KR100289671B1 - Skin Cosmetic Composition Containing Pine Extract and Saccharide Isomerate - Google Patents

Abstract

In order to improve skin wrinkles and give skin elasticity, skin irritation is significantly reduced by using a mixture of pine extract and saccharide isomerate for the purpose of alleviating skin irritation among cosmetics containing hydroxy acid. In particular it relates to an improved skin cosmetic composition which may be useful in real life.

Description

SKIN COSMETIC COMPOSITION CONTAINING SONG-I MUSHROOM EXTRACT AND SACCHARIDE ISOMERATE

The present invention relates to a skin cosmetic composition comprising a hydroxy acid to improve skin wrinkles and impart elasticity to the skin. More specifically, the present invention includes pine extract and saccharide isomerate together with hydroxy acid to improve skin wrinkles and give skin elasticity while significantly reducing skin irritation and especially useful in real life. It relates to a cosmetic composition.

Human skin is a complex of organic matter spread throughout the body and is divided into various types depending on where it is located. For example, the skin on the face is different from the skin on the scalp, and the skin inside the arm may be different from the skin on the back. However, even if the skin is all different depending on the location, it consists of three layers of skin, dermis and subcutaneous tissue. Nails and toenails are also different types of skin. The cosmetic interest in the skin has been the subject of interest from the past, and recently, attention has been focused on the natural anti-aging and photo aging, and the interest in the ultimate anti-wrinkle is increased through the improvement of fine wrinkles by improving the elasticity of skin tissues or promoting the growth of skin tissues. It is becoming. Based on the results of this series of studies, hydroxy acid or retinoid has been shown to be effective for anti-wrinkle effect as it has a special effect on sunlight photoaging and natural skin aging.

U.S. Patent No. 3,897,537 describes the use of alpha hydroxy acids, keto acids and their esters and the like. Unfortunately, when applied to cosmetics as hydroxy acids or retinoids, it is well known that significant concentrations must be maintained to achieve the above objectives, and that the negative effects of these factors can cause skin irritation such as erythema on the skin. to be. Therefore, in order not to cause skin irritation, it is necessary to reduce the amount of use in the cosmetics or limit the skin penetration content of the raw material, but both of them are in terms of anti-wrinkle effect, which is the ultimate purpose of hydroxy acid or retinoid as a cosmetic composition. Not appropriate

As a method of reducing skin irritation related to hydroxy acid, a method of increasing the concentration of hydrogen ions in the final cosmetic product while maintaining the concentration of hydroxy acid as a cosmetic composition has been proposed. This affects and eventually makes anti-wrinkle effect hard to expect. But from another point of view, even though it may be effective to reduce skin irritation, another negative effect by the stimulant alleviators, such as reducing the anti-wrinkle effect or suffering from numbness or lidocaine of the skin, There should be no local anesthesia that involves the neurotransmitter system in the brain and neurons and blocks the response.

EP 0631722 (Johnson & Johnson) describes the use of glycolic acid to reduce skin irritation induced by retinol.

U.S. Patent No. 5,252,604 to Nagy et al. Describes the use of tocopherols to reduce skin irritation caused by retinol.

US 5,516,793 (Dully) describes a method for improving skin irritation using ascorbic acid for stimulation that may be caused by various active agents, including hydroxy acids or retinoids. Ascorbic acid, Vitamin C, activates fibroblasts, which promote the production of fibrous tissues, especially collagen, while reducing skin irritation.

U.S. Patent No. 5,690,947 (Chesebrough-Pond's) describes the use of linoleic acid as an amino acid contained in a large amount of borage seeds to reduce skin irritation of hydroxy acids or retinoids.

In general, cosmetics containing hydroxy acid may cause skin irritation, and exposing keratinocytes under low hydrogen ion concentration to exfoliate keratinocytes under harmful hydrogen conditions, such as harmful environments such as windy, dry weather or strong ultraviolet rays. It is common to feel more irritated than possible.

