DE69120158D1 - Hirudin-Analoge mit Antiblutplättchen-Aktivität - Google Patents

Hirudin-Analoge mit Antiblutplättchen-Aktivität

Info

Publication number
DE69120158D1
DE69120158D1 DE69120158T DE69120158T DE69120158D1 DE 69120158 D1 DE69120158 D1 DE 69120158D1 DE 69120158 T DE69120158 T DE 69120158T DE 69120158 T DE69120158 T DE 69120158T DE 69120158 D1 DE69120158 D1 DE 69120158D1
Authority
DE
Germany
Prior art keywords
platelet activity
hirudin analogues
hirudin
analogues
platelet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69120158T
Other languages
English (en)
Other versions
DE69120158T2 (de
Inventor
John L Krstenansky
Robert J Broersma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69120158D1 publication Critical patent/DE69120158D1/de
Publication of DE69120158T2 publication Critical patent/DE69120158T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • External Artificial Organs (AREA)
  • Corsets Or Brassieres (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69120158T 1990-07-24 1991-07-23 Hirudin-Analoge mit Antiblutplättchen-Aktivität Expired - Fee Related DE69120158T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55728990A 1990-07-24 1990-07-24

Publications (2)

Publication Number Publication Date
DE69120158D1 true DE69120158D1 (de) 1996-07-18
DE69120158T2 DE69120158T2 (de) 1996-10-31

Family

ID=24224808

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69120158T Expired - Fee Related DE69120158T2 (de) 1990-07-24 1991-07-23 Hirudin-Analoge mit Antiblutplättchen-Aktivität

Country Status (10)

Country Link
EP (1) EP0468448B1 (de)
JP (1) JP3264283B2 (de)
KR (1) KR100200463B1 (de)
AT (1) ATE139121T1 (de)
AU (1) AU640502B2 (de)
DE (1) DE69120158T2 (de)
ES (1) ES2090181T3 (de)
IE (1) IE72961B1 (de)
TW (1) TW209171B (de)
ZA (1) ZA915658B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT63180A (en) * 1990-07-24 1993-07-28 Merrell Dow Pharma Process for producing anticoagulant peptides
FR2667071A1 (fr) * 1990-09-26 1992-03-27 Adir Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2686086A1 (fr) * 1992-01-15 1993-07-16 Adir Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ES2199963T3 (es) * 1993-06-11 2004-03-01 Merrell Pharmaceuticals Inc. Peptidos trifuncionales antitrombina y antiplaquetarios.
US5972648A (en) * 1993-09-28 1999-10-26 Japan Energy Corporation Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients
WO2004113386A2 (en) * 2003-06-26 2004-12-29 Merck Patent Gmbh Modified hirudin proteins and t-cell epitopes in hirudin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
AU3098289A (en) * 1988-03-04 1989-09-07 Biogen, Inc. Hirudin peptides
FR2628429B1 (fr) * 1988-03-08 1990-12-28 Transgene Sa Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
ZA899247B (en) * 1988-12-07 1990-09-26 Merrell Dow Pharma Anticoagulant peptides
CA2026376C (en) * 1989-10-03 2002-01-01 John L. Krstenansky Anticoagulant peptides
ZA907743B (en) * 1989-10-03 1991-07-31 Merrell Dow Pharma Radiolabeled anticoagulant peptides

Also Published As

Publication number Publication date
JPH04234327A (ja) 1992-08-24
IE912590A1 (en) 1992-01-29
AU8111091A (en) 1992-01-30
KR100200463B1 (ko) 1999-06-15
ATE139121T1 (de) 1996-06-15
DE69120158T2 (de) 1996-10-31
IE72961B1 (en) 1997-05-07
EP0468448B1 (de) 1996-06-12
ES2090181T3 (es) 1996-10-16
KR930001927A (ko) 1993-02-22
JP3264283B2 (ja) 2002-03-11
EP0468448A3 (en) 1992-04-08
AU640502B2 (en) 1993-08-26
EP0468448A2 (de) 1992-01-29
ZA915658B (en) 1992-05-27
TW209171B (de) 1993-07-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee