KR100527616B1 - 감미료 조성물 - Google Patents
감미료 조성물 Download PDFInfo
- Publication number
- KR100527616B1 KR100527616B1 KR10-2000-7012360A KR20007012360A KR100527616B1 KR 100527616 B1 KR100527616 B1 KR 100527616B1 KR 20007012360 A KR20007012360 A KR 20007012360A KR 100527616 B1 KR100527616 B1 KR 100527616B1
- Authority
- KR
- South Korea
- Prior art keywords
- apm
- crystals
- weight
- dissolution
- powder
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 33
- 235000003599 food sweetener Nutrition 0.000 title claims abstract description 24
- 239000003765 sweetening agent Substances 0.000 title claims abstract description 24
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims abstract description 72
- 108010011485 Aspartame Proteins 0.000 claims abstract description 68
- 239000000605 aspartame Substances 0.000 claims abstract description 68
- 235000010357 aspartame Nutrition 0.000 claims abstract description 68
- 229960003438 aspartame Drugs 0.000 claims abstract description 68
- HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 claims abstract description 7
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
- 239000013078 crystal Substances 0.000 claims description 61
- 238000004090 dissolution Methods 0.000 description 35
- 239000000843 powder Substances 0.000 description 29
- 239000002994 raw material Substances 0.000 description 13
- 238000000034 method Methods 0.000 description 9
- 238000002156 mixing Methods 0.000 description 9
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 8
- 229930006000 Sucrose Natural products 0.000 description 8
- 239000005720 sucrose Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 238000000634 powder X-ray diffraction Methods 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000000463 material Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- -1 3,3-dimethylbutyl Chemical group 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 206010013911 Dysgeusia Diseases 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 238000009776 industrial production Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000004384 Neotame Substances 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- UKVIEHSSVKSQBA-UHFFFAOYSA-N methane;palladium Chemical compound C.[Pd] UKVIEHSSVKSQBA-UHFFFAOYSA-N 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 235000019412 neotame Nutrition 0.000 description 1
- 108010070257 neotame Proteins 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
- A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Seasonings (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
NMC형 결정 단일물(원료 분말) | APM 단일물(원료 분말) | ||
NMC형 결정의 중량(g) | 용해 시간(분) | APM의 중량(g) | 용해 시간(분) |
1.000.900.500.100.030.005 | 62605540304 | 0.100.500.900.971.00- | 1020272930- |
혼합물(1g) | |||
APM 원료 분말의 함량(중량%) | APM의 중량(g) | NM의 중량(g) | 용해 시간(분) |
1050909799.5 | 0.100.500.900.970.995 | 0.900.500.100.030.005 | 251581825 |
NMA형 결정 단일물(원료 분말) | APM 단일물(원료 분말) | ||
NMA형 결정의 중량(g) | 용해 시간(분) | APM의 중량(g) | 용해 시간(분) |
1.000.900.500.100.030.005 | 4240351610- | 0.100.500.900.971.00- | 1020272930- |
혼합물(1g) | |||
APM 원료 분말의 함량(중량%) | APM의 중량(g) | NM의 중량(g) | 용해 시간(분) |
1050909799.5 | 0.100.500.900.970.995 | 0.900.500.100.030.005 | 3525232930 |
NMC형 결정 단일물(0.50g) | 별도 투입(총 1g)(NMC형 결정 0.5g/APM 원료 분말 0.5g) |
55분 | 55분 |
Claims (4)
- 유효 성분으로서 분말상 N-[N-(3,3-디메틸부틸)-L-α-아스파르틸]-L-페닐알라닌 1-메틸 에스테르와 분말상 아스파르탐을, 이들 둘 다의 합계량에 대한 아스파르탐의 비율이 10 내지 99.5중량%인 비율로 함유함을 특징으로 하는, 감미료 조성물.
- 제1항에 있어서, 분말상 N-[N-(3,3-디메틸부틸)-L-α-아스파르틸]-L-페닐알라닌 1-메틸 에스테르가 C형 결정임을 특징으로 하는, 감미료 조성물.
- 제2항에 있어서, N-[N-(3,3-디메틸부틸)-L-α-아스파르틸]-L-페닐알라닌 1-메틸 에스테르와 아스파르탐의 합계량에 대한 아스파르탐의 비율이 10 내지 97중량%임을 특징으로 하는, 감미료 조성물.
- 제2항에 있어서, N-[N-(3,3-디메틸부틸)-L-α-아스파르틸]-L-페닐알라닌 1-메틸 에스테르와 아스파르탐의 합계량에 대한 아스파르탐의 비율이 50 내지 97중량%임을 특징으로 하는, 감미료 조성물.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12598998A JP3643921B2 (ja) | 1998-05-08 | 1998-05-08 | 新規甘味料組成物 |
JP98-125989 | 1998-05-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20010043356A KR20010043356A (ko) | 2001-05-25 |
KR100527616B1 true KR100527616B1 (ko) | 2005-11-15 |
Family
ID=14923985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR10-2000-7012360A KR100527616B1 (ko) | 1998-05-08 | 1999-04-26 | 감미료 조성물 |
Country Status (12)
Country | Link |
---|---|
US (1) | US6372278B1 (ko) |
EP (1) | EP1075797B1 (ko) |
JP (1) | JP3643921B2 (ko) |
KR (1) | KR100527616B1 (ko) |
CN (1) | CN1134225C (ko) |
AT (1) | ATE269004T1 (ko) |
BR (1) | BR9910301A (ko) |
CA (1) | CA2331768C (ko) |
DE (1) | DE69918098T2 (ko) |
HU (1) | HUP0102090A3 (ko) |
RU (1) | RU2220153C2 (ko) |
WO (1) | WO1999057998A1 (ko) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020037350A1 (en) * | 1997-03-10 | 2002-03-28 | Shoichi Ishii | Sweetener composition improved in taste |
US6692778B2 (en) | 1998-06-05 | 2004-02-17 | Wm. Wrigley Jr. Company | Method of controlling release of N-substituted derivatives of aspartame in chewing gum |
BR9914826A (pt) | 1998-10-30 | 2001-11-06 | Ajinomoto Kk | Processo de cristalização de cristais de éster metìlico de n- [n-(3,3-dimetilbutil)-l-alfa-aspartil] -l-fenilalanina |
US6048999A (en) * | 1999-01-25 | 2000-04-11 | The Nutrasweet Company | N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester synergistic sweetener blends |
AU4038800A (en) * | 1999-03-29 | 2000-10-16 | Nutrasweet Company, The | Nutraceuticals having |
WO2001028590A2 (en) * | 1999-10-19 | 2001-04-26 | The Nutrasweet Company | PHARMACEUTICAL COMPOSITIONS CONTAINING N-[N-(3,3-DIMETHYLBUTYL)-1-α-ASPARTYL]-L-PHENYLALANINE METHYL ESTER |
KR100520438B1 (ko) * | 2003-11-10 | 2005-10-11 | 대상 주식회사 | 저장안정성과 감미질이 개선된 설탕대체용 감미료 조성물및 그 제조방법 |
US9220291B2 (en) | 2006-09-30 | 2015-12-29 | Tropicana Products, Inc. | Method of producing a reduced-calorie food product |
US20080085351A1 (en) * | 2006-10-04 | 2008-04-10 | Pepsico, Inc. | Calorie reduced beverages employing a blend of neotame and acesulfame-K |
WO2012026499A1 (ja) * | 2010-08-25 | 2012-03-01 | 味の素株式会社 | アスパルチルジペプチドエステル誘導体の保存方法及び安定化剤 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2697844B1 (fr) * | 1992-11-12 | 1995-01-27 | Claude Nofre | Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation. |
JP3651161B2 (ja) * | 1997-03-10 | 2005-05-25 | 味の素株式会社 | 改善された呈味を有する甘味料組成物 |
US6048999A (en) * | 1999-01-25 | 2000-04-11 | The Nutrasweet Company | N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester synergistic sweetener blends |
-
1998
- 1998-05-08 JP JP12598998A patent/JP3643921B2/ja not_active Expired - Fee Related
-
1999
- 1999-04-26 AT AT99917150T patent/ATE269004T1/de not_active IP Right Cessation
- 1999-04-26 CN CNB998059005A patent/CN1134225C/zh not_active Expired - Fee Related
- 1999-04-26 DE DE69918098T patent/DE69918098T2/de not_active Expired - Lifetime
- 1999-04-26 KR KR10-2000-7012360A patent/KR100527616B1/ko not_active IP Right Cessation
- 1999-04-26 EP EP99917150A patent/EP1075797B1/en not_active Expired - Lifetime
- 1999-04-26 BR BR9910301-0A patent/BR9910301A/pt not_active Application Discontinuation
- 1999-04-26 HU HU0102090A patent/HUP0102090A3/hu unknown
- 1999-04-26 WO PCT/JP1999/002198 patent/WO1999057998A1/ja active IP Right Grant
- 1999-04-26 RU RU2000131182/04A patent/RU2220153C2/ru active
- 1999-04-26 CA CA002331768A patent/CA2331768C/en not_active Expired - Fee Related
-
2000
- 2000-11-08 US US09/707,953 patent/US6372278B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6372278B1 (en) | 2002-04-16 |
RU2220153C2 (ru) | 2003-12-27 |
JP3643921B2 (ja) | 2005-04-27 |
EP1075797B1 (en) | 2004-06-16 |
EP1075797A9 (en) | 2001-04-04 |
KR20010043356A (ko) | 2001-05-25 |
CN1299240A (zh) | 2001-06-13 |
WO1999057998A1 (fr) | 1999-11-18 |
ATE269004T1 (de) | 2004-07-15 |
CA2331768C (en) | 2008-06-17 |
DE69918098D1 (de) | 2004-07-22 |
BR9910301A (pt) | 2001-09-25 |
CA2331768A1 (en) | 1999-11-18 |
HUP0102090A2 (hu) | 2001-10-28 |
JPH11318381A (ja) | 1999-11-24 |
DE69918098T2 (de) | 2005-02-17 |
EP1075797A1 (en) | 2001-02-14 |
HUP0102090A3 (en) | 2003-01-28 |
CN1134225C (zh) | 2004-01-14 |
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