Document SOFW-Journal, 121. Jahrgang 14/95 describes a method for reducing skin irritation caused by AHA as a cosmetic containing AHA using saccharide isomerate. However, although the above-mentioned document mentions improving the skin irritation by AHA while increasing the moisturizing effect, there is no mention of a method of improving the skin irritation while protecting the skin from harmful ultraviolet rays. Cosmetics are an important factor to consider ultraviolet rays because they are used in real life in harmful ultraviolet rays.

In the cosmetic composition containing hydroxy acid, the hydroxy acid prevents or improves skin wrinkles, and can significantly reduce skin irritation without negative effects, namely numbness or anesthesia, and also provides sufficient moisture and harmful skin There is a need to continue to develop improved cosmetic composition with a function to protect the.

The present inventors unexpectedly showed synergistically reduced stimulation in a concentration-dependent manner when used in a skin cosmetic composition containing hydroxy acid and with saccharide isomerate. It has been found to be useful.

Therefore, the present invention contains a high concentration of hydroxy acid to improve skin wrinkles and give elasticity to the skin, and use a mixture of pine extract and saccharide isomerate for the purpose of alleviating skin irritation in cosmetics adjusted to pH below 4.0 This provides an improved skin cosmetic composition that can significantly reduce skin irritation and be very useful in real life.

As a cosmetic containing hydroxy acid in general, the skin layer becomes so sensitive during the process of promoting turnover of keratinocytes and promoting the growth of fibroblasts and ultimately improving fine wrinkles, so that the skin layer is sensitive to the external environment. Therefore, be prepared for UV rays, pollution, dry climate (dry skin). The use of such anti-wrinkle cosmetics has often resulted in skin side effects or rather hyperpigmentation on the skin, due to the lack of thorough UV protection during the treatment. Therefore, in the period of treatment of cosmetics containing hydroxy acid, the most important thing along with thorough sun protection is thorough skin moisturizing.

In the present invention, the saccharide extract is mixed with saccharide isomerate and added to the cosmetics containing hydroxy acid as a raw material, thereby providing sufficient moisturizing effect, as well as the harmfulness of the natural pine extract without toxicity, not synthetic. By protecting the skin with UV protection, it was possible to significantly reduce the skin irritation caused by hydroxy acid without further irritation.

Cluster extract used in the present invention can be prepared according to the following process. The mushrooms were washed with clean water, crushed to remove various dispersions, and then dried at room temperature for several days. 500 grams of ethanol was mixed as a solvent per 100 grams of clusters, and the mixture was further ground and stirred and mixed with a grinder. After centrifugation again, the supernatant is taken, and then it is aged for another week. It is filtered again 200 times to separate residual impurities. It was again concentrated under reduced pressure at room temperature and dried at low temperature to obtain a powdery cluster extract. It may be used by dissolving it at a constant concentration in 1,3-butylene glycol or glycerin for convenience of the manufacturing process.

As another method, the pine extract used in the present invention may be purchased and used as a commercial product, for example, TRICHOLOMA MASUTAKE manufactured by CAMPO of Singapore.

The mixture of pine extract and saccharide isomerate used in the present invention exhibits a significant reduction in stimulation when each of these components is used, as well as a small rate of stimulus change with time of use, which can be very useful in real life. It is characterized by the use of the mixture in that respect.

Significantly reducing effect in the present invention is to use the cluster extract and saccharide isomerate in combination of at least 0.5% to up to 20% based on the total weight of the composition and within this range cluster extract to saccharide isomerate The ratio of is 10:90 to 90:10. In particular, it was found that when the same amount of the pine extract and saccharide isomerate were used in the same amount, the irritation was remarkably alleviated while living in harmful ultraviolet rays.

Another advantage of the cosmetic composition of the present invention with the effect of reducing the stimulus is that the rate of change of the stimulus with time of use is small and can be practically useful in real life. That is, according to the present invention, a cosmetic composition containing a mixture of pine extract and saccharide isomerate has a low irritation change rate when compared to a cosmetic composition containing only one of these components in the same amount, so that those skilled in the art will appreciate the cosmetic composition of the present invention. It will be appreciated that this is commercially very advantageous.

Hereinafter, the present invention is specifically illustrated by way of examples and comparative examples. However, the following examples should not be understood as limiting the invention.

Examples 1 to 3 and Comparative Examples 1 to 3

The present invention was conducted in vivo in 16 women in their 30s and 40s for the purpose of improving skin irritation of hydroxy acid as an anti-wrinkle cosmetic. The subjects were all those who showed fine wrinkles due to aging, and all of them were restricted to those with dry or sensitive skin. All experiments were conducted for 4 weeks.

One week before the clinical trial, no general moisturizer, sunscreen, or make-up was done. Only twice a day (morning and evening) soap was washed and in a healthy condition without any skin irritation during the period.

At the beginning of the experiment an O / W emulsion containing hydroxy acid was used and the base formulations all contained 5% lactic acid and were neutralized with triethanol amine to maintain the pH of the final composition 3.8.

Base formulations also contained no known skin irritant or plant extracts and also excluded other irritants, fragrances and pigments. In the base O / W emulsion formulation, 10% cluster extract in 1,3-butylene glycol solution: saccharide isomerate (50: 50% by weight) and separate cluster extract or saccharide isomerate while varying the content The control was made free of stimulants. Base preparation method is shown in Table 1 below.

TABLE 1 (Capacity is by weight%)

division Raw material name Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 A Polysorbate 60 0.5 0.5 0.5 0.5 0.5 0.5 Cetyl alcohol 1.5 0.5 0.5 0.5 0.5 0.5 Stearyl alcohol 0.5 0.5 0.5 0.5 0.5 0.5 Liquid paraffin 5.0 5.0 5.0 5.0 5.0 5.0 Squalane 2.0 2.0 2.0 2.0 2.0 2.0 Profile paraben 1.0 0.1 0.1 0.1 0.1 0.1 B glycerin 10.0 10.0 10.0 10.0 10.0 10.0 Lactic acid (hydroxy acid) 5.0 5.0 5.0 5.0 5.0 5.0 Methyl Paraben 0.2 0.2 0.2 0.2 0.2 0.2 Purified water to 100 to 100 to 100 to 100 to 100 to 100 C Triethanol amine Quantity Quantity Quantity Quantity Quantity Quantity D Pine extract - 1.0 - 0.5 1.0 2.0 Saccharide Isomerate - 1.0 0.5 1.0 2.0 The state A was completely dissolved by heating to 75 ° C. and the state B was completely dissolved by heating to 80 ° C. Using a home mixer, A was slowly added to B while stirring and emulsifying at 2500 rpm. While slowly cooling, C was added at 45 ° C. to adjust the pH to 3.8, and then D was added thereto, cooled to 30 ° C., and then stopped.

Laboratory Example 1

Skin irritation test (patch test)

In order to test the skin irritation, the degree of irritation was evaluated 24 hours after applying the formulations of Comparative Examples 1 to 3 according to the patch test in the upper arm of 16 female subjects. Table 2 below shows the results.

TABLE 2

Skin irritation result average Irritancy judgment compare A Comparative Example 1 Prescription 32.9 3 Irritation Determination 1: Minimum stimulation (less than 10) 2: Mild stimulation (10.1 ~ 20) 3: Moderate stimulation (20.1 ~ 40) 4: Severe stimulation (40.1 or more) B Comparative Example 2 Prescription 27.2 3 C Comparative Example 3 Prescription 23.7 3 D Example 1 Prescription 24.2 3 E Example 2 Prescription 15.4 2 F Example 3 Prescription 13.6 2

A) without skin irritant has severe skin irritation, and skin irritation is alleviated in B), C) and D), but skin irritation is significantly reduced in both E) and F) depending on concentration. can see.

However, the present invention is not intended to expect only the skin irritation relief of C). That's because patch experiments don't take into account the real-world UV sector. As described above, when using a cosmetic containing a hydroxy acid, it is necessary to prevent harmful ultraviolet rays.

Experimental Example 2

Relieve skin irritation during real-world experiments

Sixteen test subjects were divided into two groups and half-face experiments were conducted over four weeks.

The experimental method was applied to the left side of the subject's face with a comparative example 1 without a stimulant alleviator and applied to the comparative example 3 with a skin irritation-releasing effect on the right side, and it was observed that it was noticeable like itching, erythema, and millet. 1.0%)-Group 1.

Another group 2 applied the comparative example 1 prescription to the left side of the subject's face and applied the example 1 prescription (containing saccharide isomerate 0.5% + cluster extract 0.5%) on the right side to similarly itch, erythema, millet 4 Observed over the day.

The evaluation was performed on a 7-point scale, and the final questionnaire was received 4 weeks after the initial questionnaire.

The results are shown in Tables 3 and 4 below.

[Table 3] Skin irritation results (containing 1.0% of saccharide isomerate)

Subject number Comparative Example 1 Prescription Comparative Example 3 Prescription-(Contains 1.0% Saccaride Isomerate) Early 4 weeks later Early 4 weeks later One 3 4 3 3 2 4 4 4 3 3 4 5 4 5 4 3 5 3 4 5 3 5 3 3 6 3 4 3 4 7 4 4 4 5 8 4 4 4 5 medium 3.5 4.375 3.5 4.0 % Change 25.0% (stimulation increase) 14.3% (stimulation increase) Evaluation standard 1 point (very weak) ↔ 3 points (normal) ↔ 7 points (very strong)

Due to the nature of the hydroxy acid-containing cosmetics, the irritation increase rate was not abrupt due to the inclusion of an irritant.

[Table 4] Skin irritation results (containing 0.5% of saccharide isomerate + 0.5% of cluster extract)

Subject number Comparative Example 1 Prescription Example 1 Prescription (Saccharide Isomerate 0.5% + Cluster Extract 0.5%) Early 4 weeks later Early 4 weeks later One 3 4 3 3 2 4 3 4 3 3 3 5 3 3 4 3 4 3 4 5 3 5 3 3 6 3 4 3 4 7 3 4 3 4 8 4 4 4 3 medium 3.25 4.25 3.25 3.375 % Change 26.9% (stimulation increase) 3.8% (stimulation increase) Evaluation standard 1 point (very weak) ↔ 3 points (normal) ↔ 7 points (very strong)

Skin irritation is not severely shown by the formulation of Example 1, which contains saccharide isomerate and matsutake extract to prevent harmful ultraviolet rays and enhances moisturizing effect during actual use.

In the end, the results of group 1 are meaningful to alleviate the skin irritation caused by saccharide isomerate, but the results of group 2 are mixed with pine extract and saccharide isomerate. Show that the stimulus is alleviated.

The present invention can reduce the skin irritation by using saccharide isomerate for the purpose of alleviating the skin irritation among the cosmetics containing hydroxy acid in order to improve the fine wrinkles and give the skin elasticity, but the harmful ultraviolet rays to be considered in real life By applying the natural cluster extracts together with saccharide isomerates without the use of synthetic sunscreens, which can cause further toxicity, the synergistically significantly reduces skin irritation as a cosmetic containing hydroxy acid and also at the time of use. It provides an improved cosmetic composition that can be very useful in real life due to the low rate of stimulus change.

Claims (3)

A cosmetic composition having a high concentration of hydroxy acid and having a pH of 4.0 or less, wherein the cosmetic composition is characterized in that it comprises pine extract and saccharide isomerate. The composition of claim 1 wherein the ratio and amount of pine extract to saccharide isomerate is 0.5% to 20% based on the total weight of the composition in the range of 10: 90% to 90: 10% by weight. The composition of claim 2 wherein the cluster extract and the saccharide isomerate are included in the same amount.