KR100542473B1 - 페린도프릴의 조절 방출을 위한 열성형가능한 고체 약제조성물 - Google Patents
페린도프릴의 조절 방출을 위한 열성형가능한 고체 약제조성물 Download PDFInfo
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- KR100542473B1 KR100542473B1 KR1020037008655A KR20037008655A KR100542473B1 KR 100542473 B1 KR100542473 B1 KR 100542473B1 KR 1020037008655 A KR1020037008655 A KR 1020037008655A KR 20037008655 A KR20037008655 A KR 20037008655A KR 100542473 B1 KR100542473 B1 KR 100542473B1
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- Prior art keywords
- perindopril
- controlled release
- solid pharmaceutical
- mixture
- pharmaceutical composition
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Description
회분 | |||
폴리메타크릴레이트 (조성의 98%) | 1 | 2 | 3 |
Eudragit(유드라지트) E100 | 98 | - | - |
Eudragit(유드라지트) RLPO | - | 98 | - |
Eudragit(유드라지트) RSPO | - | - | 98 |
Claims (15)
- 페린도프릴 또는 약제학적으로 허용되는 그 염과, 폴리메타크릴레이트의 군으로부터 선택된 하나 이상의 중합체의 열성형성 혼합물을 포함하고,상기 열성형성 혼합물에 사용된 폴리메타크릴레이트(들)이 소량의 4차 암모늄 기를 가지는 메타크릴산 에스테르 및 아크릴산의 완전 중합된 공중합체로 구성된 암모늄 메타크릴레이트의 공중합체; 1:2:0.2 및 1:2:0.1 비율의 폴리(에틸 아크릴레이트, 메틸 메타크릴레이트, 트리메틸아미노에틸 메타크릴레이트 클로라이드); 1:2:1 비율의 폴리(부틸 메타크릴레이트, (2-디메틸아미노에틸) 메타크릴레이트, 메틸 메타크릴레이트); 또는 1:1 비율의 폴리(메타크릴산, 메틸 메타크릴레이트), 1:1 비율의 폴리(메타크릴산, 에틸 아크릴레이트), 및/또는 1:2 비율의 폴리(메타크릴산, 메틸 메타크릴레이트)이고,상기 혼합물이 압출 성형 또는 사출 성형 기술에 따라 열성형되는 페린도프릴 또는 약제학적으로 허용되는 그 염의 조절 방출을 위한 고체 약제 조성물로서,페린도프릴의 방출이 단지 사용된 폴리메타크릴레이트(들)의 성질에 의해, 페린도프릴에 대한 폴리메타크릴레이트(들)의 양에 의해 그리고 상기 조성물의 제조에 적용된 기술에 의해 조절되는, 페린도프릴 또는 약제학적으로 허용되는 그 염의 조절 방출을 위한 고체 약제 조성물.
- 삭제
- 삭제
- 삭제
- 삭제
- 제 1항에 있어서, 조성물이 경구, 구강, 설하, 눈, 질, 직장 및 비경구 경로로부터 선택된 하나의 경로에 의해 투여가능함을 특징으로 하는 조절 방출성 고체 약제 조성물.
- 제 1항에 있어서, 조성물이 경구 경로에 의해 투여가능함을 특징으로 하는 조절 방출성 고체 약제 조성물.
- 제 1항에 있어서, 혼합물이 60℃ 내지 150℃로 열성형됨을 특징으로 하는 조절 방출성 고체 약제 조성물.
- 제 1항 또는 제 8항에 있어서, 혼합물이 80℃ 내지 130℃로 열성형됨을 특징으로 하는 조절 방출성 고체 약제 조성물.
- 삭제
- 삭제
- 제 1항에 있어서, 혼합물이 공동-압출 성형의 기술에 따라 열성형되고, 이 경우 조성물의 내층이 상기 혼합물로 구성되고 조성물의 외층이 하나 이상의 폴리메타크릴레이트(들) 또는 페린도프릴 또는 약제학적으로 허용되는 그 염과 혼합된 하나 이상의 폴리메타크릴레이트(들)로 구성됨을 특징으로 하는 조절 방출성 고체 약제 조성물.
- 제 1항에 있어서, 혼합물이 공동-사출 성형의 기술에 따라 열성형되고, 이 경우 조성물의 중심 부분이 상기 혼합물로 구성되고 조성물의 외층이 하나 이상의 폴리메타크릴레이트(들) 또는 페린도프릴 또는 약제학적으로 허용되는 그 염과 혼합된 하나 이상의 폴리메타크릴레이트(들)로 구성됨을 특징으로 하는 조절 방출성 고체 약제 조성물.
- 제 1항에 있어서, 항산화제, 향미제, 착색제, 방부제, 감미료 및 항점착제로부터 선택된 약리적으로 허용되는 하나 이상의 부형제를 임의로 포함함을 특징으로 하는 조절 방출성 고체 약제 조성물.
- 제 1항에 있어서, 페린도프릴이 tert-부틸아민 염의 형태임을 특징으로 하는 조절 방출성 고체 약제 조성물.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR00/17013 | 2000-12-26 | ||
FR0017013A FR2818550B1 (fr) | 2000-12-26 | 2000-12-26 | Composition pharmaceutique solide thermoformable pour la liberation controle de perindopril |
PCT/FR2001/004133 WO2002051407A1 (fr) | 2000-12-26 | 2001-12-21 | Composition pharmaceutique solide thermoformable pour la liberation controlee de perindopril |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20030064877A KR20030064877A (ko) | 2003-08-02 |
KR100542473B1 true KR100542473B1 (ko) | 2006-01-11 |
Family
ID=8858188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020037008655A KR100542473B1 (ko) | 2000-12-26 | 2001-12-21 | 페린도프릴의 조절 방출을 위한 열성형가능한 고체 약제조성물 |
Country Status (26)
Country | Link |
---|---|
US (1) | US20040115227A1 (ko) |
EP (1) | EP1345605B1 (ko) |
JP (1) | JP2004518666A (ko) |
KR (1) | KR100542473B1 (ko) |
CN (1) | CN1218696C (ko) |
AR (1) | AR031972A1 (ko) |
AT (1) | ATE299704T1 (ko) |
AU (1) | AU2002228118B2 (ko) |
BR (1) | BR0116536A (ko) |
CA (1) | CA2432896A1 (ko) |
CZ (1) | CZ297796B6 (ko) |
DE (1) | DE60112117T2 (ko) |
DK (1) | DK1345605T3 (ko) |
EA (1) | EA005139B1 (ko) |
ES (1) | ES2244672T3 (ko) |
FR (1) | FR2818550B1 (ko) |
HK (1) | HK1063739A1 (ko) |
HU (1) | HU230249B1 (ko) |
MX (1) | MXPA03005792A (ko) |
NO (1) | NO333590B1 (ko) |
NZ (1) | NZ526405A (ko) |
PL (1) | PL203836B1 (ko) |
PT (1) | PT1345605E (ko) |
SK (1) | SK286920B6 (ko) |
WO (1) | WO2002051407A1 (ko) |
ZA (1) | ZA200304405B (ko) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK50252005A3 (sk) * | 2005-03-22 | 2006-10-05 | Vúlm, A.S. | Farmaceutický prípravok obsahujúci perindopril erbumín, spôsob jeho prípravy a stabilizácie |
BRPI0615607A2 (pt) * | 2005-08-30 | 2011-05-24 | Lek Pharmaceuticals | composição farmacêutica compreendendo perindopril ou seus sais |
EP2750666B1 (en) * | 2011-08-30 | 2017-10-04 | Universiteit Gent | Multi-layered release formulation |
RU2670447C2 (ru) * | 2016-11-17 | 2018-10-23 | Общество с ограниченной ответственностью "Изварино Фарма" | Пероральная твердая лекарственная форма с микофенольной кислотой или ее солью для использования в качестве иммунодепрессанта для лечения или предупреждения отторжения трансплантата органа или ткани и способ ее получения |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5002776A (en) * | 1983-12-22 | 1991-03-26 | Elan Corporation, Plc | Controlled absorption diltiazem formulations |
DE4138513A1 (de) * | 1991-11-23 | 1993-05-27 | Basf Ag | Feste pharmazeutische retardform |
