KR100503925B1 - Natural substances compositions for promotion of the growth of useful enterobacteria having an anti-oxidative activities - Google Patents

Natural substances compositions for promotion of the growth of useful enterobacteria having an anti-oxidative activities Download PDF

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KR100503925B1
KR100503925B1 KR10-2001-0046355A KR20010046355A KR100503925B1 KR 100503925 B1 KR100503925 B1 KR 100503925B1 KR 20010046355 A KR20010046355 A KR 20010046355A KR 100503925 B1 KR100503925 B1 KR 100503925B1
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green tea
cornus
dermis
growth
bifidobacterum
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KR20030012359A (en
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김종덕
김민용
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김종덕
김민용
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/16—Tea extraction; Tea extracts; Treating tea extract; Making instant tea
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F2200/00—Special features
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/145—Clostridium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus
    • C12R2001/23—Lactobacillus acidophilus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus
    • C12R2001/25—Lactobacillus plantarum

Abstract

본 발명은 항산화 효과를 가지면서 동시에 장내에서 유용한 세균의 성장을 촉진시켜 이들 유용세균들이 생산하는 유용물질에 의해 생체의 대사작용을 향상시켜 건강을 유지할 수 있게 하는 효과를 갖는 기능성 조성물에 관한 것으로, 백작약, 백출, 음양곽, 석창포, 진피, 당귀, 오가피, 구기자, 계피, 괴화, 황백, 연자육, 천문동, 상백피, 승마, 갈근, 녹차, 감초, 황기, 황금, 산수유, 현초, 황련, 오미자, 사간, 두충, 오배자, 백굴채, 고삼 및 산사자로 이루어진 군에서 선택된 1종 이상을 함유하는 것을 특징으로 한다. The present invention relates to a functional composition having an antioxidant effect and at the same time to promote the growth of useful bacteria in the intestine to improve the metabolism of the living body by the useful substances produced by these useful bacteria to maintain health, White peony, baekryeum, yin and yangkok, changchangpo, dermis, donkey, ogapi, wolfberry, cinnamon, chrysanthemum, yellow white, lotus root, cheonmundong, baekbaekpi, horseback riding, brown root, green tea, licorice, astragalus, golden, cornus, hyacinth, yellow lotus, schisandra It is characterized in that it contains at least one selected from the group consisting of two larvae, baejaja, baekchulchae, gosam and mountain lion.

Description

항산화성을 갖는, 장내 세균 성장촉진용 조성물{Natural substances compositions for promotion of the growth of useful enterobacteria having an anti-oxidative activities}Natural substances compositions for promotion of the growth of useful enterobacteria having an anti-oxidative activities}

본 발명은 항산화 효과를 가지면서 동시에 장내 유용 세균의 성장을 촉진하는 효과를 갖는 기능성 조성물에 관한 것이다. The present invention relates to a functional composition having an antioxidant effect and at the same time having an effect of promoting the growth of enteric useful bacteria.

생체가 기능을 유지하기 위한 필수의 과정, 즉, 호흡과정 등의 에너지 생성과정, 외부 물질 유입에 의한 면역활동, 화학물질 등의 간에서의 무독화과정, 운동등의 산소량 증가 등에 의하여 자유 라디칼(유해산소)이 많이 발생한다. 그런데, 이 자유라디칼이란 전자궤도에서 짝을 짓지 않고 있는 전자쌍을 1개 이상 가지고 있는 원자나 분자를 말하는데, 이 자유라디칼이 짝을 짓기 위해서는 생체의 어떠한 구성 성분으로부터 전자를 뺏어서 짝을 이루지만 전자를 빼앗긴 구성성분은 산화되어 그 기능이 퇴화되거나 사멸됨으로써 그 조직은 점차 노화되거나 질병이 발생되는 등 제기능을 다하지 못하게 된다. Free radicals are required by vital processes for maintaining the function of the living body, that is, energy generation process such as respiratory process, immune activity by inflow of foreign substances, detoxification process of liver of chemicals, etc. Lots of harmful oxygen). By the way, this free radical refers to an atom or molecule that has one or more pairs of electrons that are not paired in the electron orbit. In order to make a pair, the free radicals are paired by extracting electrons from any constituent of the living body. Deprived components are oxidized and their function degrades or dies, so that the tissues are gradually unable to function, such as aging or disease.

따라서, 이러한 자유 라디칼들을 제거할 필요가 있으며, 이와 같이 자유라디칼을 제거할 목적으로 많은 항산화제(antioxidant)들이 개발되었다. Therefore, there is a need to remove these free radicals, and many antioxidants have been developed for the purpose of removing such free radicals.

그러나, 노화 등을 방지할 목적으로 자유라디칼의 제거를 위해 생체에 투여되는 항산화제들은 장내세균의 제어에 대하여 언급이 없었으며, 이에 따른 생체에 필요한 유용한 균주들의 불균형에 의하여 생체는 기능의 저하에 따른 여러 가지의 질병을 일으켜 왔다. 더구나, 제어되어진 유용세균들이 균형을 이루려면 시간이 많이 소요되고, 그 시간 동안에 생체는 유용세균이 제공하는 유용물질들은 공급받지 못하여 여러 가지 질병의 원인이 되어 왔을 뿐만 아니라 불균형을 이룬 유용세균들을 회복시킬 수 있는 뚜렷한 방법이 없었다. However, the antioxidants administered to the living body for the removal of free radicals for the purpose of preventing aging did not mention the control of enterobacteriaceae, and thus the living body may be deteriorated due to the imbalance of useful strains necessary for the living body. Has caused various diseases. Moreover, it takes a long time for the controlled useful bacteria to be balanced, during which time the living organisms have not been supplied with the useful materials provided by the useful bacteria and have caused various diseases as well as recovering the imbalanced useful bacteria. There was no obvious way to do this.

따라서, 본 발명자들은 항산화 효과를 가지면서 동시에 장내에서 유용한 세의 성장을 촉진시켜 이들 유용세균들이 생산하는 유용물질에 의해 생체의 대사작용을 향상시켜 건강을 유지할 수 있게 하는 효과도 갖는 물질을 찾고자 연구하게 되었고, 그 결과, 생약재들 중에서 백작약, 백출, 음양곽, 석창포, 진피, 당귀, 오가피, 구기자, 계피, 괴화, 황백, 연자육, 천문동, 상백피, 승마, 갈근, 녹차, 감초, 황기, 황금, 산수유, 현초, 황련, 오미자, 사간, 두충, 오배자, 백굴채, 고삼 및 산사자로 이루어진 군에서 선택된 1종 이상이 항산화 효과와 장내 유용세균의 성장 촉진 효과를 동시에 가짐을 발견하고 본 발명을 완성하게 되었다.Therefore, the present inventors have studied to find a substance that has an antioxidant effect and also promotes the growth of useful tax in the intestine, thereby improving the metabolism of the living body by the useful substances produced by these useful bacteria to maintain health. As a result, among the herbal medicines, Earl, Baekchul, Yin Yang Kwak, Seokpo, Dermis, Angelica, Ogapi, Wolfberry, Cinnamon, Gochu, Yellow white, Yeonjak, Astronomical dong, Sangbaekpi, Horse riding, Brown root, Green tea, Licorice, Astragalus, Golden, Cornus At least one member selected from the group consisting of hyundai, rhubarb, Schisandra chinensis, sagan, tofu, locust, Baekchulchae, red ginseng and mountain lion has been found to have both antioxidant effect and growth promoting effect of enterobacteriaceae. .

따라서, 본 발명의 목적은 항산화 효과를 가지면서 동시에 장내에서 유용한 세균의 성장을 촉진시킬 수 있는 기능성 조성물을 제공하는 것이다. Accordingly, it is an object of the present invention to provide a functional composition capable of promoting the growth of useful bacteria in the intestine while having an antioxidant effect.

