KR100372751B1 - 생체조직공학용 다공성 생분해성 고분자 지지체의 제조방법 - Google Patents

생체조직공학용 다공성 생분해성 고분자 지지체의 제조방법 Download PDF

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Publication number
KR100372751B1
KR100372751B1 KR10-1999-0050922A KR19990050922A KR100372751B1 KR 100372751 B1 KR100372751 B1 KR 100372751B1 KR 19990050922 A KR19990050922 A KR 19990050922A KR 100372751 B1 KR100372751 B1 KR 100372751B1
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KR
South Korea
Prior art keywords
polymer
salt
biodegradable polymer
acid
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR10-1999-0050922A
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English (en)
Korean (ko)
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KR20010046941A (ko
Inventor
윤준진
박태관
Original Assignee
한국과학기술원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 한국과학기술원 filed Critical 한국과학기술원
Priority to KR10-1999-0050922A priority Critical patent/KR100372751B1/ko
Priority to EP00905419A priority patent/EP1165749B1/en
Priority to US09/700,458 priority patent/US6586246B1/en
Priority to PCT/KR2000/000106 priority patent/WO2000055300A1/en
Priority to ES00905419T priority patent/ES2291189T3/es
Priority to AT00905419T priority patent/ATE368728T1/de
Priority to JP2000605718A priority patent/JP2002538914A/ja
Priority to DE60035775T priority patent/DE60035775T2/de
Priority to NZ508148A priority patent/NZ508148A/en
Priority to AU71600/00A priority patent/AU780321B2/en
Priority to CA002326057A priority patent/CA2326057A1/en
Priority to IL139715A priority patent/IL139715A/en
Priority to HU0004498A priority patent/HUP0004498A3/hu
Priority to SG200006625A priority patent/SG92758A1/en
Priority to CNB001326376A priority patent/CN1169948C/zh
Priority to BRPI0005413-5A priority patent/BR0005413B1/pt
Priority to ARP000106064A priority patent/AR026510A1/es
Publication of KR20010046941A publication Critical patent/KR20010046941A/ko
Application granted granted Critical
Publication of KR100372751B1 publication Critical patent/KR100372751B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/0014—Use of organic additives
    • C08J9/0023—Use of organic additives containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/06—Biodegradable
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Materials For Medical Uses (AREA)
  • Biological Depolymerization Polymers (AREA)
KR10-1999-0050922A 1999-03-18 1999-11-16 생체조직공학용 다공성 생분해성 고분자 지지체의 제조방법 Expired - Fee Related KR100372751B1 (ko)

Priority Applications (17)

Application Number Priority Date Filing Date Title
KR10-1999-0050922A KR100372751B1 (ko) 1999-11-16 1999-11-16 생체조직공학용 다공성 생분해성 고분자 지지체의 제조방법
US09/700,458 US6586246B1 (en) 1999-03-18 2000-02-12 Preparing porous biodegradable polymeric scaffolds for tissue engineering using effervescent salts
PCT/KR2000/000106 WO2000055300A1 (en) 1999-03-18 2000-02-12 Method for preparing porous, biodegradable and biocompatible, polymeric scaffolds for tissue engineering
ES00905419T ES2291189T3 (es) 1999-03-18 2000-02-12 Procedimiento para la preparacion de armazones polimericos, porosos, biodegradables y biocompatibles para ingenieria tisular.
AT00905419T ATE368728T1 (de) 1999-03-18 2000-02-12 Verfahren zur herstellung von porösen, biologisch abbaubaren und biokompatiblen polymeren stützgeweben zur gewebetechnologie
JP2000605718A JP2002538914A (ja) 1999-03-18 2000-02-12 生体組織工学用多孔性生分解性生適合性高分子支持体の製造方法
DE60035775T DE60035775T2 (de) 1999-03-18 2000-02-12 VERFAHREN ZUR HERSTELLUNG VON PORöSEN, BIOLOGISCH ABBAUBAREN UND BIOKOMPATIBLEN POLYMEREN STüTZGEWEBEN ZUR GEWEBETECHNOLOGIE
EP00905419A EP1165749B1 (en) 1999-03-18 2000-02-12 Method for preparing porous, biodegradable and biocompatible, polymeric scaffolds for tissue engineering
NZ508148A NZ508148A (en) 1999-11-16 2000-11-14 Method for preparing a porous foam material by dissolving the polymer and mixing in a carbonate compound
AU71600/00A AU780321B2 (en) 1999-11-16 2000-11-14 Method for preparing biocompatible scaffold and scaffold prepared therefrom
IL139715A IL139715A (en) 1999-11-16 2000-11-15 Method for preparing biocompatible scaffold
HU0004498A HUP0004498A3 (en) 1999-11-16 2000-11-15 Method for preparing biocompatible scaffold and scaffold prepared there form
SG200006625A SG92758A1 (en) 1999-11-16 2000-11-15 Method for preparing biocompatible scaffold and scaffold prepared therefrom
CA002326057A CA2326057A1 (en) 1999-11-16 2000-11-15 Method for preparing biocompatible scaffold and scaffold prepared therefrom
CNB001326376A CN1169948C (zh) 1999-11-16 2000-11-16 生物相容的支架的制备方法及由该方法制备的支架
BRPI0005413-5A BR0005413B1 (pt) 1999-11-16 2000-11-16 processo para preparar uma plataforma polimÉrica porosa, biodegradÁvel e biocompatÍvel para engenharia de tecidos.
ARP000106064A AR026510A1 (es) 1999-11-16 2000-11-16 Metodo para preparar un soporte polimerico poroso biocompatible y biodegradable y soporte preparado por dicho metodo

