KR100197382B1 - 신규 알파-만노시다제 및 푸코시다제 억제제 - Google Patents

신규 알파-만노시다제 및 푸코시다제 억제제 Download PDF

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Publication number
KR100197382B1
KR100197382B1 KR1019910005783A KR910005783A KR100197382B1 KR 100197382 B1 KR100197382 B1 KR 100197382B1 KR 1019910005783 A KR1019910005783 A KR 1019910005783A KR 910005783 A KR910005783 A KR 910005783A KR 100197382 B1 KR100197382 B1 KR 100197382B1
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KR
South Korea
Prior art keywords
group
compound
formula
acid
hydroxymethyl
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Expired - Fee Related
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KR1019910005783A
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English (en)
Korean (ko)
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KR910018341A (ko
Inventor
에이.파르 로버트
피.피이트 노튼
Original Assignee
슈테펜엘.네스비트
메렐 다우 파마슈티칼스 인크.
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Publication of KR910018341A publication Critical patent/KR910018341A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
KR1019910005783A 1990-04-12 1991-04-11 신규 알파-만노시다제 및 푸코시다제 억제제 Expired - Fee Related KR100197382B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50887590A 1990-04-12 1990-04-12
US508875 1990-04-12

Publications (2)

Publication Number Publication Date
KR910018341A KR910018341A (ko) 1991-11-30
KR100197382B1 true KR100197382B1 (ko) 1999-06-15

Family

ID=24024437

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910005783A Expired - Fee Related KR100197382B1 (ko) 1990-04-12 1991-04-11 신규 알파-만노시다제 및 푸코시다제 억제제

Country Status (19)

Country Link
EP (1) EP0451834B1 (enExample)
JP (1) JP2955057B2 (enExample)
KR (1) KR100197382B1 (enExample)
CN (1) CN1033638C (enExample)
AT (1) ATE140692T1 (enExample)
AU (1) AU646855B2 (enExample)
CA (1) CA2040058C (enExample)
DE (1) DE69121000T2 (enExample)
DK (1) DK0451834T3 (enExample)
ES (1) ES2092520T3 (enExample)
FI (1) FI109200B (enExample)
GR (1) GR3020934T3 (enExample)
HU (1) HU213396B (enExample)
IE (1) IE75195B1 (enExample)
IL (1) IL97814A (enExample)
NO (1) NO175856C (enExample)
NZ (1) NZ237734A (enExample)
PT (1) PT97339B (enExample)
ZA (1) ZA912588B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773239A (en) * 1993-10-19 1998-06-30 Mount Sinai Hospital Corporation. Mannosidase inhibitors, process for their preparation and their use as therapeutic agents
US5650413A (en) * 1995-06-07 1997-07-22 Glycodesign Inc. Derivatives of swainsonine, processes for their preparation and their use as therapeutic agents
CN1251588A (zh) * 1996-10-01 2000-04-26 格里科设计公司 新的苦马豆素的3,5和/或6取代的类似物、制备其的方法及作为治疗剂的应用
US6395745B1 (en) 1997-04-15 2002-05-28 Glycodesign, Inc. Alkaloid halide salts of swainsonine and methods of use
US6051711A (en) * 1997-10-24 2000-04-18 Glycodesign Inc. Synthesis of swainsonine salts
WO2011094536A1 (en) * 2010-01-28 2011-08-04 Raptor Pharmaceuticalls Inc. Method for treating liver disorders with receptor associated protein ( irp) peptide-fucosidase inhibitor conjugates
CN101870992A (zh) * 2010-06-21 2010-10-27 天津科技大学 利用基因工程菌耦合发酵合成gdp-岩藻糖的方法
CN102286608B (zh) * 2011-06-08 2014-06-25 郑州安图生物工程股份有限公司 衣原体诊断方法和试剂盒

Also Published As

Publication number Publication date
NO175856C (no) 1994-12-21
IE75195B1 (en) 1997-08-27
IE911229A1 (en) 1991-10-23
NO175856B (enExample) 1994-09-12
EP0451834A3 (en) 1993-10-20
CA2040058A1 (en) 1991-10-13
IL97814A (en) 1995-08-31
ZA912588B (en) 1992-01-29
CN1055732A (zh) 1991-10-30
FI911751A0 (fi) 1991-04-11
PT97339B (pt) 1998-08-31
JP2955057B2 (ja) 1999-10-04
CN1033638C (zh) 1996-12-25
NO911419D0 (no) 1991-04-11
NO911419L (no) 1991-10-14
FI911751L (fi) 1991-10-13
FI109200B (fi) 2002-06-14
HUT60994A (en) 1992-11-30
EP0451834B1 (en) 1996-07-24
DE69121000T2 (de) 1996-12-19
CA2040058C (en) 2001-10-23
DE69121000D1 (de) 1996-08-29
AU7416491A (en) 1991-10-17
ES2092520T3 (es) 1996-12-01
HU213396B (en) 1997-06-30
AU646855B2 (en) 1994-03-10
GR3020934T3 (en) 1996-12-31
IL97814A0 (en) 1992-06-21
PT97339A (pt) 1992-01-31
KR910018341A (ko) 1991-11-30
HU911196D0 (en) 1991-10-28
JPH04234834A (ja) 1992-08-24
NZ237734A (en) 1993-05-26
EP0451834A2 (en) 1991-10-16
DK0451834T3 (da) 1996-08-26
ATE140692T1 (de) 1996-08-15

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