US5589499A (en) * | 1992-11-25 | 1996-12-31 | Weth; Gosbert | Dopaminergic agents for the treatment of cerebral and peripheral blood flow disorders |
US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
DE19724696A1 (de) * | 1997-06-12 | 1998-12-24 | Hexal Ag | Pharmazeutische Zubereitung mit drei Pelletarten |
GB9910773D0 (en) * | 1999-05-11 | 1999-07-07 | West Pharm Serv Drug Res Ltd | Novel single unit coated dosage forms that can be used to minimise the effect of food on the absorption of drugs from the gastrointestinal tract |
FR2795326B1 (fr) * | 1999-06-28 | 2001-08-31 | Adir | Composition pharmaceutique solide thermoformable a liberation controlee |
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2000
- 2000-12-26 FR FR0017013A patent/FR2818550B1/fr not_active Expired - Fee Related
-
2001
- 2001-12-21 AU AU2002228118A patent/AU2002228118B2/en not_active Ceased
- 2001-12-21 JP JP2002552552A patent/JP2004518666A/ja active Pending
- 2001-12-21 CA CA002432896A patent/CA2432896A1/fr not_active Abandoned
- 2001-12-21 PT PT01989653T patent/PT1345605E/pt unknown
- 2001-12-21 EP EP01989653A patent/EP1345605B1/fr not_active Expired - Lifetime
- 2001-12-21 EA EA200300664A patent/EA005139B1/ru not_active IP Right Cessation
- 2001-12-21 KR KR1020037008655A patent/KR100542473B1/ko not_active IP Right Cessation
- 2001-12-21 ES ES01989653T patent/ES2244672T3/es not_active Expired - Lifetime
- 2001-12-21 HU HU0302524A patent/HU230249B1/hu not_active IP Right Cessation
- 2001-12-21 PL PL361663A patent/PL203836B1/pl unknown
- 2001-12-21 CZ CZ20032008A patent/CZ297796B6/cs not_active IP Right Cessation
- 2001-12-21 AT AT01989653T patent/ATE299704T1/de active
- 2001-12-21 CN CNB018213723A patent/CN1218696C/zh not_active Expired - Fee Related
- 2001-12-21 US US10/451,937 patent/US20040115227A1/en not_active Abandoned
- 2001-12-21 DE DE60112117T patent/DE60112117T2/de not_active Expired - Lifetime
- 2001-12-21 DK DK01989653T patent/DK1345605T3/da active
- 2001-12-21 SK SK943-2003A patent/SK286920B6/sk not_active IP Right Cessation
- 2001-12-21 WO PCT/FR2001/004133 patent/WO2002051407A1/fr active IP Right Grant
- 2001-12-21 BR BR0116536-4A patent/BR0116536A/pt not_active IP Right Cessation
- 2001-12-21 MX MXPA03005792A patent/MXPA03005792A/es active IP Right Grant
- 2001-12-21 NZ NZ526405A patent/NZ526405A/xx not_active IP Right Cessation
- 2001-12-26 AR ARP010106028A patent/AR031972A1/es not_active Application Discontinuation
-
2003
- 2003-06-05 ZA ZA200304405A patent/ZA200304405B/en unknown
- 2003-06-16 NO NO20032738A patent/NO333590B1/no not_active IP Right Cessation
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2004
- 2004-09-03 HK HK04106635A patent/HK1063739A1/xx not_active IP Right Cessation
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