KR100522289B1 - 변형된 ＴＮＦα 분자, 이러한 변형된 ＴＮＦα 분자를 코드화하는 ＤＮＡ 및 이러한 변형된 ＴＮＦα 분자 및 ＤＮＡ를 포함하는 백신 - Google Patents

변형된 ＴＮＦα 분자, 이러한 변형된 ＴＮＦα 분자를 코드화하는 ＤＮＡ 및 이러한 변형된 ＴＮＦα 분자 및 ＤＮＡ를 포함하는 백신 Download PDF

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Publication number
KR100522289B1
KR100522289B1 KR10-1999-7009504A KR19997009504A KR100522289B1 KR 100522289 B1 KR100522289 B1 KR 100522289B1 KR 19997009504 A KR19997009504 A KR 19997009504A KR 100522289 B1 KR100522289 B1 KR 100522289B1
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KR
South Korea
Prior art keywords
tnfα
molecule
leu
sequence
human tnfα
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR10-1999-7009504A
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English (en)
Korean (ko)
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KR20010006416A (ko
Inventor
마르틴 롤란드 옌센
조렌 모우리트센
헨릭 엘스너
이벤 다룸
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파멕사 에이/에스
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/144—Tumor necrosis factor

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR10-1999-7009504A 1997-04-15 1998-04-15 변형된 ＴＮＦα 분자, 이러한 변형된 ＴＮＦα 분자를 코드화하는 ＤＮＡ 및 이러한 변형된 ＴＮＦα 분자 및 ＤＮＡ를 포함하는 백신 Expired - Fee Related KR100522289B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DK0418/97 1997-04-15
DK41897 1997-04-15
US4418797P 1997-04-24 1997-04-24
US60/044,187 1997-04-24
PCT/DK1998/000157 WO1998046642A1 (en) 1997-04-15 1998-04-15 MODIFIED TNFα MOLECULES, DNA ENCODING SUCH MODIFIED TNFα MOLECULES AND VACCINES COMPRISING SUCH MODIFIED TNFα MOLECULES AND DNA

Publications (2)

Publication Number Publication Date
KR20010006416A KR20010006416A (ko) 2001-01-26
KR100522289B1 true KR100522289B1 (ko) 2005-10-19

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Family Applications (1)

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KR10-1999-7009504A Expired - Fee Related KR100522289B1 (ko) 1997-04-15 1998-04-15 변형된 ＴＮＦα 분자, 이러한 변형된 ＴＮＦα 분자를 코드화하는 ＤＮＡ 및 이러한 변형된 ＴＮＦα 분자 및 ＤＮＡ를 포함하는 백신

Country Status (29)

Country Link
US (1) US7118750B1 (enExample)
EP (1) EP0975668B1 (enExample)
JP (1) JP2001521386A (enExample)
KR (1) KR100522289B1 (enExample)
CN (1) CN1178955C (enExample)
AR (1) AR012427A1 (enExample)
AT (1) ATE326481T1 (enExample)
AU (1) AU743400B2 (enExample)
BR (1) BR9811462A (enExample)
CA (1) CA2289476A1 (enExample)
CZ (1) CZ9903657A3 (enExample)
DE (1) DE69834556T2 (enExample)
DK (1) DK0975668T3 (enExample)
EE (1) EE9900461A (enExample)
ES (1) ES2264569T3 (enExample)
HR (1) HRP980203B1 (enExample)
HU (1) HUP0001930A3 (enExample)
IL (1) IL132281A0 (enExample)
NO (1) NO995002L (enExample)
NZ (1) NZ337955A (enExample)
PL (1) PL194221B1 (enExample)
RU (1) RU2241715C2 (enExample)
SI (1) SI0975668T1 (enExample)
SK (1) SK285639B6 (enExample)
TR (1) TR199902562T2 (enExample)
TW (1) TW510921B (enExample)
UA (1) UA72440C2 (enExample)
WO (1) WO1998046642A1 (enExample)
ZA (1) ZA983148B (enExample)

