DK0443429T3 - Stabiliserede sulfonater og sulfater af hirudin - Google Patents

Stabiliserede sulfonater og sulfater af hirudin

Info

Publication number
DK0443429T3
DK0443429T3 DK91102011T DK91102011T DK0443429T3 DK 0443429 T3 DK0443429 T3 DK 0443429T3 DK 91102011 T DK91102011 T DK 91102011T DK 91102011 T DK91102011 T DK 91102011T DK 0443429 T3 DK0443429 T3 DK 0443429T3
Authority
DK
Denmark
Prior art keywords
hirudin
sulfonates
sulfates
stabilized
relates
Prior art date
Application number
DK91102011T
Other languages
Danish (da)
English (en)
Inventor
John L Krstenansky
Simon J T Mao
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0443429T3 publication Critical patent/DK0443429T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Detergent Compositions (AREA)
DK91102011T 1990-02-13 1991-02-13 Stabiliserede sulfonater og sulfater af hirudin DK0443429T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47931790A 1990-02-13 1990-02-13

Publications (1)

Publication Number Publication Date
DK0443429T3 true DK0443429T3 (da) 2002-09-30

Family

ID=23903519

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91102011T DK0443429T3 (da) 1990-02-13 1991-02-13 Stabiliserede sulfonater og sulfater af hirudin

Country Status (10)

Country Link
US (1) US5541161A (de)
EP (1) EP0443429B1 (de)
JP (1) JP2899430B2 (de)
AT (1) ATE219102T1 (de)
AU (1) AU641215B2 (de)
CA (1) CA2035917C (de)
DE (1) DE69133033T2 (de)
DK (1) DK0443429T3 (de)
ES (1) ES2174819T3 (de)
IE (1) IE910469A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789540A (en) * 1987-01-23 1998-08-04 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US6005071A (en) * 1987-01-23 1999-12-21 Merrell Pharmaceuticals Inc. Anticoagulant peptides
DE4103649A1 (de) * 1991-02-07 1992-08-13 Basf Ag Neue antikoagulatorisch wirksame peptide
WO1992015610A1 (fr) * 1991-03-05 1992-09-17 Nippon Mining Company Limited Analogue d'hirudine ou sel de ce compose, sa production, et anticoagulant le contenant en tant qu'ingredient actif
EP0998942A4 (de) 1997-01-20 2006-08-16 Japan Energy Corp Verfahren zur stabilisierung von peptiden und gefriergetrochnete medizinische zusammensetzungen mit diesen
US7550425B2 (en) * 2000-06-16 2009-06-23 Zealand Pharma A/S Diuretic peptide conjugates
EP1395564B1 (de) 2001-05-21 2008-02-27 F. Hoffmann-La Roche Ag Chinolinderivate als liganden für den neuropeptid-y-rezeptor
US20040167183A1 (en) * 2003-02-20 2004-08-26 The Procter & Gamble Company Phenethylamino sulfamic acids
EP1737889B1 (de) 2004-10-19 2010-09-08 Lonza AG Verfahren zur festphasen-peptidsynthese
WO2017210489A1 (en) 2016-06-01 2017-12-07 M3 Biotechnology, Inc. Compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
EP0209061B1 (de) * 1985-07-17 1994-01-12 Hoechst Aktiengesellschaft Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
ZA883443B (en) * 1987-05-21 1988-11-16 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
CA1328540C (en) * 1987-05-21 1994-04-12 John L. Krstenansky Cyclic anticoagulant peptides
AU3098289A (en) * 1988-03-04 1989-09-07 Biogen, Inc. Hirudin peptides
ES2052062T3 (es) * 1988-06-11 1994-07-01 Ciba Geigy Ag Nuevos polipeptidos con actividad anticoagulante.

Also Published As

Publication number Publication date
EP0443429B1 (de) 2002-06-12
DE69133033D1 (de) 2002-07-18
ATE219102T1 (de) 2002-06-15
DE69133033T2 (de) 2003-02-06
CA2035917A1 (en) 1991-08-14
AU7089091A (en) 1991-08-15
EP0443429A1 (de) 1991-08-28
ES2174819T3 (es) 2002-11-16
JPH04211097A (ja) 1992-08-03
US5541161A (en) 1996-07-30
AU641215B2 (en) 1993-09-16
IE910469A1 (en) 1991-08-14
JP2899430B2 (ja) 1999-06-02
CA2035917C (en) 2001-10-02

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