KR100694919B1 - ｇｐ41 단편의 아세틸화 - Google Patents

ｇｐ41 단편의 아세틸화

Info

Publication number
KR100694919B1
KR100694919B1 KR10-2006-7006344A KR20067006344A KR100694919B1 KR 100694919 B1 KR100694919 B1 KR 100694919B1 KR 20067006344 A KR20067006344 A KR 20067006344A KR 100694919 B1 KR100694919 B1 KR 100694919B1
Authority
KR
South Korea
Prior art keywords
acetylation
fragments
Prior art date
Application number
KR10-2006-7006344A
Other languages
English (en)
Other versions
KR20060035814A (ko
Inventor
에바 훼스
토마스 마이어
가브릴레 페스틀린
프리드리히 폽
클라우스 라이헤르트
라이너 슈무크
베른트 슈나이딩거
크리스토프 자이델
빌헬름 티셔
Original Assignee
에프. 호프만-라 로슈 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프. 호프만-라 로슈 아게 filed Critical 에프. 호프만-라 로슈 아게
Publication of KR20060035814A publication Critical patent/KR20060035814A/ko
Application granted granted Critical
Publication of KR100694919B1 publication Critical patent/KR100694919B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR10-2006-7006344A 2001-06-15 2006-03-31 ｇｐ41 단편의 아세틸화 KR100694919B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01114497.9 2001-06-15
EP01114497 2001-06-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020037016312A Division KR100614714B1 (ko) 2001-06-15 2002-05-27 ｇｐ41 단편의 아세틸화

Publications (2)

Publication Number Publication Date
KR20060035814A KR20060035814A (ko) 2006-04-26
KR100694919B1 true KR100694919B1 (ko) 2007-03-14

Family

ID=8177732

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020037016312A KR100614714B1 (ko) 2001-06-15 2002-05-27 ｇｐ41 단편의 아세틸화
KR10-2006-7006344A KR100694919B1 (ko) 2001-06-15 2006-03-31 ｇｐ41 단편의 아세틸화

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020037016312A KR100614714B1 (ko) 2001-06-15 2002-05-27 ｇｐ41 단편의 아세틸화

Country Status (10)

Country Link
US (2) US6858410B2 (ko)
EP (1) EP1402050B1 (ko)
JP (1) JP4267444B2 (ko)
KR (2) KR100614714B1 (ko)
CN (1) CN1255548C (ko)
AU (1) AU2002314111A1 (ko)
CA (1) CA2450548C (ko)
ES (1) ES2525317T3 (ko)
MX (1) MXPA03011453A (ko)
WO (1) WO2002103026A2 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100614714B1 (ko) 2001-06-15 2006-08-21 에프. 호프만-라 로슈 아게 ｇｐ41 단편의 아세틸화
CA2443365C (en) * 2002-11-19 2010-01-12 F. Hoffmann-La Roche Ag Methods for the recombinant production of antifusogenic peptides
WO2005063282A1 (en) * 2003-12-23 2005-07-14 Centocor, Inc. Anti-retroviral agents, compositions, methods and uses
CN101489571B (zh) * 2005-11-02 2014-06-18 Ambrx公司 生物合成多肽融合抑制剂
GB0608368D0 (en) * 2006-04-28 2006-06-07 Isis Innovation Process for making Oligopeptides
TW200817438A (en) * 2006-08-17 2008-04-16 Hoffmann La Roche A conjugate of an antibody against CCR5 and an antifusogenic peptide
CL2008000707A1 (es) * 2007-03-13 2008-09-22 Hoffmann La Roche Conjugado de polipeptidos antifusogenicos y polipeptidos derivados de la cabeza globular del factor del complemento c1q; composicion farmaceutica que lo comprende; su uso para tratar infecciones viricas; y metodo de produccion.
EP2858661B1 (en) * 2011-12-29 2020-04-22 Dana-Farber Cancer Institute, Inc. Stabilized antiviral fusion helices
WO2014012090A1 (en) * 2012-07-13 2014-01-16 The Broad Institute, Inc. Molecular sleds comprising a positively-charged amino acid sequence and a molecular cargo and uses thereof
EP3423075B1 (en) 2016-02-29 2024-04-03 Dana-Farber Cancer Institute, Inc. Stapled intracellular-targeting antimicrobial peptides to treat infection
JP7305614B2 (ja) 2017-07-19 2023-07-10 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 抗生物質耐性細菌感染症の処置のための安定化抗菌ペプチド