상기한 목적을 달성하기 위해서, 본 발명의 기능성 조성물은 백작약, 백출, 음양곽, 석창포, 진피, 당귀, 오가피, 구기자, 계피, 괴화, 황백, 연자육, 천문동, 상백피, 승마, 갈근, 녹차, 감초, 황기, 황금, 산수유, 현초, 황련, 오미자, 사간, 두충, 오배자, 백굴채, 고삼 및 산사자로 이루어진 군에서 선택된 1종 이상을 포함하는 것을 특징으로 한다. In order to achieve the above object, the functional composition of the present invention is Baekjak, Baekchul, Eumyangkwa, Seokchangpo, Dermis, Angelica, Ogapi, Gugija, cinnamon, chrysanthemum, yellow white, lotus root, cheonmundong, Sangbaekpi, horseback riding, brown root, green tea, licorice, Astragalus, Golden, Cornus, Hyeoncho, Hwangnyeon, Schisandra chinensis, Sagan, Tofu, Ginseng, Baekchulchae, Gosam and mountain lions, characterized in that it comprises one or more selected from the group consisting of.

이하, 본 발명을 보다 상세히 설명한다. Hereinafter, the present invention will be described in more detail.

본 발명의 조성물은 생체내에 존재하는 자유 라디칼을 제거하여 자유 라디칼에 의한 노화 및 질병의 발생 등을 방지할 수 있으면서, 동시에 장내 유용 세균의 성장을 촉진시켜 자유 라디칼의 제거시 생체내의 유용한 세균들도 같이 제거되어 생체내 대사장애를 유발하는 문제점도 해결한 기능성 조성물로서, 이들의 분말을 팩 형태의 차로서 제공하거나 이들의 열수추출물을 음료 및 식품으로서 제공할 수 있다.The composition of the present invention can remove the free radicals present in the living body to prevent aging and the occurrence of diseases caused by the free radicals, and at the same time to promote the growth of useful bacteria in the intestine and also to remove the free radicals. As a functional composition that is also eliminated as a problem to cause metabolic disorders in vivo, these powders may be provided as tea in the form of a pack or their hot water extracts may be provided as beverages and foods.

본 발명의 조성물에 포함되는 생약재들은 다음과 같은 특성을 갖는다. The herbal medicines included in the composition of the present invention have the following characteristics.

백작약(白芍藥, Paenoia japonica)은 한국·일본·중국·사할린섬 등지에 분포하는 미나리아재비목 미나리아재비과의 여러해살이풀로서, 강작약이라고도 하는데, 뿌리를 진통·진경·부인병에 사용한다. Paengia japonica is a perennial herb of the Ranunculus herbaceous family, distributed in Korea, Japan, China, and Sakhalin Island. It is also known as a potent plant and its roots are used for pain relief , dysfunction , and gynecological diseases.

백출(白朮, Atractylodis rhizoma alba)은 산지의 건조한 곳에서 자라는 국화과의 다년초인 삽주의 뿌리를 한방에서 이르는 말로 소화관 및 피하조직에서 일어나는 수분대사(水分代謝)의 부전(不全)에 대하여 이뇨(利尿)·발한(發汗) 작용을 하며, 동통·위장염·부종에 효험이 있고 알려져 있다.Baekchul ( Atractylodis rhizoma alba ) refers to the root of a perennial herb of asteraceae, which grows in dry places in the mountains. It is a diuretic for the failure of water metabolism in the digestive tract and subcutaneous tissue. · It has a sweating effect and is known for its effects on pain, gastroenteritis and edema.

음양곽(Epimedii herba)은 삼지구엽초라고도 하며, 두뇌활동을 돕고 건망증, 무기력증에 효과가 있다. 피로회복, 식욕부진, 히스테리에 효과가 있다고 알려져 있다. 또한, 신과 양기를 보(補)하여 정력을 증진시키는 생약재로도 알려져 있다. Epimedii herba , also known as trilobite vinegar , helps brain activity and is effective in forgetfulness and lethargy. It is known to have effects on fatigue, anorexia and hysteria. In addition, it is also known as a herbal medicine that promotes energy by giving God and Yang.

석창포(石菖蒲, Acori graminei rhizoma)는 한국(중부지방 이남)·일본·중국·인도 등지에 널리 분포하는 천남성목 천남성과의 여러해살이풀로, 한방에서는 뿌리줄기를 진통제·진정제·건위제로 사용하고, 민간에서는 목욕물에 넣어 사용하기도 한다. Seokchangpo (石菖蒲, Acori graminei rhizoma ) is a perennial plant of Chunnamseong , which is widely distributed in Korea (sub-Central region), Japan, China, India, etc. In oriental medicine, root stems are used as analgesics, soothing agents, and health agents. In the private sector, it is used in bath water.

진피(陳皮, Aurantti nobilis pericarpium)는 온주밀감(溫州蜜柑)의 숙과피를 건조한 것으로 진귤피(陳橘皮)라고도 한다. 아직 덜 익은 파란 과피는 청귤피라고 하며, 황숙한 과피를 진피(진귤피)라고 한다. 진(陳)은 노숙(老熟)의 뜻을 가진다. 성분은 정유·헤스베리딘이다. 한의학에서는 채취 후 1년 정도 경과한 향기가 강한 것을 상품(上品)으로 취급하며, 방향성의 건위제 외에, 진토(鎭吐)·진해·거담제로서 1일 5∼10g을 사용한다.Dermis (陳 rant, Aurantti nobilis pericarpium ) is a dried dried ripening skin of Wenzhou persimmon (溫州 蜜柑), also known as jingyupi (陳 橘皮). The unripe blue rind is called tangerine peel, and the ripe rind is called dermis. Jin has the meaning of homelessness. The ingredient is essential oil and hesburydine. In oriental medicine, strong aromas that have elapsed for about a year after collection are treated as commodities, and in addition to aromatic dry matter, 5-10 g per day is used as a jinto, antitussive, and expectorant.

당귀(Angelicae giantis radix)는 이판화군 산형화목 미나리과의 여러해살이풀로, 진통·배농(排膿)·지혈·강장작용이 있으므로 복통·종기·타박상 및 부인병에 효능이 있다고 알려져 있다. Angelicae giantis radix is a perennial herb of the genus Amanaceae, which is known to be effective in abdominal pain, boils, bruises and gynecological diseases due to its analgesic, drainage, hemostatic and tonic effects.

구기자(Lycii fructus)는 구기자 나무(Lycium chinense)의 열매를 말린 것으로, 술을 담아 강장제로 쓴인다. Lycii fructus is a dried fruit of Lycium chinense , which is used as a tonic in alcohol.

오가피(五加皮, Acanthodanacis cortex)는 한방에서 보약, 정신 및 육체적 피로와 병후 쇠약에 쓴다. 또, 하반신에 작용하는 강장제나 진통제, 관절류머티즘, 요통 등에도 쓰는 약재이다.Ogapi (五 加 cor, Acanthodanacis cortex ) is used for herbal medicine, mental and physical fatigue and debilitating illnesses. It is also a herb used in tonics, analgesics, joint rheumatism and back pain, which act on the lower body.

계피(Cinnamomi cortex)는 계수나무의 뿌리·줄기·가지 등의 껍질을 벗겨서 말리거나, 껍질을 벗기지 않고 건조시킨 가느다란 가지[桂枝]를 말한다. 계피는 방향성(芳香性)의 건위제(健胃劑)로서 그 분말을 다른 산제(散劑)와 배합하여 식욕 증진제로 사용한다. 한편, 한방에서는 땀이 나게 하고 식은땀을 거두게 하는 이 약재를 계지탕·갈근탕(칡뿌리탕)에 배합하며, 특히 감기를 포함한 소화기와 순환기 질환·급성열병·노인병 등에 첨가하여 사용한다.Cinnamon ( Cinnamomi cortex ) refers to thin branches dried by peeling the roots, stems and branches of cassia, or dried without peeling. Cinnamon is an aromatic dry agent, and its powder is mixed with other powders to be used as an appetite enhancer. On the other hand, in Chinese medicine, this medicine, which makes sweat and cool sweat, is mixed with Gyeji-tang and Galgeun-tang (Jung-Puri-Tang), and is especially used in addition to digestive and circulatory diseases including a cold, acute fever and elderly diseases.

괴화(Sophorae flos)는 고혈압시 모세혈관의 저항력을 증강시켜 뇌혈관의 파열을 방지하는데 효능이 있다고 알려져 있는 약재이다. Sophorae flos is a drug known to be effective in preventing cerebrovascular rupture by enhancing capillary resistance during hypertension.

