KR100692232B1 - 피루베이트 탈수소효소 활성을 증가시키는 치환된 ｎ-페닐2-히드록시-2-메틸-3,3,3-트리플루오로프로판아미드 유도체 - Google Patents

피루베이트 탈수소효소 활성을 증가시키는 치환된 ｎ-페닐2-히드록시-2-메틸-3,3,3-트리플루오로프로판아미드 유도체 Download PDF

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Publication number
KR100692232B1
KR100692232B1 KR1020027002841A KR20027002841A KR100692232B1 KR 100692232 B1 KR100692232 B1 KR 100692232B1 KR 1020027002841 A KR1020027002841 A KR 1020027002841A KR 20027002841 A KR20027002841 A KR 20027002841A KR 100692232 B1 KR100692232 B1 KR 100692232B1
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South Korea
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optionally substituted
hydroxy
methyl
alkyl
formula
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Expired - Fee Related
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KR1020027002841A
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English (en)
Korean (ko)
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KR20020067498A (ko
Inventor
부트린로저존
피즈자넷엘리자베스
블록마이클하워드
노왁토르스텐
버로우스제레미니콜라스
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아스트라제네카 아베
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Priority claimed from GBGB9920814.2A external-priority patent/GB9920814D0/en
Priority claimed from GB0006641A external-priority patent/GB0006641D0/en
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Publication of KR20020067498A publication Critical patent/KR20020067498A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/42—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
KR1020027002841A 1999-09-04 2000-08-30 피루베이트 탈수소효소 활성을 증가시키는 치환된 ｎ-페닐2-히드록시-2-메틸-3,3,3-트리플루오로프로판아미드 유도체 Expired - Fee Related KR100692232B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9920814.2 1999-09-04
GBGB9920814.2A GB9920814D0 (en) 1999-09-04 1999-09-04 Chemical compounds
GB0006641.5 2000-03-21
GB0006641A GB0006641D0 (en) 2000-03-21 2000-03-21 Chemical compounds

Publications (2)

Publication Number Publication Date
KR20020067498A KR20020067498A (ko) 2002-08-22
KR100692232B1 true KR100692232B1 (ko) 2007-03-09

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KR1020027002841A Expired - Fee Related KR100692232B1 (ko) 1999-09-04 2000-08-30 피루베이트 탈수소효소 활성을 증가시키는 치환된 ｎ-페닐2-히드록시-2-메틸-3,3,3-트리플루오로프로판아미드 유도체

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US (1) US6689909B1 (enExample)
EP (1) EP1214296B1 (enExample)
JP (1) JP2003508515A (enExample)
KR (1) KR100692232B1 (enExample)
CN (1) CN1235877C (enExample)
AR (1) AR035163A1 (enExample)
AT (1) ATE262507T1 (enExample)
AU (1) AU760061B2 (enExample)
BG (1) BG65099B1 (enExample)
BR (1) BR0013694A (enExample)
CA (1) CA2381581A1 (enExample)
CO (1) CO5190690A1 (enExample)
CZ (1) CZ2002773A3 (enExample)
DE (1) DE60009319T2 (enExample)
DK (1) DK1214296T3 (enExample)
EE (1) EE05080B1 (enExample)
ES (1) ES2216940T3 (enExample)
HK (1) HK1045496B (enExample)
HU (1) HUP0202725A3 (enExample)
IL (2) IL148111A0 (enExample)
IS (1) IS2069B (enExample)
MX (1) MXPA02002319A (enExample)
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TR (1) TR200200550T2 (enExample)
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WO (1) WO2001017956A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE399753T1 (de) 1999-09-04 2008-07-15 Astrazeneca Ab Amide als pyruvatdehydrogenaseinhibitoren
GB0012012D0 (en) * 2000-05-19 2000-07-05 Astrazeneca Ab Chemical compound
GB0120471D0 (en) * 2001-08-23 2001-10-17 Astrazeneca Ab Chemical compounds
CA2471943C (en) * 2001-12-27 2011-09-20 Daiichi Pharmaceutical Co., Ltd. .beta.-amyloid protein production-secretion inhibitors
WO2012151448A1 (en) * 2011-05-03 2012-11-08 Agios Pharmaceuticals, Inc. Pyruvate kinase activators for use in therapy
EP2917207A1 (en) 2012-11-08 2015-09-16 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions and their use as pkm2 modulators
WO2014139144A1 (en) 2013-03-15 2014-09-18 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
SG11202001353PA (en) 2017-08-15 2020-03-30 Agios Pharmaceuticals Inc Pyruvate kinase modulators and use thereof
CN109096186B (zh) * 2018-09-29 2020-08-04 中南大学 一种2-芳磺酰基喹啉衍生物的合成方法
EP4438040A4 (en) * 2021-09-01 2025-08-20 Japan Tobacco Inc NITROGEN-CONTAINING TRICYCLIC COMPOUND AND ITS PHARMACEUTICAL USE

