KR100197382B1 - 신규 알파-만노시다제 및 푸코시다제 억제제 - Google Patents

신규 알파-만노시다제 및 푸코시다제 억제제 Download PDF

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Publication number
KR100197382B1
KR100197382B1 KR1019910005783A KR910005783A KR100197382B1 KR 100197382 B1 KR100197382 B1 KR 100197382B1 KR 1019910005783 A KR1019910005783 A KR 1019910005783A KR 910005783 A KR910005783 A KR 910005783A KR 100197382 B1 KR100197382 B1 KR 100197382B1
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KR
South Korea
Prior art keywords
group
compound
formula
acid
hydroxymethyl
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Expired - Fee Related
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KR1019910005783A
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English (en)
Korean (ko)
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KR910018341A (ko
Inventor
에이.파르 로버트
피.피이트 노튼
Original Assignee
슈테펜엘.네스비트
메렐 다우 파마슈티칼스 인크.
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Publication of KR910018341A publication Critical patent/KR910018341A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
KR1019910005783A 1990-04-12 1991-04-11 신규 알파-만노시다제 및 푸코시다제 억제제 Expired - Fee Related KR100197382B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50887590A 1990-04-12 1990-04-12
US508875 1990-04-12

Publications (2)

Publication Number Publication Date
KR910018341A KR910018341A (ko) 1991-11-30
KR100197382B1 true KR100197382B1 (ko) 1999-06-15

Family

ID=24024437

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910005783A Expired - Fee Related KR100197382B1 (ko) 1990-04-12 1991-04-11 신규 알파-만노시다제 및 푸코시다제 억제제

Country Status (19)

Country Link
EP (1) EP0451834B1 (cg-RX-API-DMAC7.html)
JP (1) JP2955057B2 (cg-RX-API-DMAC7.html)
KR (1) KR100197382B1 (cg-RX-API-DMAC7.html)
CN (1) CN1033638C (cg-RX-API-DMAC7.html)
AT (1) ATE140692T1 (cg-RX-API-DMAC7.html)
AU (1) AU646855B2 (cg-RX-API-DMAC7.html)
CA (1) CA2040058C (cg-RX-API-DMAC7.html)
DE (1) DE69121000T2 (cg-RX-API-DMAC7.html)
DK (1) DK0451834T3 (cg-RX-API-DMAC7.html)
ES (1) ES2092520T3 (cg-RX-API-DMAC7.html)
FI (1) FI109200B (cg-RX-API-DMAC7.html)
GR (1) GR3020934T3 (cg-RX-API-DMAC7.html)
HU (1) HU213396B (cg-RX-API-DMAC7.html)
IE (1) IE75195B1 (cg-RX-API-DMAC7.html)
IL (1) IL97814A (cg-RX-API-DMAC7.html)
NO (1) NO175856C (cg-RX-API-DMAC7.html)
NZ (1) NZ237734A (cg-RX-API-DMAC7.html)
PT (1) PT97339B (cg-RX-API-DMAC7.html)
ZA (1) ZA912588B (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773239A (en) * 1993-10-19 1998-06-30 Mount Sinai Hospital Corporation. Mannosidase inhibitors, process for their preparation and their use as therapeutic agents
US5650413A (en) * 1995-06-07 1997-07-22 Glycodesign Inc. Derivatives of swainsonine, processes for their preparation and their use as therapeutic agents
US6048870A (en) * 1996-10-01 2000-04-11 Glycodesign 3, 5, and/or 6 substituted analogues of swainsonine processes for their preparation and their use as therapeutic agents
US6395745B1 (en) 1997-04-15 2002-05-28 Glycodesign, Inc. Alkaloid halide salts of swainsonine and methods of use
WO1999021858A1 (en) * 1997-10-24 1999-05-06 Glycodesign Inc. Synthesis of swainsonine salts
JP6170675B2 (ja) * 2010-01-28 2017-07-26 ラプトール ファーマシューティカルズ インコーポレイテッド 受容体関連タンパク質（ｒａｐ）ペプチド−フコシダーゼ阻害薬複合体による肝障害処置のための方法
CN101870992A (zh) * 2010-06-21 2010-10-27 天津科技大学 利用基因工程菌耦合发酵合成gdp-岩藻糖的方法
CN102286608B (zh) * 2011-06-08 2014-06-25 郑州安图生物工程股份有限公司 衣原体诊断方法和试剂盒

Also Published As

Publication number Publication date
PT97339B (pt) 1998-08-31
DE69121000T2 (de) 1996-12-19
PT97339A (pt) 1992-01-31
NZ237734A (en) 1993-05-26
CN1055732A (zh) 1991-10-30
AU7416491A (en) 1991-10-17
CN1033638C (zh) 1996-12-25
IL97814A0 (en) 1992-06-21
IE75195B1 (en) 1997-08-27
FI911751A0 (fi) 1991-04-11
CA2040058A1 (en) 1991-10-13
AU646855B2 (en) 1994-03-10
EP0451834B1 (en) 1996-07-24
NO175856B (cg-RX-API-DMAC7.html) 1994-09-12
DE69121000D1 (de) 1996-08-29
EP0451834A3 (en) 1993-10-20
NO911419D0 (no) 1991-04-11
JP2955057B2 (ja) 1999-10-04
NO175856C (no) 1994-12-21
KR910018341A (ko) 1991-11-30
NO911419L (no) 1991-10-14
ES2092520T3 (es) 1996-12-01
HU213396B (en) 1997-06-30
HU911196D0 (en) 1991-10-28
EP0451834A2 (en) 1991-10-16
IL97814A (en) 1995-08-31
FI911751L (fi) 1991-10-13
CA2040058C (en) 2001-10-23
JPH04234834A (ja) 1992-08-24
FI109200B (fi) 2002-06-14
GR3020934T3 (en) 1996-12-31
ATE140692T1 (de) 1996-08-15
DK0451834T3 (da) 1996-08-26
ZA912588B (en) 1992-01-29
HUT60994A (en) 1992-11-30
IE911229A1 (en) 1991-10-23

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