황백(Phellodendri cortex)은 갈잎큰키나무, 황벽나무, 피나무 등의 나무 껍질을 말한다. 습열로 인한 황달과 이질, 대하 및 염증으로 인해 다리와 무릎이 붓고 아프며 무겁고 마비되는 증상에 유효하다. 또한, 종기, 습진, 화상 및 눈이 충혈되고 통증을 호소하는 질환에도 효과가 있다고 알려져 있다.Phellodendri cortex refers to the bark of leaves such as larch, tall wall and blood tree. It is effective for jaundice and dysentery caused by moist fever, swelling, soreness and inflammation of legs and knees. It is also known to be effective for diseases that cause redness and pain in boils, eczema, burns and eyes.

연자육(蓮子肉, Nelumbo nuclfera gaertner)은 연꽃의 열매를 말하는데, 기(氣)의 보충에도 아주 좋으며 피부 질환 퇴치와 미용, 내장 기능 강화, 마음의 안정과 정신력 강화,두뇌 기능 향상, 설사, 신체 허약 등에도 아주 좋다. 흔히 연자육이라고 하면 남성들의 강정에만 좋은 것으로 알고 있는 사람들이 많으나, 연자육은 여성들의 강정 식품으로도 아주 효과적이다. 특히 심리적인 요인이나 스트레스 등으로 생긴 여성들의 성욕 감퇴와 성기능 저하, 섹스 기피증, 방사에 대한 불안감, 불감증, 신기(驛氣) 쇠약 등 성적 장애에 아주 좋은 효능을 발휘하는 약재이다. Nelumbo nuclfera gaertner (열매 子 열매 ) refers to the fruit of the lotus, which is also very good for supplementation of chi (氣) and combats skin diseases and beauty, strengthens visceral function, strengthens the mind and strengthens the brain, improves brain function, diarrhea and physical weakness. Very good for back. Many people think that it is only good for men's gangjeong, but it is also very effective for women's gangjeong food. In particular, it is a medicine that is very effective in sexual disorders such as decreased sexual desire, sexual dysfunction, sexual evasion, radiation anxiety, insensitivity, and weakness caused by psychological factors or stress.

천문동(Asparagi tuber)은 백합목 백합과의 여러해살이풀로, 연한 순을 식용하며 뿌리를 진해·이뇨·강장제로 사용한다. Asparagi tuber is a perennial herb of the liliaceae genus , edible in light turn, and used as root, diuretic, tonic.

상백피(桑白皮, Mori cortex radicis)는 뽕나무 껍질로, 폐열을 내리고 기침을 멈추며 숨찬 증세를 낫게 하고 소변을 잘 보게 하는 효능이 있다. 또한, 폐열로 기침이 나고 숨이 찬 데, 피가래, 붓는데, 고혈압 등에도 효능이 있다. Mori cortex radicis ( Mori cortex radicis ) is a mulberry bark that lowers the heat of the lungs , stops coughing, improves the symptoms of breathing , and urinates well. In addition, coughing and breathing in the lung fever, blood sputum, swelling, high blood pressure is also effective.

승마(升麻, Cimicifugae Rhizoma)는 미나리아재비목 미나리아재비과의 여러해살이풀로, 한방에서 이 풀의 뿌리를 승마라고 하여 해열제와 해독제로 사용한다.Horse riding (升麻, Cimicifugae Rhizoma ) is a perennial herb of the genus Buttercupaceae, and the root of the grass is called horse riding and used as antipyretic and antidote.

갈근(Puerariae radix)은 칡뿌리의 껍질로서 한방에서는 발한·해열·완하제(緩下劑)로서 고열·두통·고혈압·심부전·설사·어깨가 결릴 때 등에 처방한다. Puerariae radix is a shell of the root roots, which is prescribed for sweating, antipyretic and laxatives in Chinese medicine, when high fever, headache, hypertension, heart failure, diarrhea, and shoulders are formed.

녹차(Theae folium)는 동맥경화 예방 효과와 알코올과 담배해독 해소작용이 있으며, 기억력과 판단력 증진에도 도움이 되고, 식중독의 해독, 환경 호르몬 억제, 당뇨병, 다이어트, 콜레스테롤 억제 등의 효능이 알려져 있다.Green tea ( Theae folium ) has the effect of preventing atherosclerosis and alcohol and tobacco detoxification, memory and judgment, and is known for the detoxification of food poisoning, environmental hormone suppression, diabetes, diet, cholesterol suppression.

감초(Glycyrrhiza uralensis)는 한약재 뿐 아니라 제약회사, 식품 등 다양하게 많이 사용되고 있어 좋은 약에는 꼭 들어가는 중요한 재료인데, 해독 작용, 진경(鎭痙)작용, 거담 작용, 항염증·항알러지 작용, 위산분비억제작용 등이 알려져 있다.Licorice ( Glycyrrhiza uralensis ) is widely used in various medicines such as pharmaceutical companies and foods as well as herbal medicines, which is an important ingredient that is essential for good detoxification, antifungal action, expectorant action, anti-inflammatory and anti-allergic action, and gastric acid secretion. Inhibition and the like are known.

황기(Astragali radix)는 장미목 콩과의 여러해살이풀로 한방에서는 가을에 채취하여 노두(蘆頭)와 잔뿌리를 제거하고 햇빛에 말린 것을 황기라 하며, 강장·지한(止汗)·이뇨(利尿)·소종(消腫) 등의 효능이 있어 신체허약·피로권태·기혈허탈(氣血虛脫)·탈항(脫肛)·자궁탈·내장하수·식은땀·말초신경 등에 처방한다. Astragali radix is a perennial herb of rosacea legumes, which is harvested in the fall in Korea to remove outcrops and roots, and dried in sunlight. It has the effect of small bowel, and is prescribed for physical weakness, fatigue boredom, hemostasis deprivation, prolapse, uterine deprivation, internal sewage, cold sweat, and peripheral nerve.

황금(黃芩, Scutellaria baicalensis)은 통화식물목 꿀풀과의 여러해살이풀로, 한방에서는 뿌리를 해열·이뇨·지사·이담 및 소염제로 이용한다.Golden (黄 芩, Scutellaria baicalensis ) is a perennial plant of the moss family of the calliphytic plant.

산수유(Corini fructus)는 산수유 나무의 과육(果肉)으로, 자양강장·강정·수렴 등의 효능이 있어 현기증·월경과다·자궁출혈 등에 사용한다.Cornus ( Corini fructus ) is a flesh of the cornus tree, which is effective for nourishing tonic, gangjeong, and convergence, and is used for dizziness, excessive menstruation and uterine bleeding.

현초(Geranii herba)는 일명 이질풀이라고도 하며, 지사제로 사용되고, 부인병, 이질, 복통에 사용된다. Geranii herba (aka Geranii herba ), also known as dysentery, is used as a branch, and is used for women's diseases, dysentery and abdominal pain.

황련(黃連, Coptidis Rhizoma)은 11월경에, 재식 5∼6년 된 황련·왜황련의 뿌리를 채취하여 햇볕에 말린 것을 말하는데, 건위·진정·소염·항균 등의 효능이 있어 소화불량·위염·장염·복통·구토·이질·심계(心悸)·번열(煩熱)·정신불안·인후종통(咽喉腫痛)·토혈·코피·하혈·화상 등의 치료에 처방한다. Huang Yan ( Coptidis Rhizoma ) refers to the roots of 5-6 year old Hwang-yeon and Dwarf-Yang soybeans , dried in the sun.They have the effects of dry stomach, soothing, anti-inflammatory, anti-bacterial, indigestion, gastritis, It is prescribed for the treatment of enteritis, abdominal pain, vomiting, dysentery, heart system, heartburn, mental anxiety, sore throat, bleeding, nosebleeds, bleeding, and burns.

오미자(Schizandrae fructus)는 이판화군 미나리아재비목 목련과의 낙엽 덩굴식물로 한방에서 자양(滋養)·강장·진해(鎭咳)·거담(祛痰)·지한(止汗) 등의 효력이 있어 해수·유정(遺精)·구갈(口渴)·도한(盜汗)·급성간염 등에 처방한다. 민간에서는 오미자차를 만들어 마시며, 술도 담근다.Omija ( Schizandrae fructus ) is a deciduous vine plant of the genus Magnolia of Lipanaceae, which has the effects of nourishment, tonic, Jinhae, sputum, and cold winter in oriental medicine. Prescription for oil well, mouth, cold and acute hepatitis. In private, they make and drink Schisandra tea.

사간(Beiamcanda Chinensis)은 한방과 민간에서 소염, 진해, 편도선염, 진통, 폐렴, 해열, 각기 등에 대해 효험이 있다고 알려져 있다. Beiamcanda Chinensis is known for its effects on anti-inflammatory, antitussive, tonsillitis, analgesic, pneumonia, fever, and others in oriental medicine and in private.

두충(Eucommiae cortex)은 장미목 두충과의 낙엽활엽 교목으로, 한방에서는 나무껍질을 보약·강장제로 쓰고, 대뇌를 튼튼하게 하며, 폐와 무릎앓이·음습증을 다스린다. 민간에서는 잎을 달여서 신경통·고혈압에 쓰고 차로도 복용한다. Eucommiae cortex is a deciduous broad-leaved arboreous tree with rosewood larvae. In oriental medicine, the bark is used as a supplement and tonic, to strengthen the cerebrum, and to control lung and knee ailment and groin. In the private sector, the leaves are decocted and used for neuralgia and hypertension.

오배자(五倍子,Galla Rhois)는 매미목[同翅目] 진딧물과의 오배자면충이 옻나무과의 붉나무(오배자나무)의 잎에 기생하여 만든 벌레혹으로, 한방에서는 수렴(收斂)·지혈·해독·항균의 효력이 있어, 설사·탈항·위궤양·십이지장궤양·도한·유정(遺精)·혈변·혈뇨·구내염 등에 처방한다. 타닌 성분을 50∼60% 함유하고 있어 타닌제를 비롯하여 염모제(染毛劑)나 잉크의 원료로 사용하기도 한다. Galla Rhois is an insect worm that is formed by the larvae of the cicada aphids on the leaves of the Rhododendron of the Rhododendron, and in the oriental medicine, agglomerates, hemostasis, detoxification and antibacterial. It is effective and is prescribed for diarrhea, prolapse, gastric ulcer, duodenal ulcer, cold, oil well, bloody stool, hematuria and stomatitis. It contains 50 to 60% of tannins, which can be used as a raw material for hair dyes and inks, including tannins.

백굴채(Chelidonium majus L.)는 애기똥풀의 전초를 말린 것으로, 이 생약의 성분은 그람양성균, 결핵균, 진균에 대한 발육억제효과를 가지며, 진통제, 진해작용, 이뇨, 해독의 효과가 있고, 급성 및 만성 위염, 위궤양에도 사용된다. Chelidonium majus L. is dried dried celandine. Its constituents have inhibitory effects on gram-positive bacteria, Mycobacterium tuberculosis and fungi, and have analgesic, antitussive, diuretic and detoxification effects. It is also used for chronic gastritis and gastric ulcers.

고삼(苦蔘, Sophorae Radix)은 장미목 콩과의 여러해살이풀로 한방에서는 뿌리를 말린 것을 고삼이라 하는데, 맛이 쓰고 인삼의 효능이 있어 소화불량·신경통·간염·황달·치질 등에 처방한다. 민간에서는 줄기나 잎을 달여서 살충제로 사용하기도 한다.Ginseng (苦 蔘, Sophorae Radix ) is a perennial herb of rosacea legumes, and dried roots in oriental medicine are called ginseng. It is tasteless and has the effects of ginseng and is prescribed for indigestion, neuralgia, hepatitis, jaundice, and hemorrhoids. In the private sector, stems or leaves can be used as insecticides.

산사자(Crataegus pinnatifida)는 산사나무의 열매를 말린 것으로, 소화불량, 구토, 식체등에 유효하고, 부인의 산전산후의 병에도 유효하다. 산사자차의 경우 오래 마시면 기력이 좋아진다.Hawthorn ( Crataegus pinnatifida ) is a dried fruit of the hawthorn, which is effective for indigestion, vomiting, and planting. Sansazacha is a good drink for a long time.

본 발명에서는 상기한 효능을 갖는 생약재들이 항산화 효과를 가지면서 동시에 장내 유용 세균의 성장을 증식시킬 수 있다는 것을 발견하고, 이를 목적으로 하는 기능성 조성물로 조성한 것이다.In the present invention, it is found that the herbal medicines having the above-mentioned efficacy can have the antioxidant effect and at the same time can proliferate the growth of useful intestinal bacteria, and have been formulated with a functional composition for this purpose.

이하, 실시예를 들어 본 발명을 상세히 설명하지만 본 발명이 이들 예로만 한정되는 것은 아니다. Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited only to these examples.

<실시예 1> 항산화효과를 갖는 천연산물의 선별Example 1 Selection of Natural Products Having Antioxidant Effect

항산화력을 가지는 천연산물의 선별은 도 1에서 보는 바와 같이 용존산소 분석법(D.O. analysed method)을 사용하였다. 용존산소 분석법에 의한 항산화력의 측정은 리놀레산(Linoleic acid) 1g에 Tween40 용액 2㎖를 넣고, 여기에 각 천연산물의 열수추출물 3㎖를 첨가하고 증류수로 최종량을 30㎖로 한 후, 37℃의 항온조에서 Fe2+ 이온을 첨가하여 용존산소(D.O.)의 감소를 측정하고, 얻은 감소곡선의 아래쪽 면적(AUC; Area Under Curve)을 계산하여 항산화력을 구하였다. 항산화력의 정도를 대조군과 비교하여, 베타 카로틴보다 항산화력이 강하거나 유사한 생약재를 선별하고, 이를 하기 표 1에 나타내었다.The selection of natural products having antioxidant power was performed using a DO analysed method as shown in FIG. To measure the antioxidant power by dissolved oxygen analysis, 2 ml of Tween40 solution was added to 1 g of linoleic acid, 3 ml of hot water extract of each natural product was added, and the final amount was 30 ml with distilled water. The reduction of dissolved oxygen (DO) was measured by the addition of Fe 2+ ions in a thermostatic chamber, and the antioxidant power was calculated by calculating the area under curve (AUC). Compared with the control group, the degree of antioxidant power was selected from herbal drugs with stronger or similar antioxidant power than beta carotene, and are shown in Table 1 below.

상기 표 1로부터, 상기 생약재들 중 특히 승마, 산수유, 현초, 백작약, 천문동, 음양곽, 상백피, 연자육, 백굴채, 황련, 백출, 진피, 오배자, 두충, 황백, 계피, 구기자, 녹차, 오가피, 사간, 고삼, 당귀, 괴화, 석창포, 갈근, 황기 및 오미자는 종래 항산화제로 사용되고 있는 베타카로틴보다 항산화 효과가 우수하거나 유사한 정도의 항산화 효과를 나타내므로, 항산화제로서 유용하게 사용될 수 있음을 알 수 있다. From Table 1, among the herbs, in particular horse riding, cornus, Hyuncho, Baekjak, Astronomical dong, Yin Yang Kwak, Sangbaekpi, lotus root, Baekchulchae, Hwangnyeon, Baekchul, Dermis, Gallja, Tofu, Hwangbaek, Cinnamon, Gugija, green tea, Ogapi, Sagan , Ginseng, Angelica, chrysanthemum, Seokchangpo, brown root, Astragalus and Schisandra chinensis, beta-carotene is used as an antioxidant, because it shows an excellent antioxidant effect or a similar degree of antioxidant effect, it can be seen that it can be usefully used as an antioxidant.

<실시예 2> 장내 유용세균의 성장 촉진 효과 시험Example 2 Growth Promoting Effect Test of Intestinal Useful Bacteria

상기 실시예 1에서 선별된 항산화 효과를 생약재들이 장내 유용 세균의 성장을 촉진하는지에 대해 락토바실러스 아시도필러스 (Lactobacillus acidophilus), 락토바실러스 플란타룸(Lactobacillus plantarum) 비피도박테룸 아도레스센티스 (Bifidobacterum adolescentis), 비피도박테룸 비피덤 (Bifidobacterum bifidum), 비피도박테룸 인판티스 (Bifidobacterum infantis), 클로스티리디움 부티리컴 (Clostridium butyricum)을 시험세균으로 사용하여 시험하였다. 시험균주는 각 세균의 특성에 맞는 배지에서 전배양하였다. 즉, 락토바실러스 아시도필러스(Lactobacillus acidophilus)와 락토바실러스 플란타룸(Lactobacillus plantarum)은 MRS(DE MAN, ROGOSA, SHARPE)배지를, 비피도박테룸 아도레스센티스(Bifidobacterum adolescentis), 비피도박테룸 비피덤(Bifidobacterum bifidum) 및 비피도박테룸 인판티스(Bifidobacterum infantis)는 비피도박테리움(Bifidobacterium)배지를, 클로스티리디움 부티리컴 (Clostridium butyricum)은 CAB(Clostridium acetobutylcum)배지를 사용하였다.시험 플라스크에 천연산물의 열수추출물을 첨가한 배지 100㎖를 넣고, 전배양한 균주를 배지 총량의 0.1%의 농도(0.3㎖)로 접종한 후 37℃에서 배양하면서 6시간 간격으로 시료를 채취하였다. 채취한 시료에 대해 분광광도계(spectrophotometer)를 사용하여 660nm에서 흡광도를 측정하여 시간에 따른 균주의 성장정도를 비교하였다. 이때, 천연산물을 전혀 넣지 않은 대조군에서의 측정은 배양액을 블랭크(공시험)로 사용하였고, 천연산물을 넣은 시료군에서의 측정은 천연산물을 넣은 배양액을 블랭크로 사용하였다. Lactobacillus acidophilus ( Lactobacillus acidophilus), Lactobacillus plantarum (Bactidocillus plantarum) Bifidobacterum adoressentis (Bifidobacterum ) on the antioxidant effects selected in Example 1 to promote the growth of useful intestinal bacteria adolescentis, Bifidobacterum bifidum, Bifidobacterum infantis, and Clostridium butyricum were tested as test bacteria. Test strains were pre-cultured in a medium suitable for the characteristics of each bacteria. That is, Lactobacillus acidophilus and Lactobacillus plantarum are MRS (DE MAN, ROGOSA, SHARPE) medium, Bifidobacterum adolescentis , Bifidobacterum Bifi Bifidobacterum bifidum and Bifidobacterum infantis used Bifidobacterium medium and Clostridium butyricum used Clostridium acetobutylcum (CAB) medium in test flasks. 100 ml of the medium to which the hot water extract of the product was added, and the precultured strains were inoculated at a concentration of 0.1% (0.3 ml) of the total amount of the culture medium, and the samples were collected at intervals of 6 hours while incubating at 37 ° C. The collected samples were measured for absorbance at 660 nm using a spectrophotometer to compare the growth of the strains over time. At this time, the measurement in the control group without any natural product was used as a blank (blank test), and the measurement in the sample group containing the natural product was used as a blank culture medium containing the natural product.

2-1. 락토바실러스 아시도필러스에 대한 성장 촉진 시험2-1. Growth promotion test for Lactobacillus asidophilus

하기에서와 같이 1종의 생약재, 2종의 생약재, 3종의 생약재 및 4종의 생약재의 조합을 1종의 생약재의 첨가량은 배지 총량의 3%, 2종의 생약제 첨가량은 배지 총량의 6%, 3종의 생약제 첨가량은 배지 총량의 9% 및 4종의 생약제 첨가량은 배지 총량의 12%, 즉, 천연산물 1종류에 대하여 3%의 양으로 사용하였으며, 락토바실러스 아시도필러스 균주는 배지총량의 0.1%의 농도로 접종한 후, 37℃에서 6 시간 간격으로 시료를 채취하여 시간에 따른 균주의 성장정도는 분광광도계를 사용하여 660 nm에서 흡광도를 측정하여 천연산물을 전혀 넣지 않고 실험한 것을 대조군으로하여 그 성장의 정도를 비교하였다. Combination of one herbal medicine, two herbal medicines, three herbal medicines and four herbal medicines, as shown below, the amount of one herbal medicine added 3% of the total amount of the medium, the two herbal medicines added 6% of the total medium The amount of the three herbal drugs added was 9% of the total amount of the medium and the four herbal drugs added were 12% of the total amount of the medium, that is, 3% of one natural product, and the Lactobacillus asidophilus strain was used as the medium. After inoculation at a concentration of 0.1% of the total amount, samples were taken at 37 ° C. at 6 hour intervals, and the growth rate of the strains was measured at 660 nm using a spectrophotometer. As a control, the degree of growth was compared.

(2-1-1) 1종의 생약재(2-1-1) One type of herbal medicine

백작약, 백출, 음양곽, 석창포, 진피, 당귀, 오가피, 구기자, 계피, 괴화, 황백, 연자육, 천문동, 상백피Baekjak, Baekchul, Eumyanggok, Seokchangpo, Dermis, Angelica, Ogapi, Wolfberry, Cinnamon, Minhwa, Yellow white, Yeonjak, Astronomical dong, Sangbaekpi

(2-1-2) 2종의 생약재(2-1-2) Two kinds of herbal medicine

석창포+계피, 석창포+괴화, 석창포+황기, 석창포+승마, 진피+갈근, 진피+계피, 진피+녹차, 갈근+계피Sukchangpo + cinnamon, Sukchangpo + lump, Sukchangpo + Astragalus, Sukchangpo + horseriding, dermis + brown root, dermis + cinnamon, dermis + green tea, brown root + cinnamon

(2-1-3) 3종의 생약재(2-1-3) Three kinds of herbal medicine

승마+계피+녹차, 승마+계피+감초, 승마+황기+진피, 승마+진피+녹차, 승마+계피+황금, 승마+석창포+진피Horse riding + cinnamon + green tea, horse riding + cinnamon + licorice, horse riding + astragalus + dermis, horse riding + dermis + green tea, horse riding + cinnamon + golden, horse riding + stone spear + dermis

(2-1-4) 4종의 생약재(2-1-4) Four kinds of herbal medicine

감초+녹차+황금+계피, 승마+감초+황금+계피, 승마+감초+석창포+녹차, 감초+황금+진피+계피Licorice + Green Tea + Golden + Cinnamon, Horse Riding + Licorice + Golden + Cinnamon, Horse Riding + Licorice + Stone Spear + Green Tea, Licorice + Golden + Dermis + Cinnamon

그 결과를 도2a 내지 도 2j에 나타내었다.The results are shown in Figs. 2A to 2J.

2-2. 락토바실러스 플란타룸에 대한 성장 촉진 시험2-2. Growth promotion test for Lactobacillus plantarum

상기 2-1에서와 동일한 방법으로 하기 생약재의 락토바실러스 플란타룸에 대한 성장 촉진 효과를 시험하였다.In the same manner as in the above 2-1, the growth promoting effect of the following herbal medicine was tested for Lactobacillus plantarum.

