ATE219102T1 - Stabilisierte sulfonat- und sulfatderivate von hirudin - Google Patents

Stabilisierte sulfonat- und sulfatderivate von hirudin

Info

Publication number
ATE219102T1
ATE219102T1 AT91102011T AT91102011T ATE219102T1 AT E219102 T1 ATE219102 T1 AT E219102T1 AT 91102011 T AT91102011 T AT 91102011T AT 91102011 T AT91102011 T AT 91102011T AT E219102 T1 ATE219102 T1 AT E219102T1
Authority
AT
Austria
Prior art keywords
hirudin
sulfonate
stabilized
sulfate derivatives
derivatives
Prior art date
Application number
AT91102011T
Other languages
English (en)
Inventor
John L Krstenansky
Simon J T Mao
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE219102T1 publication Critical patent/ATE219102T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Detergent Compositions (AREA)
AT91102011T 1990-02-13 1991-02-13 Stabilisierte sulfonat- und sulfatderivate von hirudin ATE219102T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47931790A 1990-02-13 1990-02-13

Publications (1)

Publication Number Publication Date
ATE219102T1 true ATE219102T1 (de) 2002-06-15

Family

ID=23903519

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91102011T ATE219102T1 (de) 1990-02-13 1991-02-13 Stabilisierte sulfonat- und sulfatderivate von hirudin

Country Status (10)

Country Link
US (1) US5541161A (de)
EP (1) EP0443429B1 (de)
JP (1) JP2899430B2 (de)
AT (1) ATE219102T1 (de)
AU (1) AU641215B2 (de)
CA (1) CA2035917C (de)
DE (1) DE69133033T2 (de)
DK (1) DK0443429T3 (de)
ES (1) ES2174819T3 (de)
IE (1) IE910469A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005071A (en) * 1987-01-23 1999-12-21 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US5789540A (en) * 1987-01-23 1998-08-04 Merrell Pharmaceuticals Inc. Anticoagulant peptides
DE4103649A1 (de) * 1991-02-07 1992-08-13 Basf Ag Neue antikoagulatorisch wirksame peptide
ATE142642T1 (de) * 1991-03-05 1996-09-15 Japan Energy Corp Hirudinanalog oder dessen salz, dessen herstellung und das als aktiven bestandteil enthaltende antikoagulanz
RU2180218C2 (ru) 1997-01-20 2002-03-10 Джапэн Энерджи Корпорейшн Способ стабилизации гирудина и/или вариантов гирудина, лиофилизированная фармацевтическая композиция, полученная с применением данного способа
US7550425B2 (en) * 2000-06-16 2009-06-23 Zealand Pharma A/S Diuretic peptide conjugates
DE60225274T2 (de) 2001-05-21 2009-03-26 F. Hoffmann-La Roche Ag Chinolinderivate als liganden für den neuropeptid-y-rezeptor
US20050154011A1 (en) * 2003-02-20 2005-07-14 The Procter & Gamble Company Tetrahydroisoquinolnyl sulfamic acids
WO2006045503A1 (en) 2004-10-19 2006-05-04 Lonza Ag Method for solid phase peptide synthesis
PL3464336T3 (pl) 2016-06-01 2022-05-16 Athira Pharma, Inc. Związki

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
ZA883443B (en) * 1987-05-21 1988-11-16 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
CA1328540C (en) * 1987-05-21 1994-04-12 John L. Krstenansky Cyclic anticoagulant peptides
AU3098289A (en) * 1988-03-04 1989-09-07 Biogen, Inc. Hirudin peptides
EP0347376B1 (de) * 1988-06-11 1994-03-23 Ciba-Geigy Ag Polypeptide mit einer die Koagulierung hemmenden Wirkung

Also Published As

Publication number Publication date
DK0443429T3 (da) 2002-09-30
IE910469A1 (en) 1991-08-14
CA2035917A1 (en) 1991-08-14
AU7089091A (en) 1991-08-15
DE69133033T2 (de) 2003-02-06
US5541161A (en) 1996-07-30
EP0443429A1 (de) 1991-08-28
ES2174819T3 (es) 2002-11-16
JPH04211097A (ja) 1992-08-03
AU641215B2 (en) 1993-09-16
EP0443429B1 (de) 2002-06-12
JP2899430B2 (ja) 1999-06-02
DE69133033D1 (de) 2002-07-18
CA2035917C (en) 2001-10-02

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee