KR100254135B1 - 관절염의 진단 및/ 또는 치료를 위한 방법 및 약제 - Google Patents

관절염의 진단 및/ 또는 치료를 위한 방법 및 약제 Download PDF

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Publication number
KR100254135B1
KR100254135B1 KR1019940008364A KR19940008364A KR100254135B1 KR 100254135 B1 KR100254135 B1 KR 100254135B1 KR 1019940008364 A KR1019940008364 A KR 1019940008364A KR 19940008364 A KR19940008364 A KR 19940008364A KR 100254135 B1 KR100254135 B1 KR 100254135B1
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KR
South Korea
Prior art keywords
group
cooh
amino
acid
tetrapyrrole
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Expired - Lifetime
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KR1019940008364A
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English (en)
Korean (ko)
Inventor
가쓰오 아이자와
유카리 구로이와
Original Assignee
사이카와 겐조오
니뽄 세키유 가가쿠 가부시키가이샤
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Application granted granted Critical
Publication of KR100254135B1 publication Critical patent/KR100254135B1/ko
Assigned to 신니혼 세키유 가부시키가이샤 reassignment 신니혼 세키유 가부시키가이샤 권리의 전부이전등록 Assignors: 신니뽄세키유가가쿠 가부시키가이샤
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019940008364A 1993-04-22 1994-04-20 관절염의 진단 및/ 또는 치료를 위한 방법 및 약제 Expired - Lifetime KR100254135B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP93-120977 1993-04-22
JP12097793A JP3565442B2 (ja) 1993-04-22 1993-04-22 哺乳類の関節炎の診断剤および／または治療剤

Publications (1)

Publication Number Publication Date
KR100254135B1 true KR100254135B1 (ko) 2000-05-01

Family

ID=14799730

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940008364A Expired - Lifetime KR100254135B1 (ko) 1993-04-22 1994-04-20 관절염의 진단 및/ 또는 치료를 위한 방법 및 약제

Country Status (7)

Country Link
US (2) US5430051A (cg-RX-API-DMAC7.html)
EP (1) EP0629409A1 (cg-RX-API-DMAC7.html)
JP (1) JP3565442B2 (cg-RX-API-DMAC7.html)
KR (1) KR100254135B1 (cg-RX-API-DMAC7.html)
CN (1) CN1074665C (cg-RX-API-DMAC7.html)
CA (1) CA2121716C (cg-RX-API-DMAC7.html)
TW (1) TW259706B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101456839B1 (ko) * 2006-06-30 2014-11-03 유로-셀티큐 에스.에이. 광활성제 조성물 및 광활성제의 제조 방법

