KR100424062B1 - 대식세포특이과립에 특이적으로 결합하는 항 GiM 항체 및 이의 검출방법 - Google Patents
대식세포특이과립에 특이적으로 결합하는 항 GiM 항체 및 이의 검출방법 Download PDFInfo
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- KR100424062B1 KR100424062B1 KR10-2000-0051166A KR20000051166A KR100424062B1 KR 100424062 B1 KR100424062 B1 KR 100424062B1 KR 20000051166 A KR20000051166 A KR 20000051166A KR 100424062 B1 KR100424062 B1 KR 100424062B1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
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Abstract
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Claims (13)
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- 대식세포에 과립이 존재하는지의 여부를 확인하는 방법으로서,상기 과립은 호중구 내에 존재하는 일차과립(azurophilic granule)과는 구별되는 과립으로서, 대식세포 내에 특이적으로 존재하는 대식세포특이과립(granules in macrophage; GiM)이며,(1) 피검대상으로부터 분리한 혈청을 대식세포특이과립 (granules in macrophage; GiM), 상기 대식세포특이과립을 함유하는 대식세포 또는 대식세포주와 접촉시키는 단계; 및(2) 항원항체반응을 이용하여 상기 혈청에 대식세포특이과립에 특이적인 항 GiM 항체가 존재하는지를 확인하고 그 역가를 측정하는 단계;를 포함하는 것을 항 GiM 항체를 검출하는 것에 의하여 대식세포에 과립이 존재하는지를 확인하는 방법.
- 제 10항에 있어서, 상기 항원항체반응은 간접면역형광법임을 특징으로 하는 방법.
- 제 11항에 있어서, 상기 간접면역형광법은 항 GiM 항체와 함께 항핵항체, 항 MTOC 항체 또는 항세포질 항체를 동시에 검출하는 것임을 특징으로 하는 방법.
- 제 10항에 있어서 상기 대식세포주는 IT-1 세포주(KFCC 10772)임을 특징으로 하는 방법.
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KR10-2000-0051166A KR100424062B1 (ko) | 2000-08-31 | 2000-08-31 | 대식세포특이과립에 특이적으로 결합하는 항 GiM 항체 및 이의 검출방법 |
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KR10-2000-0051166A KR100424062B1 (ko) | 2000-08-31 | 2000-08-31 | 대식세포특이과립에 특이적으로 결합하는 항 GiM 항체 및 이의 검출방법 |
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KR20020017676A KR20020017676A (ko) | 2002-03-07 |
KR100424062B1 true KR100424062B1 (ko) | 2004-03-22 |
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KR10-2000-0051166A KR100424062B1 (ko) | 2000-08-31 | 2000-08-31 | 대식세포특이과립에 특이적으로 결합하는 항 GiM 항체 및 이의 검출방법 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20210149435A (ko) * | 2020-06-02 | 2021-12-09 | 경북대학교 산학협력단 | 자가면역질환 진단을 위한 항핵항체 역가측정 방법 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101012193B1 (ko) * | 2010-06-30 | 2011-02-08 | 김수득 | 해안 소파블록 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR960005733A (ko) * | 1994-07-20 | 1996-02-23 | 미따라이 하지메 | 전자 방출 소자의 제조 방법, 전자 방출 소자를 이용한 전자원 및 화상 형성 장치 |
KR0182853B1 (ko) * | 1995-08-07 | 1999-05-15 | 김신규 | 자가면역 질환의 진단 방법 |
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- 2000-08-31 KR KR10-2000-0051166A patent/KR100424062B1/ko active IP Right Grant
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR960005733A (ko) * | 1994-07-20 | 1996-02-23 | 미따라이 하지메 | 전자 방출 소자의 제조 방법, 전자 방출 소자를 이용한 전자원 및 화상 형성 장치 |
KR0182853B1 (ko) * | 1995-08-07 | 1999-05-15 | 김신규 | 자가면역 질환의 진단 방법 |
Non-Patent Citations (5)
Title |
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Acta Cytol 1997 Mar-Apr;41(2):357-63 * |
Am J Pathol 1993 May;142(5) :1359-72 * |
Brain 1998 Mar;121 ( Pt 3):469-79 * |
Clin Endocrinol(Oxf) 1989 Jul;31(1) : 1-13 * |
Clin Immunol Immunopathol 1991 Feb;58(2):217-35 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20210149435A (ko) * | 2020-06-02 | 2021-12-09 | 경북대학교 산학협력단 | 자가면역질환 진단을 위한 항핵항체 역가측정 방법 |
KR102401369B1 (ko) | 2020-06-02 | 2022-05-24 | 경북대학교 산학협력단 | 자가면역질환 진단을 위한 항핵항체 역가측정 방법 |
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