(2-2-1) 1종의 생약재(2-2-1) One kind of herbal medicine

황백, 연자육, 천문동, 상백피, 오가피, 구기자, 계피, 괴화, 승마, 산수유, 녹차, 두충, 오배자, 고삼, 현초Hwangbaek, Yeonjak, Astronomical dong, Sangbaekpi, Ogapi, Gojija, Cinnamon, Gohhwa, Horse riding, Cornus, Green tea, Tofu, Mungja, Gosam, Hyuncho

(2-2-2) 2종의 생약재(2-2-2) Two kinds of herbal medicine

백작약+산수유, 백작약+음양곽, 백작약+황련, 백작약+오미자, 오미자+감초, 오미자+녹차, 감초+녹차, 황련+오미자, 황련+감초, 황련+녹차, 현초+오미자, 현초+감초, 현초+녹차Baekjak + Cornus + Baekjak + Eumyangkku, Baekjak + Hwangnyeon, Baekjak + Schisandra + Schisandra + Licorice, Schisandra + Green Tea, Licorice + Green Tea, Sakura + Schisandra + Sakura + Licorice, Sakura + Sakura + Hyeonja + Schisandra, Hyuncho + Licorice, Hyuncho + green tea

(2-2-3) 3종의 생약재(2-2-3) Three kinds of herbal medicine

산수유+녹차+황련, 산수유+녹차+오미자, 산수유+녹차+백출, 산수유+녹차+백작약, 산수유+녹차+현초, 산수유+녹차+황금, 산수유+황련+오미자, 산수유+황련+백출, 산수유+황련+백작약, 산수유+황련+현초, 산수유+황련+황금, 산수유+오미자+백출, 산수유+오미자+백작약, 산수유+오미자+현초, 산수유+백출+백작약Cornus + Green Tea + Huangshan, Cornus + Green Tea + Schisandra, Cornus + Green Tea + White Tea, Cornus + Green Tea + White Peony, Cornus + Green Tea + Hyuncho, Cornus + Green Tea + Golden, Cornus + Sulfur + Schisandra + Cornus + Sulfur + White Rice, Cornus + Huangshan + White Peony, Cornus + Hundred + Hyuncho, Cornus + Hundred + Golden, Cornus + Schisandra + White Extract, Cornus + Schisandra + White Peony, Cornus + Schisandra + Hyeoncho, Cornus + White Peony

(2-2-4) 4종의 생약재(2-2-4) Four kinds of herbal medicine

산수유+녹차+황련+백작약, 산수유+녹차+황련+오미자, 산수유+녹차+황련+백출, 산수유+황련+백작약+오미자, 산수유+녹차+백작약+황금, 산수유+녹차+황련+황금, 녹차+오미자+황련+백작약, 산수유+녹차+황련+현초, 산수유+오미자+백작약+녹차, 산수유+오미자+백작약+백출, 산수유+녹차+백작약+백출, 산수유+황련+백작약+황금, 산수유+백작약+현초+녹차, 산수유+백작약+현초+황련, 산수유+백작약+현초+오미자Cornus + Green Tea + Rhubarb + White Peony, Cornus + Green Tea + Rhubarb + Schisandra + Cornus + Green Tea + Rhubarb + White Rice, Cornus + Green Tea + White Pea + Schisandra, Cornus + Green Tea + White Pea + Golden, Cornus + Green Tea + Huang Zhu + Golden, Green Tea + Schizandra chinensis + White Peony, Cornus + Green Tea + Sulfur + Hyunju, Cornus + Schizandra + White Peony + Green Tea, Cornus + Schizandra + White Peony + White Extract, Cornus + Green Tea + White Peony + White Extract, Cornus + Sulfur + White Peony + Golden, Cornus + White Peony + Golden Hyuncho + Green Tea, Cornus + White Peony + Hyuncho + Huang Yan, Cornus + Peony + Hyuncho + Schisandra

그 결과를 도 3a 내지 도 3o에 나타내었다. The results are shown in Figures 3a to 3o.

2-3. 비피도박테룸 아도레스센티스의 성장 촉진 시험2-3. Growth Promotion Test of Bifidobacterum adorescentis

상기 2-1에서와 동일한 방법으로 하기 생약재의 비피도박테륨 아도레스센티스에 대한 성장 촉진 효과를 시험하였다.In the same manner as in 2-1, the growth promoting effect of Bifidobacterium adorescentis was tested.

(2-3-1) 1종의 생약재(2-3-1) One kind of herbal medicine

오가피, 구기자, 계피, 괴화, 황백, 연자육, 천문동, 상백피, 진피, 갈근, 당귀, 황금Ogapi, wolfberry, cinnamon, chunks, yellow white, lotus root, astronomical dong, baekbaekpi, dermis, brown root, donkey

(2-3-2) 2종의 생약재(2-3-2) Two herbal medicines

백작약+황백, 백작약+상백피, 백작약+녹차, 백작약+황기, 백출+사간, 음양곽+당귀, 음약곽+괴화, 음양곽+황백, 백작약+백출, 백작약+음양곽, 백작약+당귀, 백작약+괴화, 백작약+사간, 백출+음양곽, 백출+당귀, 백출+괴화Baekjak + Yangbaek, Baekak + baekbaekpi, Baekjak + Green tea, Baekjak + Yanggi, Baekchul + Sanjang, Yin Yang Kwak, Donkak, Yin Yangkwa, Yin Yang Kwak, Yebaekbaek, Baekyak + Bukchul, Baekak + Yeung Kwak, Baekjak + Dangwook, Baekhwa + Baekhwa, Baekjak + Shrine, baekchul + eumgyuk, baekchul + donkey, baekchul + lump

(2-3-3) 3종의 생약재(2-3-3) Three herbal medicines

녹차+사간+당귀, 녹차+사간+황기, 녹차+사간+상백피, 녹차+사간+백작약, 녹차+사간+과화, 녹차+사간+음양곽, 녹차+당귀+황기, 녹차+당귀+상백피, 녹차+상백피+백작약, 녹차+상백피+괴화, 녹차+황기+상백피, 녹차+백작약+음양곽, 사간+당귀+황기, 사간+당귀+상백피, 사간+당귀+백작약, 사간+당귀+괴화 Green tea + sagan + donkey, green tea + sagan + wanggi, green tea + sagan + baekbaekpi, green tea + sagan + white peony, green tea + sagan + hwahwa, green tea + sagan + yin seok, green tea + donkey + hwanggi, green tea + donkey + sangbaekpi, green tea + Sangbaekpi + Baekje, Green Tea + Baekbaek + Mihwa, Green Tea + Astragalus + Sangbaekpi, Green Tea + Baekak + Yin-Yang Kwak, Sagan + Donkey + Astragalus, Sagan + Donkey + Saekbaekpi, Sagan + Donkey + Baekjak, Sagan + Donkey + Kahwa

(2-3-4) 4종의 생약재(2-3-4) Four kinds of herbal medicine

사간+당귀+음양곽+백작약, 사간+당귀+음양곽+괴화, 사간+당귀+음양곽+녹차, 사간+당귀+음양곽+황기, 사간+당귀+음양곽+상백피, 당귀+음양곽+백작약+괴화, 당귀+음양곽+백작약+녹차, 당귀+음양곽+백작약+황기, 당귀+음양곽+백작약+상백피, 음양곽+백작약+괴화+녹차, 음양곽+백작약+괴화+황기, 음양곽+백작약+괴화+상백피, 백작약+괴화+녹차+황기, 백작약+괴화+녹차+상백피, 괴화+녹차+황기+상백피Sagan + Dangi + Eumseong + Baekak, Sagan + Dangui + Eumseong-kwa + Gaehwa, Sagan + Dangui + Eumseongkung + Green tea, Sagan + Dangong + Eumseongkung + Sanggi, Sagan + Dangong + Eumseongk + Sangbaekpi, Dangdong + Eumseong + Baekhwa + Gwahwa, Donkey + Eum Yang Kwak + Peony + Green Tea, Dongguk + Eum Yang Kwa + Baek Pak + Astragalus, Dangui + Eum Yang Kwak + Paek Pak + Sangbaekpi, Eum Yang Kwak + Paek Pak + Begong + Green Tea, Eum Yang Kwak + Paek Pak + Begong + Astragalus Green tea + Astragalus, Earl of pill + Black tea + Green tea + White tea, Black tea + Green tea + Yellow tea + White tea

그 결과를 도 4a 내지 도 4o에 나타내었다. The results are shown in Figures 4a to 4o.

2-4. 비피도박테룸 비피덤의 성장 촉진 시험2-4. Growth Promotion Test of Bifidobacterum Bifidem

상기 2-1에서와 동일한 방법으로 하기 생약재의 비피도박테룸 비피덤에 대한 성장 촉진 효과를 시험하였다.In the same manner as in the above 2-1, the growth promoting effect of Bifidobacterum Bifidum of the following herbal medicine was tested.