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807881A (en) 1992-05-27 1998-09-15 Quadra Logic Technologies, Inc. Method for selectively reducing activated leukocyte cell population
AU6031096A (en) * 1995-06-05 1996-12-24 Duke University Nitrosylated and nitrated superoxide oxidants and reductants
WO1998015273A1 (en) * 1996-10-10 1998-04-16 The General Hospital Corporation Photodynamic therapy for the treatment of osteoarthritis
CA2270558C (en) * 1996-11-06 2006-08-15 Meiji Seika Kaisha, Ltd. Treatment of autoimmune diseases by photochemotherapy
US5952664A (en) * 1997-01-17 1999-09-14 Imaging Diagnostic Systems, Inc. Laser imaging apparatus using biomedical markers that bind to cancer cells
AU747753B2 (en) * 1997-08-05 2002-05-23 Meiji Seika Kaisha Ltd. Immunosuppression by photochemotherapy
EP1131100B1 (en) * 1999-01-15 2003-03-12 Light Sciences Corporation Therapeutic compositions for metabolic bone disorders or bone metastases comprising a photosensitizer and a bisphosphonate
US6602274B1 (en) * 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
WO2000041726A2 (en) * 1999-01-15 2000-07-20 Light Sciences Corporation Noninvasive vascular therapy
US20030114434A1 (en) * 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
CA2395567A1 (en) * 2000-01-12 2001-07-19 Light Sciences Corporation Novel treatment for eye disease
US20050154046A1 (en) * 2004-01-12 2005-07-14 Longgui Wang Methods of treating an inflammatory-related disease
US8563525B2 (en) 2004-01-12 2013-10-22 Natrogen Therapeutics International, Inc. Methods of treating an inflammatory-related disease
US7582670B2 (en) * 2001-12-13 2009-09-01 Natrogen Therapeutics, Inc. Methods of treating an inflammatory-related disease
WO2004002476A2 (en) 2002-06-27 2004-01-08 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
US7053210B2 (en) 2002-07-02 2006-05-30 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
EP1594875A4 (en) 2003-01-16 2007-07-11 Technomart Co Ltd porphyrin derivatives
US10376711B2 (en) * 2003-03-14 2019-08-13 Light Sciences Oncology Inc. Light generating guide wire for intravascular use
CN2885311Y (zh) 2006-01-18 2007-04-04 郑成福 经尿道光动力疗法前列腺治疗仪
US20080269846A1 (en) * 2003-03-14 2008-10-30 Light Sciences Oncology, Inc. Device for treatment of blood vessels using light
WO2007103427A2 (en) * 2006-03-06 2007-09-13 Wang Xiang H Medical use of bilirubin and its structural analogues
US8057464B2 (en) * 2006-05-03 2011-11-15 Light Sciences Oncology, Inc. Light transmission system for photoreactive therapy
EP2182835B1 (en) * 2007-08-14 2019-06-19 mivenion GmbH Device and procedure for the diagnosis or diagnostic preparation and/or therapy monitoring of inflammatory diseases such as rheumatoid arthritis
CN101426268B (zh) * 2007-11-02 2010-08-25 大唐移动通信设备有限公司 导频资源分配方法、系统和设备
WO2009065065A1 (en) * 2007-11-15 2009-05-22 Ceramoptec Industries, Inc. Pegylated liposomal formulations for photodynamic treatment of inflammatory diseases
CN107987081B (zh) * 2016-10-26 2019-12-06 刘辉 一种二氢卟吩e6衍生物及其药学上可接受的盐、其制备方法和应用
US20230330138A1 (en) * 2022-04-14 2023-10-19 Creative Medical Technologies, Inc. Treatment of cartilage degeneration using myeloid suppressor cells and exosomes derived thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3102891A (en) * 1959-11-16 1963-09-03 Elmer A Allen New porphyrinic and chlorophyllic compositions and process therefor
US4649151A (en) * 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
US4693885A (en) * 1984-07-18 1987-09-15 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US4675338A (en) * 1984-07-18 1987-06-23 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US4656186A (en) * 1985-04-30 1987-04-07 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US5066274A (en) * 1985-04-30 1991-11-19 Nippon Petrochemicals Company, Ltd. Tetrapyrrole therapeutic agents
US4977177A (en) * 1985-04-30 1990-12-11 Nippon Petrochemicals Company, Ltd. Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents
US5004811A (en) * 1987-12-24 1991-04-02 Nippon Petrochemicals Company, Ltd. Tetrapyrrole aminocarboxylic acids
US5028594A (en) * 1988-12-27 1991-07-02 Naxcor Use of photodynamic compositions for cytotoxic effects
US4997639A (en) * 1989-11-27 1991-03-05 Nippon Petrochemicals Company, Limited Method for detecting cholesterol deposited in bodies of mammals
JP3154742B2 (ja) * 1991-04-30 2001-04-09 日本石油化学株式会社 哺乳類の動脈硬化症治療剤
PT680365E (pt) * 1992-11-20 2000-07-31 Univ British Columbia Activacao de agentes fotossensibilizadores
US5368841A (en) * 1993-02-11 1994-11-29 The General Hospital Corporation Photodynamic therapy for the destruction of the synovium in the treatment of rheumatoid arthritis and the inflammatory arthritides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101456839B1 (ko) * 2006-06-30 2014-11-03 유로-셀티큐 에스.에이. 광활성제 조성물 및 광활성제의 제조 방법

Also Published As

Publication number Publication date
CN1074665C (zh) 2001-11-14
CN1099613A (zh) 1995-03-08
US5430051A (en) 1995-07-04
TW259706B (cg-RX-API-DMAC7.html) 1995-10-11
JPH06305961A (ja) 1994-11-01
JP3565442B2 (ja) 2004-09-15
EP0629409A1 (en) 1994-12-21
US5567409A (en) 1996-10-22
CA2121716A1 (en) 1994-10-23
CA2121716C (en) 2008-01-08

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