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US123039A (en) * 1872-01-23 Improvement in canal-boats
US9667A (en) * 1853-04-12 Washiug-machine
DE3034045A1 (de) 1980-09-10 1982-04-22 Boehringer Mannheim Gmbh, 6800 Mannheim Endoproteinase-lys-c aus bakterien, verfahren zu ihrer gewinnung und verwendung
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US5453363A (en) 1985-10-23 1995-09-26 Boehringer Mannheim Gmbh Process for the activation of t-PA or Ing after genetic expression in prokaryotes
CU22222A1 (es) * 1989-08-03 1995-01-31 Cigb Procedimiento para la expresion de proteinas heterologicas producidas de forma fusionada en escherichia coli, su uso, vectores de expresion y cepas recombinantes
US5595887A (en) 1990-07-16 1997-01-21 Bionebraska, Inc. Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment
NZ255041A (en) 1992-07-13 1996-11-26 Bionebraska Inc Preparation of a recombinant single copy polypeptide or portion thereof modified with a terminal alpha amino carbon reactive group and reactive side chain groups involving biologically added protective groups
US5656456A (en) 1992-07-13 1997-08-12 Bionebraska, Inc. Chemical method for selective modification of the N- and/or C-terminal amino acid α-carbon reactive group of a recombinant polypeptide or a portion thereof
NZ254640A (en) 1992-07-20 1997-04-24 Univ Duke Hiv protein fragments of transmembrane glycoprotein gp41 (dp-107) with antiviral activity and their use
JPH08501213A (ja) * 1992-08-21 1996-02-13 ザ ユニバーシティー オブ ブリティッシュ コロンビア カチオン性ペプチド及びその製造方法
US5464933A (en) 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
US6479055B1 (en) 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US6017536A (en) 1993-06-07 2000-01-25 Trimeris, Inc. Simian immunodeficiency virus peptides with antifusogenic and antiviral activities
US5512459A (en) 1993-07-20 1996-04-30 Bionebraska, Inc. Enzymatic method for modification or recombinant polypeptides
US5648244A (en) * 1993-09-27 1997-07-15 President And Fellows Of Harvard College Production, purification, cleavage and use of fusion peptides
DE4405810A1 (de) * 1994-02-23 1995-08-24 Behringwerke Ag Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung
JPH11507632A (ja) * 1995-06-07 1999-07-06 トリメリス，インコーポレーテッド 併用療法を用いたｈｉｖおよび他のウイルス感染の治療
US6846905B2 (en) * 1997-08-15 2005-01-25 Abbott Laboratories Antigen constructs useful in the detection and differentiation of antibodies to HIV
ES2245505T3 (es) 1998-03-23 2006-01-01 Trimeris Inc. Metodos y composiciones para la sintesis de peptidos (t-20).
US6258782B1 (en) 1998-05-20 2001-07-10 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
US6656906B1 (en) 1998-05-20 2003-12-02 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
DE69930938T2 (de) * 1998-07-10 2007-01-11 Scios Inc., Fremont Verfahren zur herstellung eines peptids mit einem pi grösser als 8 oder kleiner als 5
AU1255300A (en) 1998-11-20 2000-06-13 Micrologix Biotech, Inc. Efficient methods for producing antimicrobial cationic peptides in host cells
CA2359892A1 (en) * 1999-01-08 2000-07-13 Panacos Pharmaceuticals, Inc. Methods of eliciting broadly neutralizing antibodies targeting hiv-1 gp41
CN1351611A (zh) 1999-05-17 2002-05-29 康久化学公司 病毒感染的长效融合肽抑制剂
ES2296665T3 (es) * 1999-12-16 2008-05-01 Whitehead Institute For Biomedical Research Proteina cinco-helice.
KR100614714B1 (ko) 2001-06-15 2006-08-21 에프. 호프만-라 로슈 아게 ｇｐ41 단편의 아세틸화

Also Published As

Publication number Publication date
US7348423B2 (en) 2008-03-25
CN1516738A (zh) 2004-07-28
CN1255548C (zh) 2006-05-10
US6858410B2 (en) 2005-02-22
WO2002103026A3 (en) 2003-11-20
KR20060035814A (ko) 2006-04-26
EP1402050B1 (en) 2014-10-29
AU2002314111A1 (en) 2003-01-02
JP2004529660A (ja) 2004-09-30
MXPA03011453A (es) 2004-04-05
WO2002103026A2 (en) 2002-12-27
US20050058659A1 (en) 2005-03-17
KR20040010705A (ko) 2004-01-31
US20030104581A1 (en) 2003-06-05
JP4267444B2 (ja) 2009-05-27
CA2450548C (en) 2012-05-01
EP1402050A2 (en) 2004-03-31
ES2525317T3 (es) 2014-12-22
KR100614714B1 (ko) 2006-08-21
CA2450548A1 (en) 2002-12-27

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