(2-4-1) 1종의 생약재(2-4-1) One kind of herbal medicine

연자육, 산수유, 사간Lotus root, cornus, liver

(2-4-2) 2종의 생약재(2-4-2) Two kinds of herbal medicine

연자육+산수유, 연자육+사간, 연자육+녹차Yeonjagi + Masugi, Yeonjagi + Began, Yeonjagi + Green Tea

(2-4-3) 3종의 생약재(2-4-3) Three kinds of herbal medicine

연자육+산수유+녹차, 연자육+산수유+사간, 연자육+녹차+사간, 산수유+녹차+사간Yeonjagi + Cornus + Green Tea, Yeonjagi + Masuyu + Samgan, Yeonjagi + Green Tea + Sagan, Cornus + Green Tea + Sagan

(2-4-4) 4종의 생약재(2-4-4) Four kinds of herbal medicine

연자육+녹차+사간+산수유, 연자육+녹차+사간+감초, 녹차+사간+산수유+감초, 연자육+사간+산수유+감초, 연자육+녹차+산수유+감초Yeondied meat + green tea + sweet and sour milk, soft citrus fruit + green tea + sweet corn + licorice, green tea + sweet liver + cornus + licorice

그 결과를 도 5a 내지 5e에 나타내었다.The results are shown in Figures 5a to 5e.

2-5. 비피도박테룸 인판티스의 성장 촉진 시험2-5. Growth Acceleration Test of Bifidobacterum Infantis

상기 2-1에서와 동일한 방법으로 하기 생약재의 비피도박테룸 인판티스에 대한 성장 촉진 효과를 시험하였다.In the same manner as in the above 2-1, the growth promoting effect of Bifidobacterum infantis was tested.

(2-5-1) 1종의 생약재(2-5-1) One kind of herbal medicine

진피, 오가피, 승마, 산수유, 녹차, 두충, 오배자, 현초, 백굴채, 황기Dermis, Ogapi, Horseback Riding, Cornus, Green Tea, Tofu, Mungja, Hyuncho, Baekgulchae, Astragalus

(2-5-2) 2종의 생약재(2-5-2) Two kinds of herbal medicine

음양곽+녹차, 음양곽+산사자, 음양곽+두충Eum Yang Kwa + Green Tea, Eum Yang Kwa + Mountain Lion, Eum Yang Kwa + Duchung

(2-5-3) 3종의 생약재(2-5-3) Three kinds of herbal medicine

녹차+음양곽+백굴채, 녹차+음양곽+진피, 녹차+음양곽+갈근, 녹차+음양곽+황기, 녹차+백굴채+진피, 녹차+백굴채+황기, 녹차+진피+갈근, 녹차+진피+황기, 녹차+갈근+황기, 음양곽+백굴채+진피, 음양곽+백굴채+갈근, 음양곽+백굴채+황기, 음양곽+진피+갈근, 음양곽+진피+황기, 음양곽+갈근+황기, 백굴채+진피+갈근Green tea + Yin-Yang Kwak-chae, green tea + Yin-Yeum + Dermis, green tea + Yin-Yang Kwak, green tea + Yin-Yang Kwak + Astragalus , Green tea + brown root + Astragalus + Eumyangquak + Baekgulchae + dermis, Eumyangquak + Baekgulchae + brown root, Yinyangquat + Baekgulchae + Astragalus, Eumyangquak + dermis + Brown root, Eumyangquak + dermis + Astragalus + Brown

(2-5-4) 4종의 생약재(2-5-4) Four kinds of herbal medicine

녹차+백굴채+황기+음양곽, 녹차+백굴채+황기+진피, 녹차+백굴채+황기+갈근, 백굴채+황기+음양곽+진피, 백굴채+황기+음양곽+갈근, 황기+음양곽+갈근+진피, 녹차+황기+음양곽+갈근, 녹차+음양곽+진피+갈근, 녹차+백굴채+음양곽+진피, 녹차+백굴채+음양곽+갈근, 녹차+백출채+진피+갈근, 녹차+황기+음양곽+진피, 녹차+황기+진피+갈근, 백굴채+음양곽+진피+갈근Green tea + Baekgulchae + Astragalus + Eumseong, Green tea + Baekmulchae + Astragalus + Dermis, Green tea + Baekmulchae + Astragalus + Dermis, Baekchulchae + Astragalus + Yinseong + Dermis + Dermis, Green Tea + Astragalus + Eumseonggok + Green Tea, Green Tea + Eumseonggok + Dermis + Brown Root, Green Tea + Baekgokchae + Eumseonggok + Dermis Eum Yang Kwak + Dermis, Green Tea + Astragalus + Dermis + Brown Root, Baekgulchae + Eum Yang Kwak + Dermis + Brown Root

그 결과를 도 6a 내지 도 6l에 나타내었다. The results are shown in FIGS. 6A-6L.

2-6. 클로스티리디움 부티리컴의 성장 촉진 시험2-6. Growth Promotion Test of Clostridium Butyrim

상기 2-1에서와 동일한 방법으로 하기 생약재의 클로스티리디움 부티리컴에 대한 성장 촉진 효과를 시험하였다.In the same manner as in the above 2-1, the growth promoting effect of the following herbal medicine was tested for Closthyridium butyricum.

(2-6-1) 1종의 생약재(2-6-1) One kind of herbal medicine

구기자, 괴화, 백굴채, 백작약, 백출, 음양곽, 석창포, 진피, 당귀, 황금, 오가피Wolfberry, Gochuhwa, Baekgulchae, Count, Baekchul, Yin Yang Kwak, Seokchangpo, Dermis, Angelica, Golden, Ogapi

(2-6-2) 2종의 생약재(2-6-2) Two kinds of herbal medicine

백작약+음양곽, 백작약+진피, 백작약+갈근, 백작약+당귀, 백작약+황금, 백작약+괴화, 백작약+연자육, 백작약+상백피, 백작약+녹차, 음양곽+진피, 음양곽+갈근, 음양곽+당귀, 음양곽+황금, 음양곽+괴화, 음양곽+연자육, 음양곽+상백피Earl of Peony + Yin-Yang, Earl of Peony + Dermis, Earl of Peony + Brown Root, Earl of Peony, Earl of Peony + Golden, Earl of Peony + Greek, Earl of Peony + Yeonjak, Earl of Peony + Eyebaekpi, Earl of Peony + Green Tea, Yin-Yang-Kwa + Dermis, Yin-Yang-Gak-Geun, Yin-Yang-Gang + Dang-Gi, Yin-Kyo + Golden, Yin Yang Kwak, Minhwa, Yin Yang Kwak + Yeon-yuk, Yin Yang Kwak + Sangbaekpi

(2-6-3) 3종의 생약재(2-6-3) Three kinds of herbal medicine

음양곽+갈근+괴화, 음양곽+갈근+백작약, 음양곽+갈근+당귀, 음양곽+갈근+연자육, 음양곽+갈근+황금, 음양곽+갈근+녹차, 음양곽+괴화+백작약, 음양곽+괴화+당귀, 음양곽+괴화+연자육, 음양곽+괴화+황금, 음양곽+괴화+녹차, 음양곽+백작약+당귀, 음양곽+백작약+연자육, 음양곽+백작약+황금, 음양곽+백작약+녹차, 음양곽+당귀+연자육Yin-Yang + Geun-Geun + Ingots, Yin-Yang-Gang + Geun-Geun + Peark, Eum-Yang-Gang + Dung-Gi, Dang-Yang-Gang + Geun-Geun-Yang, Yin-Yang-Gang + Green Tea, Yin-Yang-Gang Goehwa + Yeonjak, Yinyanggok + Gohwa + Golden, Yinyanggok + Gohwa + Green Tea, Yinyanggok + Baekjak + Donkey, Yinyanggok + Baekyak + Yeonjak, Yinyangkok + Baekjak + Golden, Yinyangkok + Baekjak + Green Tea

(2-6-4) 4종의 생약재(2-6-4) Four kinds of herbal medicine

음양곽+갈근+연자육+백작약, 음양곽+갈근+연자육+녹차, 음양곽+갈근+연자육+괴화, 음양곽+갈근+연자육+당귀, 갈근+연자육+백작약+녹차, 갈근+연자육+백작약+괴화, 갈근+연자육+백작약+당귀, 연자육+백작약+녹차+괴화, 연자육+백작약+녹차+당귀, 연자육+백작약+괴화+당귀, 백작약+녹차+괴화+당귀, 갈근+연자육+녹차+당귀, 음양곽+갈근+백작약+녹차, 갈근+백작약+괴화+당귀, 음양곽+연자육+백작약+당귀Eum Yang Kwak + lotus root + Baek Pak, Eum Yang Kwak + brown root + lotus root + green tea, Eum Yang Kwak + brown root + lotus root + black tea, Eum Yang Kwak + brown root + lotus root + donkey, brown root + lotus root + white peony + green tea, brown root + lotus root + white peony + green tea, white root + Yeonjak + Baekjak + Donggu, Yeonjak + Baekak + Green Tea + Mind, Yeonjak + Baekak + Green Tea + Donkey, Yeonjak + Baekja + Black Tea + Donkey, Baekja + Green Tea + Black Tea + Donkey, Black Root + Yeonjak + Green Tea + Donkey, Yin Yang + Brown Root + Earl of Peony + Green Tea, Brown Root + Earl of Peony + Gohwa + Donkey

그 결과를 도 7a 내지 도 7o에 나타내었다. The results are shown in Figures 7a to 7o.