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR10-1999-0050922A KR100372751B1 (ko) 1999-11-16 1999-11-16 생체조직공학용 다공성 생분해성 고분자 지지체의 제조방법

Publications (2)

Publication Number Publication Date
KR20010046941A KR20010046941A (ko) 2001-06-15
KR100372751B1 true KR100372751B1 (ko) 2003-02-17

Family

ID=19620369

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-1999-0050922A Expired - Fee Related KR100372751B1 (ko) 1999-03-18 1999-11-16 생체조직공학용 다공성 생분해성 고분자 지지체의 제조방법

Country Status (10)

Country Link
KR (1) KR100372751B1 (https=)
CN (1) CN1169948C (https=)
AR (1) AR026510A1 (https=)
AU (1) AU780321B2 (https=)
BR (1) BR0005413B1 (https=)
CA (1) CA2326057A1 (https=)
HU (1) HUP0004498A3 (https=)
IL (1) IL139715A (https=)
NZ (1) NZ508148A (https=)
SG (1) SG92758A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100963435B1 (ko) 2008-06-19 2010-06-17 한국과학기술연구원 서방형 약물전달 및 조직재생용 덮인 다공성 생분해성고분자 미립구의 제조 방법
KR101003749B1 (ko) 2008-09-19 2010-12-23 문형순 폴리락타이드를 이용한 다공성 소재의 제조 방법

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100532543C (zh) * 2001-12-24 2009-08-26 财团法人工业技术研究院 体外骨组织的培养方法及其多孔隙载体
KR100629392B1 (ko) * 2002-05-10 2006-09-29 주식회사 리젠 바이오텍 스케폴드를 이용한 체외에서의 정자 배양방법
KR100499096B1 (ko) * 2002-09-13 2005-07-01 이진호 조직공학용 다공성 고분자 지지체의 제조방법
EP2295036A2 (en) 2004-12-10 2011-03-16 Talima Therapeutics, Inc. Liquid compositions and methods for treating conditions of the nail unit
US20060275230A1 (en) 2004-12-10 2006-12-07 Frank Kochinke Compositions and methods for treating conditions of the nail unit
CN100431622C (zh) * 2005-12-08 2008-11-12 东南大学 组织工程用聚合物多孔支架材料的方法及其制备装置
WO2007107038A1 (en) * 2006-03-20 2007-09-27 Hua Liu Constructing tumor model in vitro and its application
KR100760511B1 (ko) * 2006-11-16 2007-10-04 한국과학기술연구원 과산화수소를 이용한 조직공학용 다공성 생분해 고분자지지체의 제조 방법
CN101147810B (zh) * 2007-11-01 2010-05-19 南昌大学第一附属医院 细胞-生物可降解材料复合物及其制备方法和应用
KR101739630B1 (ko) * 2011-12-01 2017-05-24 후지소프트 가부시키가이샤 연골 세포가 부착된 다공질체의 장기 보존 방법
CA2904703A1 (en) 2013-03-14 2014-10-02 Hallux, Inc. Method of treating infections, diseases or disorders of nail unit
CN106701570A (zh) * 2015-08-18 2017-05-24 重庆润泽医药有限公司 一种组织细胞培养装置
WO2017099261A1 (ko) * 2015-12-07 2017-06-15 주식회사 글로원 염침출 및 침지침강법을 이용한 스캐폴더 제조방법 및 그 스캐폴더
US12102973B2 (en) 2015-12-18 2024-10-01 Safeguard Biosystems Holdings Ltd. Three-dimensional polymer networks with channels situated therein
EP3418741A1 (en) * 2017-06-19 2018-12-26 Safeguard Biosystems Holdings Ltd. Three-dimensional polymer networks and their use
CN110947035B (zh) * 2019-10-30 2022-04-05 中山大学附属第六医院 一种p4hb补片表面多孔化改性的方法及p4hb补片
CN114958709B (zh) * 2021-12-07 2024-04-19 中科睿极(海宁)生物科技有限公司 可快速崩解的微载体聚集体及其制备方法
CN115645609A (zh) * 2021-12-30 2023-01-31 盐城工业职业技术学院 一种三维多孔生物可降解聚合物人工食管支架及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514378A (en) * 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
WO2000055300A1 (en) * 1999-03-18 2000-09-21 Korea Advanced Institute Of Science And Technology Method for preparing porous, biodegradable and biocompatible, polymeric scaffolds for tissue engineering
KR100288488B1 (ko) * 1999-03-18 2001-04-16 윤덕용 발포성 염을 이용한 생체조직공학용 다공성 고분자 지지체의 제조방법

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US5502092A (en) * 1994-02-18 1996-03-26 Minnesota Mining And Manufacturing Company Biocompatible porous matrix of bioabsorbable material
US5723508A (en) * 1996-01-25 1998-03-03 Northwestern University Method of fabricating emulsion freeze-dried scaffold bodies and resulting products
US6165486A (en) * 1998-11-19 2000-12-26 Carnegie Mellon University Biocompatible compositions and methods of using same
US6103255A (en) * 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514378A (en) * 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
WO2000055300A1 (en) * 1999-03-18 2000-09-21 Korea Advanced Institute Of Science And Technology Method for preparing porous, biodegradable and biocompatible, polymeric scaffolds for tissue engineering
KR100288488B1 (ko) * 1999-03-18 2001-04-16 윤덕용 발포성 염을 이용한 생체조직공학용 다공성 고분자 지지체의 제조방법

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100963435B1 (ko) 2008-06-19 2010-06-17 한국과학기술연구원 서방형 약물전달 및 조직재생용 덮인 다공성 생분해성고분자 미립구의 제조 방법
US8192655B2 (en) 2008-06-19 2012-06-05 Korea Institute Of Science And Technology Method of preparing covered porous biodegradable polymer microspheres for sustained-release drug delivery and tissue regeneration
KR101003749B1 (ko) 2008-09-19 2010-12-23 문형순 폴리락타이드를 이용한 다공성 소재의 제조 방법

Also Published As

Publication number Publication date
CN1169948C (zh) 2004-10-06
HUP0004498A2 (hu) 2001-10-28
HU0004498D0 (https=) 2001-01-29
BR0005413A (pt) 2001-08-07
AU7160000A (en) 2001-05-17
AU780321B2 (en) 2005-03-17
CA2326057A1 (en) 2001-05-16
NZ508148A (en) 2002-05-31
IL139715A0 (en) 2002-02-10
HUP0004498A3 (en) 2003-10-28
AR026510A1 (es) 2003-02-12
KR20010046941A (ko) 2001-06-15
CN1297042A (zh) 2001-05-30
SG92758A1 (en) 2002-11-19
BR0005413B1 (pt) 2012-08-07
IL139715A (en) 2006-06-11

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