Citations (2)

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EP0524781A1 (en) * 1991-07-25 1993-01-27 Zeneca Limited Therapeutic amides
EP0617010A1 (en) * 1993-03-15 1994-09-28 Zeneca Limited Therapeutic compounds

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GB8617652D0 (en) 1986-07-18 1986-08-28 Ici Plc Acylanilide derivatives
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EP0539329A1 (de) 1991-10-25 1993-04-28 Ciba-Geigy Ag Acetylen-Verbindungen, verwendbar als Leukotrien-Antagonisten
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EP0524781A1 (en) * 1991-07-25 1993-01-27 Zeneca Limited Therapeutic amides
EP0617010A1 (en) * 1993-03-15 1994-09-28 Zeneca Limited Therapeutic compounds

Non-Patent Citations (1)

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Title
Journal of Medicinal Chemistry, 39(23), 1996

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EP1214296A1 (en) 2002-06-19
AU760061B2 (en) 2003-05-08
NZ517147A (en) 2003-11-28
BG65099B1 (bg) 2007-02-28
MY127036A (en) 2006-11-30
BG106520A (en) 2003-03-31
CO5190690A1 (es) 2002-08-29
DK1214296T3 (da) 2004-07-05
IL148111A0 (en) 2002-09-12
WO2001017956A1 (en) 2001-03-15
NO20021040D0 (no) 2002-03-01
PL353887A1 (en) 2003-12-15
IS2069B (is) 2005-11-15
ATE262507T1 (de) 2004-04-15
IL148111A (en) 2007-05-15
EE200200113A (et) 2003-06-16
PT1214296E (pt) 2004-08-31
HUP0202725A3 (en) 2005-04-28
RU2255085C2 (ru) 2005-06-27
SK3002002A3 (en) 2002-07-02
DE60009319T2 (de) 2005-03-31
IS6285A (is) 2002-02-26
HK1045496B (en) 2004-10-21
CA2381581A1 (en) 2001-03-15
NO20021040L (no) 2002-05-02
MXPA02002319A (es) 2002-07-30
EP1214296B1 (en) 2004-03-24
HK1045496A1 (en) 2002-11-29
ES2216940T3 (es) 2004-11-01
TW577867B (en) 2004-03-01
AU6854300A (en) 2001-04-10
CZ2002773A3 (cs) 2002-06-12
BR0013694A (pt) 2002-05-21
SK286774B6 (sk) 2009-05-07
RU2002108508A (ru) 2004-01-20
JP2003508515A (ja) 2003-03-04
TR200200550T2 (tr) 2002-06-21
HUP0202725A2 (hu) 2003-01-28
CN1235877C (zh) 2006-01-11
AR035163A1 (es) 2004-05-05
DE60009319D1 (de) 2004-04-29
KR20020067498A (ko) 2002-08-22
CN1387509A (zh) 2002-12-25
US6689909B1 (en) 2004-02-10
EE05080B1 (et) 2008-10-15

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St.27 status event code: A-4-4-U10-U13-oth-PC1903

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St.27 status event code: N-4-6-H10-H13-oth-PC1903

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