상기 결과들로부터, 백작약, 백출, 음양곽, 석창포, 진피, 당귀, 오가피, 구기자, 계피, 괴화, 황백, 연자육, 천문동, 상백피, 승마, 갈근, 녹차, 감초, 황기, 황금, 산수유, 현초, 황련, 오미자, 사간, 두충, 오배자, 백굴채, 고삼 및 산사자로 이루어진 군에서 선택된 1종 이상은 장내 유용 세균에 대한 성장촉진 효과가 있음을 알 수 있다. From the above results, Baekjak, Baekchul, Yin-Yang, Sukchangpo, Dermis, Angelica, Ogapi, Wolfberry, Cinnamon, Gochujang, Yellow white, lotus root, Astronomical dong, Sangbaekpi, Horse riding, Brown root, Green tea, Licorice, Astragalus, Golden, Cornus, Hyeoncho, Hwangyeon At least one selected from the group consisting of Schisandra chinensis, Schisandra chinensis, Tobacco, Schisandra chinensis, Baekchulchae, Red ginseng, and mountain lion can be seen that there is a growth promoting effect on the intestinal useful bacteria.

본 발명의 조성물을 사용하면 이 조성물의 항산화효과에 의해 생체내에서 자유 라디칼을 제거할 수 있어 노화, 결장암, 치매 등의 자유 라디칼에 의해 유발되는 질병을 예방하는 효과가 있다. 또한, 장내 유용 세균의 증식 효과에 의해 장내 감염에 대한 면역성 증진, 설사성 질환의 예방, 결장암(colon cancer) 예방, 고콜레스테롤 혈증(hypercholestero-laemia; 혈액중에 콜레스테롤이 과잉으로 존재하는 상태) 예방, 유당(lactose)의 이용성 개선, 상부 위장관(upper gastrointestinal tract) 질병의 예방, 장점막벽(gut mucosal barrier)의 안정화 등을 이룰 수 있다.When the composition of the present invention is used, free radicals can be removed in vivo by the antioxidant effect of the composition, thereby preventing diseases caused by free radicals such as aging, colon cancer, and dementia. In addition, due to the proliferative effect of intestinal useful bacteria, it is possible to enhance immunity against intestinal infections, to prevent diarrheal diseases, to prevent colon cancer, to prevent hypercholestero-laemia (a condition in which excess cholesterol is present in the blood), Improved lactose availability, prevention of upper gastrointestinal tract disease, stabilization of gut mucosal barriers, and the like.

또한, 이 기능성 조성물은 천연물인 생약재로 이루어졌기 때문에, 경제적 부담이 적고, 간편하게 투여될 수 있다. In addition, since the functional composition is made of natural herbal medicines, the functional burden is low and can be easily administered.

도 1은 용존산소 분석법으로 항산화 효과를 측정하는 방법을 나타내는 도면이다. 1 is a view showing a method for measuring the antioxidant effect by dissolved oxygen analysis.

도 2a 내지 도 2j는 본 발명의 조성물에 의한 시간의 경과에 따른 락토바실러스 아시도필러스 (Lactobacillus acidophilus)의 성장률을 나타내는 그래프들이다.2a to 2j are graphs showing the growth rate of Lactobacillus acidophilus over time by the composition of the present invention.

도 3a 내지 도 3p은 본 발명의 조성물에 의한 시간의 경과에 따른 락토바실러스 플란타룸(Lactobacillus plantarum)의 성장률을 나타내는 그래프들이다.3a to 3p are graphs showing the growth rate of Lactobacillus plantarum over time by the composition of the present invention.

도 4a 내지 도 4o는 본 발명의 조성물에 의한 시간의 경과에 따른 비피도박테룸 아도레스센티스 (Bifidobacterum adolescentis)의 성장률을 나타내는 그래프들이다.4A to 4O are graphs showing the growth rate of Bifidobacterum adolescentis over time by the composition of the present invention.

도 5a 내지 도 5e는 본 발명의 조성물에 의한 시간의 경과에 따른 비피도박테룸 비피덤 (Bifidobacterum bifidum)의 성장률을 나타내는 그래프들이다.5a to 5e are Graphs showing the growth rate of Bifidobacterum bifidum over time by the composition of the present invention.

도 6a 내지 도 6l은 본 발명의 조성물에 의한 시간의 경과에 따른 비피도박테룸 인판티스 (Bifidobacterum infantis)의 성장률을 나타내는 그래프들이다.6a to 6l are Graphs showing the growth rate of Bifidobacterum infantis over time by the composition of the present invention.

도 7a 내지 도 7o는 본 발명의 조성물에 의한 시간의 경과에 따른 클로스티리디움 부티리컴 (Clostridium butyricum)의 성장률을 나타내는 그래프들이다.Figures 7a-7o by the composition of the present invention These graphs show the growth rate of Clostridium butyricum over time.

Claims (8)

(A) 백작약, 백출, 음양곽, 석창포, 진피, 당귀, 오가피, 구기자, 계피, 괴화, 황백, 연자육, 천문동, 상백피 및 승마로 이루어진 군에서 선택된 1종 이상; 및 (A) at least one member selected from the group consisting of Baekjak, Baekchul, Eumyanggok, Seokchangpo, Dermis, Angelica, Ogapi, Wolfberry, Cinnamon, Gochu, Yellow white, Yeonjak, Astronomical dong, Sangbaekpi and Horseback riding; And (B) 갈근, 녹차, 감초, 황기, 황금, 산수유, 현초, 황련, 오미자, 사간, 두충, 오배자, 백굴채, 고삼 및 산사자로 이루어진 군에서 선택된 1종 이상; (B) at least one member selected from the group consisting of brown root, green tea, licorice, astragalus, golden, cornus, hyacinth, rhubarb, schisandra chinensis, sagan, tofu, locust, baekgulchae, gosam and hawthorn; 을 함유하는 것을 특징으로 하여 항산화성을 갖는, 장내 세균 성장 촉진용 조성물.A composition for promoting intestinal bacterial growth, characterized by containing an antioxidant. 제 1항에 있어서, 상기 장내 세균은 락토바실러스 아시도필러스 (Lactobacillus acidophilus), 락토바실러스 플란타룸 (Lactobacillus plantarum), 비피도박테룸 아도레스센티스 (Bifidobacterum adolescentis), 비피도박테룸 비피덤 (Bifidobacterum bifidum), 비피도박테룸 인판티스 (Bifidobacterum infantis) 또는 클로스티리디움 부티리컴 (Clostridium butyricum)인 것을 특징으로 하는 조성물.According to claim 1, wherein the intestinal bacteria are Lactobacillus acidophilus , Lactobacillus plantarum , Bifidobacterum adolescentis , Bifidobacterum bifidum ), Bifidobacterum infantis or Clostridium butyricum . 삭제delete 삭제delete 삭제delete 삭제delete 삭제delete 제 1항 또는 제 2항에 있어서, 상기 조성물은 차, 음료 또는 식품의 제형을 갖는 것을 특징으로 하는 조성물.The composition of claim 1 or 2, wherein the composition has a formulation of tea, beverage or food.
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