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TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US6913749B2 (en) 1998-11-02 2005-07-05 Resistentia Pharmaceuticals Ab Immunogenic polypeptides for inducing anti-self IgE responses
PT1159003E (pt) * 1999-03-02 2011-02-22 Centocor Inc Anti-tnf alfa na terapêutica da asma resistente a esteróides
US20040220103A1 (en) 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
WO2000067777A1 (en) * 1999-05-07 2000-11-16 Biofan Pty Ltd A method of prophylaxis and treatment and agents useful therefor
EE200200025A (et) 1999-07-20 2003-04-15 Pharmexa A/S Meetod GDF-8 aktiivsuse allareguleerimiseks, meetod looma lihasmassi suurendamiseks, GDF-8 analoog,immunogeenne kompositsioon, nukleiinhappefragment, vektor, transformeeritud rakk ja selle valmistamismeetod, kompositsioon GDF-8 vastaste antikehadeto
AU2001265830A1 (en) * 2000-06-21 2002-01-02 Ferring, B.V. Solubilised protein vaccines
AU2003208314A1 (en) * 2002-03-11 2003-09-22 Pharmexa A/S Novel application of vaccination against tnf-alpha
FR2844514B1 (fr) * 2002-09-16 2007-10-19 Neovacs Produit immunogene stable comprenant des heterocomplexes antigeniques, compositions les contenant et procede de preparation
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7563810B2 (en) * 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
KR20050118669A (ko) * 2003-02-01 2005-12-19 뉴랄랩 리미티드 가용성 ａ-베타에 대한 항체를 생성하기 위한 능동 면역화
WO2005084198A2 (en) 2004-02-27 2005-09-15 Vaxconsulting Peptides of il1 beta and tnf alpha and method of treatment using same
EP1838348B1 (en) 2004-12-15 2013-06-26 Janssen Alzheimer Immunotherapy Humanized amyloid beta antibodies for use in improving cognition
JP5757495B2 (ja) 2005-05-16 2015-07-29 アッヴィ バイオテクノロジー リミテッド びらん性多発性関節炎の治療のためのｔｎｆ阻害剤の使用
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
KR20100084623A (ko) * 2007-09-25 2010-07-27 인터벳 인터내셔널 비.브이. 골관절염 치료용 백신
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
CA2780130A1 (en) 2009-11-05 2011-05-12 The Uab Research Foundation Treating basal-like genotype cancers
US8703712B2 (en) 2010-03-18 2014-04-22 The Uab Research Foundation Targeting cancer stem cells with DR5 agonists
US8907053B2 (en) * 2010-06-25 2014-12-09 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
EP2648746A1 (en) 2010-12-08 2013-10-16 Neovacs Strongly inactivated and still highly immunogenic vaccine and process of manufacturing thereof
EP2462950A1 (en) 2010-12-08 2012-06-13 Neovacs Strongly inactivated and still highly immunogenic vaccine, and process of manufacturing thereof
CN102539778A (zh) * 2010-12-24 2012-07-04 北京义翘神州生物技术有限公司 一种检测人肿瘤坏死因子-α的酶联免疫试剂盒
JP2011201902A (ja) * 2011-05-19 2011-10-13 Wyeth Llc 可溶性Ａ−βに対する抗体を生成させるための能動免疫
CN103376327A (zh) * 2012-04-28 2013-10-30 通用电气公司 检测抗体或融合蛋白的浓度的方法
WO2016179430A1 (en) 2015-05-05 2016-11-10 Rubicon Biotechnology Llc Cancer immunotherapeutic
CN106279403B (zh) * 2016-08-16 2019-06-11 长春市海兰深生物医学技术有限公司 一种检测天然肺癌相关抗体的组合物、试剂盒和方法
CN106478802B (zh) * 2016-10-11 2019-08-09 浙江省人民医院 TNF-α蛋白B细胞表位，含此表位的多抗原肽及应用

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WO1995005849A1 (en) * 1993-08-26 1995-03-02 Mouritsen & Elsner A/S Inducing antibody response against self-proteins with the aid of foreign t-cell epitopes

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US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
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CA2119089A1 (en) * 1993-03-29 1994-09-30 David Banner Tumor necrosis factor muteins

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO1995005849A1 (en) * 1993-08-26 1995-03-02 Mouritsen & Elsner A/S Inducing antibody response against self-proteins with the aid of foreign t-cell epitopes

Also Published As

Publication number Publication date
HK1022918A1 (en) 2000-08-25
ATE326481T1 (de) 2006-06-15
EP0975668B1 (en) 2006-05-17
TR199902562T2 (xx) 2000-02-21
DE69834556D1 (de) 2006-06-22
PL194221B1 (pl) 2007-05-31
CN1252809A (zh) 2000-05-10
BR9811462A (pt) 2000-09-12
NO995002L (no) 1999-12-15
KR20010006416A (ko) 2001-01-26
IL132281A0 (en) 2001-03-19
NZ337955A (en) 2000-09-29
DE69834556T2 (de) 2007-05-10
HUP0001930A2 (hu) 2000-09-28
NO995002D0 (no) 1999-10-14
ES2264569T3 (es) 2007-01-01
EP0975668A1 (en) 2000-02-02
RU2241715C2 (ru) 2004-12-10
CN1178955C (zh) 2004-12-08
PL336295A1 (en) 2000-06-19
SK140999A3 (en) 2000-06-12
JP2001521386A (ja) 2001-11-06
AR012427A1 (es) 2000-10-18
HRP980203B1 (en) 2003-04-30
US7118750B1 (en) 2006-10-10
HUP0001930A3 (en) 2001-10-29
AU7030398A (en) 1998-11-11
WO1998046642A1 (en) 1998-10-22
UA72440C2 (en) 2005-03-15
TW510921B (en) 2002-11-21
HRP980203A2 (en) 1998-12-31
SK285639B6 (sk) 2007-05-03
AU743400B2 (en) 2002-01-24
CA2289476A1 (en) 1998-10-22
CZ9903657A3 (cs) 2001-09-12
EE9900461A (et) 2000-06-15
DK0975668T3 (da) 2006-09-25
ZA983148B (en) 1999-10-15
SI0975668T1 (sl) 2007-02-28

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