarcode Bioscience Inc Modulatory adhezji komórkowej
JP2007535553A (ja) * 2004-04-29 2007-12-06 アボット・ラボラトリーズ アミノ−テトラゾール類縁体および使用方法
BRPI0515483A (pt) * 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos para o tratamento de doenças mediadas por enzimas estearoil-coa desaturase
TW200616634A (en) 2004-10-01 2006-06-01 Bristol Myers Squibb Co Crystalline forms and process for preparing spiro-hydantoin compounds
US7186727B2 (en) 2004-12-14 2007-03-06 Bristol-Myers Squibb Company Pyridyl-substituted spiro-hydantoin compounds and use thereof
JP5794721B2 (ja) 2005-05-17 2015-10-14 サーコード バイオサイエンス インコーポレイテッド 眼障害の治療のための組成物および方法
AU2008317473B2 (en) 2007-10-19 2014-07-17 Bausch + Lomb Ireland Limited Compositions and methods for treatment of diabetic retinopathy
WO2009139817A2 (fr) 2008-04-15 2009-11-19 Sarcode Corporation Produit pharmaceutique cristallin et ses procédés de préparation et d'utilisation
CN102056485A (zh) * 2008-04-15 2011-05-11 萨可德公司 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂
WO2009128933A1 (fr) * 2008-04-15 2009-10-22 Sarcode Corporation Antagonistes de lfa-1 sous forme d'aérosol utilisés en traitement localisé de troubles de nature immunitaire
EP2276508A4 (fr) * 2008-04-15 2011-12-28 Sarcode Bioscience Inc Administration d'antagonistes de lfa-1 au système gastro-intestinal
WO2011050175A1 (fr) 2009-10-21 2011-04-28 Sarcode Corporation Agent pharmaceutique cristallin et procédés de préparation et utilisation de celui-ci
US20120270875A1 (en) * 2011-03-16 2012-10-25 Paul Gillespie Pyrimidine amide compounds
US9650363B2 (en) 2012-01-27 2017-05-16 Hoffmann-La Roche Inc. Integrin antagonist conjugates for targeted delivery to cells expressing LFA-1
AU2013295706A1 (en) 2012-07-25 2015-02-19 Sarcode Bioscience Inc. LFA-1 inhibitor and polymorph thereof
CN106631867B (zh) * 2016-12-27 2018-06-22 河南省科学院化学研究所有限公司 一种合成2-苯甲酰氨基-3-芳基丙烯酸酯的方法
CN116334049B (zh) * 2019-11-20 2023-11-17 珠海联邦制药股份有限公司 人工设计的赖氨酰内切酶及编码序列和发酵方法

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EP0410742A1 (fr) * 1989-07-26 1991-01-30 Allergan, Inc. Composés phényléthényliques ayant une activité semblable aux rétinoides
US5457124A (en) 1993-12-07 1995-10-10 Hoffmann-La Roche Inc. Carboxylic acid Leukotriene B4 antagonists

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JP2003522751A (ja) 2003-07-29
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MXPA02007461A (es) 2002-12-13
US20020161237A1 (en) 2002-10-31
WO2001058853A1 (fr) 2001-08-16
US6515124B2 (en) 2003-02-04
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