JPWO2023237484A5 - - Google Patents
Info
- Publication number
- JPWO2023237484A5 JPWO2023237484A5 JP2024570947A JP2024570947A JPWO2023237484A5 JP WO2023237484 A5 JPWO2023237484 A5 JP WO2023237484A5 JP 2024570947 A JP2024570947 A JP 2024570947A JP 2024570947 A JP2024570947 A JP 2024570947A JP WO2023237484 A5 JPWO2023237484 A5 JP WO2023237484A5
- Authority
- JP
- Japan
- Prior art keywords
- methylene
- freeze
- tetrahydrofolic acid
- disodium salt
- citrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22177932 | 2022-06-08 | ||
| EP22177932.5 | 2022-06-08 | ||
| PCT/EP2023/064972 WO2023237484A1 (en) | 2022-06-08 | 2023-06-05 | Compositions comprising disodium 5,10-methylene-(6r)-tetrahydrofolate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2025518274A JP2025518274A (ja) | 2025-06-12 |
| JPWO2023237484A5 true JPWO2023237484A5 (https=) | 2025-12-18 |
| JP2025518274A5 JP2025518274A5 (https=) | 2025-12-18 |
Family
ID=81984853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024570947A Pending JP2025518274A (ja) | 2022-06-08 | 2023-06-05 | ５，１０－メチレン－（６ｒ）－テトラヒドロ葉酸二ナトリウムを含む組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20250360135A1 (https=) |
| EP (2) | EP4536187B1 (https=) |
| JP (1) | JP2025518274A (https=) |
| KR (1) | KR20250022145A (https=) |
| CN (1) | CN119365186A (https=) |
| AU (1) | AU2023282347A1 (https=) |
| CA (1) | CA3258734A1 (https=) |
| IL (1) | IL317395A (https=) |
| WO (1) | WO2023237484A1 (https=) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1215945A (en) | 1983-03-20 | 1986-12-30 | Bengt Gustavsson | Fluid transfer system |
| CH682664A5 (en) * | 1991-10-15 | 1993-10-29 | Eprova Ag | Stable salts of 5,10-methylene tetrahydrofolate. |
| CN1122456C (zh) * | 1996-01-31 | 2003-10-01 | 南亚拉巴马医学科学基金会 | 含有天然的还原叶酸盐异构体的食品和维生素制品 |
| CH696628A5 (de) * | 2002-02-26 | 2007-08-31 | Eprova Ag | Verwendung von Folaten zur Herstellung einer Zubereitung geeignet zur Vorbeugung und Behandlung von Entzündungen und entzündungsassoziierter Krankheiten, im Speziellen zur Beeinflussung der |
| CH697021A5 (de) * | 2003-06-26 | 2008-03-31 | Merck Eprova Ag | Stabile pharmazeutische Zusammensetzungen von 5, 10-Methylentetrahydrofolat. |
| EP1968551A2 (en) | 2005-12-02 | 2008-09-17 | Adventrx Pharmaceuticals, Inc. | Stable pharmaceutical compositions of 5,10 methylenetetrahydrofolate |
| JP6235779B2 (ja) * | 2012-03-28 | 2017-11-22 | 株式会社コーセー | 葉酸含有組成物及び葉酸の安定化方法 |
| EP2799061A1 (en) * | 2013-04-30 | 2014-11-05 | Aprofol AG | Stable high dose pharmaceutical composition containing folates |
| EP2837631A1 (en) * | 2013-08-14 | 2015-02-18 | Merck & Cie | New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid |
| US10059710B2 (en) * | 2016-02-17 | 2018-08-28 | Merck & Cie | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid |
| DK3668516T3 (da) | 2017-08-16 | 2021-12-13 | Merck Patent Gmbh | Stabile lyofilisater omfattende 5,10-methylen-(6r)-tetrahydrofolsyre og en dicarboxylsyre |
| CN107892692A (zh) * | 2017-12-28 | 2018-04-10 | 华东理工大学 | (6s)‑5‑甲基四氢叶酸锌盐的制备方法及其应用 |
-
2023
- 2023-06-05 US US18/872,672 patent/US20250360135A1/en active Pending
- 2023-06-05 CA CA3258734A patent/CA3258734A1/en active Pending
- 2023-06-05 EP EP23730517.2A patent/EP4536187B1/en active Active
- 2023-06-05 WO PCT/EP2023/064972 patent/WO2023237484A1/en not_active Ceased
- 2023-06-05 IL IL317395A patent/IL317395A/en unknown
- 2023-06-05 JP JP2024570947A patent/JP2025518274A/ja active Pending
- 2023-06-05 EP EP26153960.5A patent/EP4706775A2/en active Pending
- 2023-06-05 AU AU2023282347A patent/AU2023282347A1/en active Pending
- 2023-06-05 CN CN202380045351.1A patent/CN119365186A/zh active Pending
- 2023-06-05 KR KR1020257000562A patent/KR20250022145A/ko active Pending
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