JPWO2023282245A5 - - Google Patents

Info

Publication number
JPWO2023282245A5
JPWO2023282245A5 JP2023533132A JP2023533132A JPWO2023282245A5 JP WO2023282245 A5 JPWO2023282245 A5 JP WO2023282245A5 JP 2023533132 A JP2023533132 A JP 2023533132A JP 2023533132 A JP2023533132 A JP 2023533132A JP WO2023282245 A5 JPWO2023282245 A5 JP WO2023282245A5
Authority
JP
Japan
Prior art keywords
group
hydrophobic
protecting group
nucleotide
nucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023533132A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2023282245A1 (https=
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/JP2022/026665 external-priority patent/WO2023282245A1/ja
Publication of JPWO2023282245A1 publication Critical patent/JPWO2023282245A1/ja
Publication of JPWO2023282245A5 publication Critical patent/JPWO2023282245A5/ja
Pending legal-status Critical Current

Links

JP2023533132A 2021-07-05 2022-07-05 Pending JPWO2023282245A1 (https=)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2021111420 2021-07-05
PCT/JP2022/026665 WO2023282245A1 (ja) 2021-07-05 2022-07-05 ヌクレオチド類の精製方法及びヌクレオチド類の精製装置並びに疎水性試薬及び疎水性基質

Publications (2)

Publication Number Publication Date
JPWO2023282245A1 JPWO2023282245A1 (https=) 2023-01-12
JPWO2023282245A5 true JPWO2023282245A5 (https=) 2026-02-09

Family

ID=84800657

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023533132A Pending JPWO2023282245A1 (https=) 2021-07-05 2022-07-05

Country Status (5)

Country Link
US (1) US20240327444A1 (https=)
EP (1) EP4368628A4 (https=)
JP (1) JPWO2023282245A1 (https=)
CN (1) CN117858885A (https=)
WO (1) WO2023282245A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024185697A1 (ja) * 2023-03-03 2024-09-12 国立大学法人東海国立大学機構 ポリヌクレオチド連結産物の製造方法
CN116478226B (zh) * 2023-03-07 2025-08-19 江苏申基生物科技有限公司 一种锁核苷帽类似物和应用
WO2025054401A2 (en) * 2023-09-06 2025-03-13 Trilink Biotechnologies, Llc Cap analogs and methods of use thereof
CN116875658B (zh) * 2023-09-09 2024-02-06 南京鸿明生物科技有限公司 一种脱氧核酶及检测mRNA加帽率的方法
WO2025141025A2 (en) * 2023-12-26 2025-07-03 Eleven Therapeutics Ltd Novel capping strategies for mrna 5'cap
WO2025187713A1 (en) * 2024-03-07 2025-09-12 Eisai R&D Management Co., Ltd. Polynucleotide and producing method thereof
WO2026009964A1 (ja) * 2024-07-05 2026-01-08 国立大学法人東海国立大学機構 キャップ化ポリヌクレオチド
EP4725949A1 (en) * 2024-10-08 2026-04-15 BioSpring Gesellschaft für Biotechnologie mbH Improved solid-phase phosphoramidite-synthesis of long oligonucleotide molecules

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3433649A1 (de) * 1984-09-13 1986-03-20 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verfahren zur aufreinigung synthetischer oligonucleotide
US5998604A (en) * 1997-09-15 1999-12-07 The Perkin-Elmer Corporation Polynucleotide purification method
US7345163B2 (en) * 2002-08-28 2008-03-18 Quiatech Ab Process for separating and deprotecting oligonucleotides
NZ590265A (en) 2008-06-11 2012-11-30 Lasergen Inc Nucleotides and nucleosides and methods for their use in dna sequencing
WO2013040257A1 (en) * 2011-09-13 2013-03-21 Lasergen, Inc. 5-methoxy. 3'-oh unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
CN102898464B (zh) * 2012-05-23 2015-04-01 北京大学 光敏感基团保护的功能基团亚磷酰胺及其制备方法和应用
US10428379B2 (en) * 2013-03-15 2019-10-01 Ibis Biosciences, Inc. Nucleotide analogs for sequencing
US10808242B2 (en) 2015-08-28 2020-10-20 Biontech Rna Pharmaceuticals Gmbh Method for reducing immunogenicity of RNA
CN120842296A (zh) 2015-09-21 2025-10-28 垂林克生物技术有限公司 用于合成5’-加帽rna的组合物和方法
EP3372610A1 (en) 2017-03-08 2018-09-12 ETH Zurich Novel phosphorylation reagents and uses thereof
JP7099190B2 (ja) 2018-08-30 2022-07-12 横浜ゴム株式会社 空気入りタイヤ
JP7551134B2 (ja) 2019-07-31 2024-09-17 国立研究開発法人科学技術振興機構 プライマー及びこれを用いた二本鎖dnaの製造装置並びに二本鎖dnaの製造方法

Similar Documents

Publication Publication Date Title
JPWO2023282245A5 (https=)
US6008400A (en) Orthoester reagents for use as protecting groups in oligonucleotide synthesis
JP3893057B2 (ja) 新規な核酸塩基対
JPH10501809A (ja) 分子内求核置換による公知および新規2′−ヌクレオシドの新規製造方法
HK1048639A1 (zh) 木-lna类似物
WO2011103468A2 (en) Phosphoramidites for synthetic rna in the reverse direction
WO1998022489A1 (en) Novel nucleotide analogues
PT98931B (pt) Processo para a ligacao de nucleosidos com uma ponte siloxano
US20120065387A1 (en) Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids
JP2005089441A (ja) 立体規則性の高いリン原子修飾ヌクレオチド類縁体の製造法
CN111344296A (zh) 含有胺掩蔽的部分的核苷酸衍生物及其在模板化和非模板化酶促核酸合成中的用途
JP2011088935A (ja) リン原子修飾ヌクレオチド類縁体の製造のための光学活性ヌクレオシド3’−ホスホロアミダイト
EP3137478A2 (en) Phosphorous protecting groups and methods of preparation and use thereof
JP5194256B2 (ja) 2’水酸基修飾リボヌクレオシド誘導体
KR20220160076A (ko) 3'-o-아미노-2'-데옥시리보뉴클레오사이드-5'-트라이포스페이트의 제조 방법
Apostle et al. Synthesis of Sensitive RNAs Using Fluoride‐Cleavable Groups as Linkers and Amino‐Group Protection
Saneyoshi et al. Chemical synthesis of RNA via 2′-O-cyanoethylated intermediates
JP3677510B2 (ja) 4’−チオヌクレオチド
Srivastava et al. Achiral, acyclic nucleic acids: synthesis and biophysical studies of a possible prebiotic polymer
JP6429264B2 (ja) ボラノホスフェート化合物、及び核酸オリゴマー
CA2599259A1 (en) Synthesis of oligonucleotides
Seela et al. 6-Azauracil or 8-aza-7-deazaadenine nucleosides and oligonucleotides: the effect of 2′-fluoro substituents and nucleobase nitrogens on conformation and base pairing
KR20220107246A (ko) 3'-rna 올리고뉴클레오타이드의 합성
WO2021080021A1 (ja) オリゴヌクレオチドを製造する方法
JP4015136B2 (ja) フェノール骨格を有するデオキシリボース誘導体および光応答性ヌクレオチド