KR100474202B1 - 티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체 - Google Patents

티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체 Download PDF

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Publication number
KR100474202B1
KR100474202B1 KR10-2002-0024595A KR20020024595A KR100474202B1 KR 100474202 B1 KR100474202 B1 KR 100474202B1 KR 20020024595 A KR20020024595 A KR 20020024595A KR 100474202 B1 KR100474202 B1 KR 100474202B1
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KR
South Korea
Prior art keywords
methyl
group
compound
reaction
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR10-2002-0024595A
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English (en)
Korean (ko)
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KR20030086373A (ko
Inventor
강헌중
함정엽
Original Assignee
강헌중
함정엽
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Publication date
Priority to KR10-2002-0024595A priority Critical patent/KR100474202B1/ko
Application filed by 강헌중, 함정엽 filed Critical 강헌중
Priority to US10/513,408 priority patent/US7241901B2/en
Priority to EP03721130A priority patent/EP1501811B1/en
Priority to PCT/KR2003/000877 priority patent/WO2003106442A1/en
Priority to ES03721130T priority patent/ES2330095T3/es
Priority to DE60328376T priority patent/DE60328376D1/de
Priority to JP2004513274A priority patent/JP2005536480A/ja
Priority to CNB038100819A priority patent/CN100457744C/zh
Publication of KR20030086373A publication Critical patent/KR20030086373A/ko
Application granted granted Critical
Publication of KR100474202B1 publication Critical patent/KR100474202B1/ko
Priority to US11/730,658 priority patent/US20070179300A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
KR10-2002-0024595A 2002-05-04 2002-05-04 티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체 Expired - Fee Related KR100474202B1 (ko)

Priority Applications (9)

Application Number Priority Date Filing Date Title
KR10-2002-0024595A KR100474202B1 (ko) 2002-05-04 2002-05-04 티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체
EP03721130A EP1501811B1 (en) 2002-05-04 2003-05-01 Process for preparing thiazole derivative and the intermediate compounds for preparing the same
PCT/KR2003/000877 WO2003106442A1 (en) 2002-05-04 2003-05-01 Process for preparing thiazole derivative and the intermediate compounds for preparing the same
ES03721130T ES2330095T3 (es) 2002-05-04 2003-05-01 Procedimiento para preparar un derivado de tiazol y compuestos intermedios para su preperacion.
US10/513,408 US7241901B2 (en) 2002-05-04 2003-05-01 Process for preparing thiazole derivative and the intermediate compounds for preparing the same
DE60328376T DE60328376D1 (de) 2002-05-04 2003-05-01 Verfahren zur herstellung eines thiazolderivats und zwischenprodukte für dessen herstellung
JP2004513274A JP2005536480A (ja) 2002-05-04 2003-05-01 チアゾール誘導体の製造方法及びこれを製造するための中間体
CNB038100819A CN100457744C (zh) 2002-05-04 2003-05-01 噻唑衍生物的制备方法和用于制备噻唑衍生物的中间体化合物
US11/730,658 US20070179300A1 (en) 2002-05-04 2007-04-03 Process for preparing thiazole derivative and the intermediate compounds for preparing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR10-2002-0024595A KR100474202B1 (ko) 2002-05-04 2002-05-04 티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체

Publications (2)

Publication Number Publication Date
KR20030086373A KR20030086373A (ko) 2003-11-10
KR100474202B1 true KR100474202B1 (ko) 2005-03-08

Family

ID=29728605

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2002-0024595A Expired - Fee Related KR100474202B1 (ko) 2002-05-04 2002-05-04 티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체

Country Status (8)

Country Link
US (2) US7241901B2 (enExample)
EP (1) EP1501811B1 (enExample)
JP (1) JP2005536480A (enExample)
KR (1) KR100474202B1 (enExample)
CN (1) CN100457744C (enExample)
DE (1) DE60328376D1 (enExample)
ES (1) ES2330095T3 (enExample)
WO (1) WO2003106442A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101005020B1 (ko) 2006-12-13 2010-12-30 대전대학교 산학협력단 신규 쿠마린 유도체 및 이를 함유하는 항염증, 항알러지용조성물

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2598821C (en) * 2004-12-31 2011-05-31 Heonjoong Kang Organoselenium containing compounds and their use
KR100753860B1 (ko) * 2004-12-31 2007-08-31 재단법인서울대학교산학협력재단 유기 셀레늄 함유 화합물 및 이들 화합물의 용도
WO2006091047A1 (en) * 2005-02-25 2006-08-31 Heonjoong Kang Thiazole derivatives as ppar delta ligands and their manufacturing process
BRPI0606232A2 (pt) * 2005-02-25 2009-06-09 Kang Heonjoong derivados de tiazole como os ligantes delta ppar e seus processos de produção
US7982050B2 (en) 2005-05-07 2011-07-19 Seoul National University Industry Foundation Process for preparing ligands of PPARdelta and the intermediate compounds for preparing the same
CN101400663A (zh) * 2006-01-10 2009-04-01 史密丝克莱恩比彻姆公司 {2-甲基-4-[4-甲基-2-(4-三氟甲基苯基)噻唑-5-基甲硫基]苯氧基}-乙酸的多晶型
KR100954237B1 (ko) 2007-01-08 2010-04-21 재단법인서울대학교산학협력재단 퍼록시솜 증식자 활성화 수용체 델타 리간드 티아졸 화합물및 이를 함유하는 의약, 화장품 및 건강식품 조성물
CN107879994A (zh) * 2017-10-31 2018-04-06 广西师范大学 一种噻唑类化合物的合成方法
CN109897013B (zh) * 2019-03-31 2023-04-07 无锡科华生物科技有限公司 一种选择性PPARδ激动剂GW501516的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000603A1 (en) * 1999-06-25 2001-01-04 Glaxo Group Limited Thiazole and oxazole derivatives and their pharmaceutical use
US6204277B1 (en) * 1996-08-19 2001-03-20 Japan Tobacco Inc. Propionic acid derivatives and applications thereof
WO2001040207A1 (en) * 1999-12-02 2001-06-07 Glaxo Group Limited Substituted oxazoles and thiazoles derivatives as hppar alpha activators
US6506757B1 (en) * 1998-03-10 2003-01-14 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives and drugs containing the same as the active ingredient

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727187A (en) * 1984-06-15 1988-02-23 Ciba-Geigy Corporation Process for the preparation of α, α-difluoroalkyl phenyl ether derivatives
JPH06306005A (ja) * 1993-04-23 1994-11-01 Nippon Kayaku Co Ltd エーテル系化合物及びその製法
GB9817118D0 (en) * 1998-08-07 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
JP2001354671A (ja) * 2000-04-14 2001-12-25 Nippon Chemiphar Co Ltd ペルオキシソーム増殖剤応答性受容体δの活性化剤
ATE542805T1 (de) * 2000-08-11 2012-02-15 Nippon Chemiphar Co Ppar-delta aktivatoren
US7091225B2 (en) 2000-12-20 2006-08-15 Smithkline Beecham Corporation Substituted oxazoles and thiazoles as hPPAR alpha agonists
WO2002070011A2 (en) * 2001-02-02 2002-09-12 Smithkline Beecham Corporation Treatment of ppar mediated diseases
AU2003213281A1 (en) * 2002-02-28 2003-09-16 Smithkline Beecham Corporation Process and intermediates for preparing phenylthiomethyl-thiazoles or oxazoles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204277B1 (en) * 1996-08-19 2001-03-20 Japan Tobacco Inc. Propionic acid derivatives and applications thereof
US6506757B1 (en) * 1998-03-10 2003-01-14 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives and drugs containing the same as the active ingredient
WO2001000603A1 (en) * 1999-06-25 2001-01-04 Glaxo Group Limited Thiazole and oxazole derivatives and their pharmaceutical use
WO2001040207A1 (en) * 1999-12-02 2001-06-07 Glaxo Group Limited Substituted oxazoles and thiazoles derivatives as hppar alpha activators

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101005020B1 (ko) 2006-12-13 2010-12-30 대전대학교 산학협력단 신규 쿠마린 유도체 및 이를 함유하는 항염증, 항알러지용조성물

Also Published As

Publication number Publication date
US20050176785A1 (en) 2005-08-11
CN1649854A (zh) 2005-08-03
US20070179300A1 (en) 2007-08-02
CN100457744C (zh) 2009-02-04
KR20030086373A (ko) 2003-11-10
JP2005536480A (ja) 2005-12-02
ES2330095T3 (es) 2009-12-04
EP1501811A1 (en) 2005-02-02
WO2003106442A1 (en) 2003-12-24
DE60328376D1 (de) 2009-08-27
EP1501811A4 (en) 2006-02-08
EP1501811B1 (en) 2009-07-15
US7241901B2 (en) 2007-07-10

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