KR100200463B1 - 항혈소판 작용을 갖는 히루딘 동족체 - Google Patents

항혈소판 작용을 갖는 히루딘 동족체 Download PDF

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Publication number
KR100200463B1
KR100200463B1 KR1019910012636A KR910012636A KR100200463B1 KR 100200463 B1 KR100200463 B1 KR 100200463B1 KR 1019910012636 A KR1019910012636 A KR 1019910012636A KR 910012636 A KR910012636 A KR 910012636A KR 100200463 B1 KR100200463 B1 KR 100200463B1
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KR
South Korea
Prior art keywords
glu
pro
asp
ile
ala
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019910012636A
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English (en)
Korean (ko)
Other versions
KR930001927A (ko
Inventor
레오나르드 크르스테난스키 죤
제임스 브뢰스마 쥬니어 로버트
Original Assignee
슈테펜엘.네스비트
메렐 다우 파마슈티칼스 인크.
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Application filed by 슈테펜엘.네스비트, 메렐 다우 파마슈티칼스 인크. filed Critical 슈테펜엘.네스비트
Publication of KR930001927A publication Critical patent/KR930001927A/ko
Application granted granted Critical
Publication of KR100200463B1 publication Critical patent/KR100200463B1/ko
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Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
  • Corsets Or Brassieres (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1019910012636A 1990-07-24 1991-07-23 항혈소판 작용을 갖는 히루딘 동족체 Expired - Fee Related KR100200463B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55728990A 1990-07-24 1990-07-24
US557,289 1990-07-24

Publications (2)

Publication Number Publication Date
KR930001927A KR930001927A (ko) 1993-02-22
KR100200463B1 true KR100200463B1 (ko) 1999-06-15

Family

ID=24224808

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910012636A Expired - Fee Related KR100200463B1 (ko) 1990-07-24 1991-07-23 항혈소판 작용을 갖는 히루딘 동족체

Country Status (10)

Country Link
EP (1) EP0468448B1 (https=)
JP (1) JP3264283B2 (https=)
KR (1) KR100200463B1 (https=)
AT (1) ATE139121T1 (https=)
AU (1) AU640502B2 (https=)
DE (1) DE69120158T2 (https=)
ES (1) ES2090181T3 (https=)
IE (1) IE72961B1 (https=)
TW (1) TW209171B (https=)
ZA (1) ZA915658B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2094228T3 (es) * 1990-07-24 1997-01-16 Merrell Pharma Inc Peptidos anticoagulantes.
FR2667071A1 (fr) * 1990-09-26 1992-03-27 Adir Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2686086A1 (fr) * 1992-01-15 1993-07-16 Adir Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
HUT73187A (en) * 1993-06-11 1996-06-28 Merrell Pharma Inc Trifunctional antithrombin and antiplatelet peptides
US5972648A (en) * 1993-09-28 1999-10-26 Japan Energy Corporation Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients
WO2004113386A2 (en) * 2003-06-26 2004-12-29 Merck Patent Gmbh Modified hirudin proteins and t-cell epitopes in hirudin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
EP0333356A3 (en) * 1988-03-04 1990-12-19 Biogen, Inc. Hirudin peptides
FR2628429B1 (fr) * 1988-03-08 1990-12-28 Transgene Sa Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
AU630132B2 (en) * 1988-12-07 1992-10-22 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
ZA907743B (en) * 1989-10-03 1991-07-31 Merrell Dow Pharma Radiolabeled anticoagulant peptides
ZA907742B (en) * 1989-10-03 1991-07-31 Merrell Dow Pharma Anticoagulant peptides

Also Published As

Publication number Publication date
EP0468448B1 (en) 1996-06-12
DE69120158D1 (de) 1996-07-18
IE72961B1 (en) 1997-05-07
DE69120158T2 (de) 1996-10-31
JPH04234327A (ja) 1992-08-24
EP0468448A2 (en) 1992-01-29
ZA915658B (en) 1992-05-27
EP0468448A3 (en) 1992-04-08
TW209171B (https=) 1993-07-11
AU8111091A (en) 1992-01-30
IE912590A1 (en) 1992-01-29
ATE139121T1 (de) 1996-06-15
KR930001927A (ko) 1993-02-22
AU640502B2 (en) 1993-08-26
JP3264283B2 (ja) 2002-03-11
ES2090181T3 (es) 1996-10-16

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