ATE140692T1 - Alpha-mannosidase- und fucosidase-hemmer - Google Patents

Alpha-mannosidase- und fucosidase-hemmer

Info

Publication number
ATE140692T1
ATE140692T1 AT91105766T AT91105766T ATE140692T1 AT E140692 T1 ATE140692 T1 AT E140692T1 AT 91105766 T AT91105766 T AT 91105766T AT 91105766 T AT91105766 T AT 91105766T AT E140692 T1 ATE140692 T1 AT E140692T1
Authority
AT
Austria
Prior art keywords
alpha
mannosidase
fucosidase inhibitors
beta
fucosidase
Prior art date
Application number
AT91105766T
Other languages
English (en)
Inventor
Robert A Farr
Norton P Peet
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE140692T1 publication Critical patent/ATE140692T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
AT91105766T 1990-04-12 1991-04-11 Alpha-mannosidase- und fucosidase-hemmer ATE140692T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50887590A 1990-04-12 1990-04-12

Publications (1)

Publication Number Publication Date
ATE140692T1 true ATE140692T1 (de) 1996-08-15

Family

ID=24024437

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91105766T ATE140692T1 (de) 1990-04-12 1991-04-11 Alpha-mannosidase- und fucosidase-hemmer

Country Status (19)

Country Link
EP (1) EP0451834B1 (de)
JP (1) JP2955057B2 (de)
KR (1) KR100197382B1 (de)
CN (1) CN1033638C (de)
AT (1) ATE140692T1 (de)
AU (1) AU646855B2 (de)
CA (1) CA2040058C (de)
DE (1) DE69121000T2 (de)
DK (1) DK0451834T3 (de)
ES (1) ES2092520T3 (de)
FI (1) FI109200B (de)
GR (1) GR3020934T3 (de)
HU (1) HU213396B (de)
IE (1) IE75195B1 (de)
IL (1) IL97814A (de)
NO (1) NO175856C (de)
NZ (1) NZ237734A (de)
PT (1) PT97339B (de)
ZA (1) ZA912588B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773239A (en) * 1993-10-19 1998-06-30 Mount Sinai Hospital Corporation. Mannosidase inhibitors, process for their preparation and their use as therapeutic agents
US5650413A (en) * 1995-06-07 1997-07-22 Glycodesign Inc. Derivatives of swainsonine, processes for their preparation and their use as therapeutic agents
WO1998014446A1 (en) * 1996-10-01 1998-04-09 Glycodesign Inc. Novel 3, 5, and/or 6 substituted analogues of swainsonine, processes for their preparation and their use as therapeutic agents
CA2286766A1 (en) 1997-04-15 1998-10-22 Glycodesign Inc. Alkaloid halide salts of swainsonine and methods of use
AU9617298A (en) * 1997-10-24 1999-05-17 Glycodesign Inc. Synthesis of swainsonine salts
ES2555555T3 (es) * 2010-01-28 2016-01-04 Raptor Pharmaceuticals Inc. Conjugados de péptido de proteína asociada al receptor inhibidor de fucosidasa y su uso en el tratamiento de tumores hepáticos
CN101870992A (zh) * 2010-06-21 2010-10-27 天津科技大学 利用基因工程菌耦合发酵合成gdp-岩藻糖的方法
CN102286608B (zh) * 2011-06-08 2014-06-25 郑州安图生物工程股份有限公司 衣原体诊断方法和试剂盒

Also Published As

Publication number Publication date
CA2040058C (en) 2001-10-23
IE75195B1 (en) 1997-08-27
EP0451834A2 (de) 1991-10-16
AU7416491A (en) 1991-10-17
FI109200B (fi) 2002-06-14
GR3020934T3 (en) 1996-12-31
NZ237734A (en) 1993-05-26
PT97339B (pt) 1998-08-31
HU911196D0 (en) 1991-10-28
FI911751A0 (fi) 1991-04-11
CN1055732A (zh) 1991-10-30
DE69121000D1 (de) 1996-08-29
IL97814A (en) 1995-08-31
EP0451834B1 (de) 1996-07-24
NO911419L (no) 1991-10-14
JP2955057B2 (ja) 1999-10-04
KR100197382B1 (ko) 1999-06-15
IL97814A0 (en) 1992-06-21
ES2092520T3 (es) 1996-12-01
HU213396B (en) 1997-06-30
IE911229A1 (en) 1991-10-23
AU646855B2 (en) 1994-03-10
DE69121000T2 (de) 1996-12-19
CA2040058A1 (en) 1991-10-13
EP0451834A3 (en) 1993-10-20
NO911419D0 (no) 1991-04-11
NO175856B (de) 1994-09-12
PT97339A (pt) 1992-01-31
NO175856C (no) 1994-12-21
KR910018341A (ko) 1991-11-30
CN1033638C (zh) 1996-12-25
HUT60994A (en) 1992-11-30
DK0451834T3 (da) 1996-08-26
JPH04234834A (ja) 1992-08-24
FI911751A (fi) 1991-10-13
ZA912588B (en) 1992-01-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee