DE69120158D1 - Hirudin-Analoge mit Antiblutplättchen-Aktivität - Google Patents
Hirudin-Analoge mit Antiblutplättchen-AktivitätInfo
- Publication number
- DE69120158D1 DE69120158D1 DE69120158T DE69120158T DE69120158D1 DE 69120158 D1 DE69120158 D1 DE 69120158D1 DE 69120158 T DE69120158 T DE 69120158T DE 69120158 T DE69120158 T DE 69120158T DE 69120158 D1 DE69120158 D1 DE 69120158D1
- Authority
- DE
- Germany
- Prior art keywords
- platelet activity
- hirudin analogues
- hirudin
- analogues
- platelet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Corsets Or Brassieres (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55728990A | 1990-07-24 | 1990-07-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69120158D1 true DE69120158D1 (de) | 1996-07-18 |
DE69120158T2 DE69120158T2 (de) | 1996-10-31 |
Family
ID=24224808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69120158T Expired - Fee Related DE69120158T2 (de) | 1990-07-24 | 1991-07-23 | Hirudin-Analoge mit Antiblutplättchen-Aktivität |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0468448B1 (de) |
JP (1) | JP3264283B2 (de) |
KR (1) | KR100200463B1 (de) |
AT (1) | ATE139121T1 (de) |
AU (1) | AU640502B2 (de) |
DE (1) | DE69120158T2 (de) |
ES (1) | ES2090181T3 (de) |
IE (1) | IE72961B1 (de) |
TW (1) | TW209171B (de) |
ZA (1) | ZA915658B (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUT63180A (en) * | 1990-07-24 | 1993-07-28 | Merrell Dow Pharma | Process for producing anticoagulant peptides |
FR2667071A1 (fr) * | 1990-09-26 | 1992-03-27 | Adir | Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2686086A1 (fr) * | 1992-01-15 | 1993-07-16 | Adir | Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
WO1994029349A1 (en) * | 1993-06-11 | 1994-12-22 | Merrell Pharmaceuticals Inc. | Trifunctional antithrombin and antiplatelet peptides |
US5972648A (en) * | 1993-09-28 | 1999-10-26 | Japan Energy Corporation | Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients |
EP1636267A2 (de) * | 2003-06-26 | 2006-03-22 | MERCK PATENT GmbH | Modifizierte hirudinproteine und t-zellen-epitope in hirudin |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1341032C (en) * | 1987-01-23 | 2000-06-20 | John L. Krstenansky | Anticoagulant peptides |
EP0333356A3 (de) * | 1988-03-04 | 1990-12-19 | Biogen, Inc. | Hirudin-Peptide |
FR2628429B1 (fr) * | 1988-03-08 | 1990-12-28 | Transgene Sa | Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir |
NZ228995A (en) * | 1988-05-10 | 1992-03-26 | Merrell Dow Pharma | Hirudin peptide derivatives and pharmaceutical compositions |
AU630132B2 (en) * | 1988-12-07 | 1992-10-22 | Merrell Dow Pharmaceuticals Inc. | Anticoagulant peptides |
ZA907742B (en) * | 1989-10-03 | 1991-07-31 | Merrell Dow Pharma | Anticoagulant peptides |
ZA907743B (en) * | 1989-10-03 | 1991-07-31 | Merrell Dow Pharma | Radiolabeled anticoagulant peptides |
-
1991
- 1991-07-18 AU AU81110/91A patent/AU640502B2/en not_active Ceased
- 1991-07-18 ZA ZA915658A patent/ZA915658B/xx unknown
- 1991-07-20 TW TW080105647A patent/TW209171B/zh active
- 1991-07-23 AT AT91112331T patent/ATE139121T1/de not_active IP Right Cessation
- 1991-07-23 EP EP91112331A patent/EP0468448B1/de not_active Expired - Lifetime
- 1991-07-23 IE IE259091A patent/IE72961B1/en not_active IP Right Cessation
- 1991-07-23 KR KR1019910012636A patent/KR100200463B1/ko not_active IP Right Cessation
- 1991-07-23 DE DE69120158T patent/DE69120158T2/de not_active Expired - Fee Related
- 1991-07-23 ES ES91112331T patent/ES2090181T3/es not_active Expired - Lifetime
- 1991-07-24 JP JP20624191A patent/JP3264283B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
TW209171B (de) | 1993-07-11 |
KR930001927A (ko) | 1993-02-22 |
AU640502B2 (en) | 1993-08-26 |
AU8111091A (en) | 1992-01-30 |
EP0468448A3 (en) | 1992-04-08 |
IE72961B1 (en) | 1997-05-07 |
ZA915658B (en) | 1992-05-27 |
DE69120158T2 (de) | 1996-10-31 |
EP0468448B1 (de) | 1996-06-12 |
ATE139121T1 (de) | 1996-06-15 |
ES2090181T3 (es) | 1996-10-16 |
KR100200463B1 (ko) | 1999-06-15 |
IE912590A1 (en) | 1992-01-29 |
JP3264283B2 (ja) | 2002-03-11 |
EP0468448A2 (de) | 1992-01-29 |
JPH04234327A (ja) | 1992-08-24 |
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DE69021000D1 (de) | Radiomarkierte Peptide mit Antikoagulanswirkung. | |
FI904852A0 (fi) | Antikoagulantpeptider. | |
DE68916850D1 (de) | Antikoagulierende Peptid-Alkohole. | |
DE69120158D1 (de) | Hirudin-Analoge mit Antiblutplättchen-Aktivität | |
DK614489D0 (da) | Peptidderivater | |
ATE219102T1 (de) | Stabilisierte sulfonat- und sulfatderivate von hirudin | |
FI930265A0 (fi) | Antikoagulantpeptider |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |