JPWO2023178202A5 - - Google Patents

Info

Publication number
JPWO2023178202A5
JPWO2023178202A5 JP2024555107A JP2024555107A JPWO2023178202A5 JP WO2023178202 A5 JPWO2023178202 A5 JP WO2023178202A5 JP 2024555107 A JP2024555107 A JP 2024555107A JP 2024555107 A JP2024555107 A JP 2024555107A JP WO2023178202 A5 JPWO2023178202 A5 JP WO2023178202A5
Authority
JP
Japan
Prior art keywords
disease
alkyl
syndrome
compound according
bifunctional compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024555107A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025509730A5 (https=
JP2025509730A (ja
Publication date
Priority claimed from US17/695,645 external-priority patent/US12485178B2/en
Application filed filed Critical
Priority claimed from PCT/US2023/064470 external-priority patent/WO2023178202A2/en
Publication of JP2025509730A publication Critical patent/JP2025509730A/ja
Publication of JP2025509730A5 publication Critical patent/JP2025509730A5/ja
Publication of JPWO2023178202A5 publication Critical patent/JPWO2023178202A5/ja
Pending legal-status Critical Current

Links

JP2024555107A 2022-03-15 2023-03-15 循環タンパク質の選択的分解を目的とした二官能性小分子 Pending JP2025509730A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17/695,645 2022-03-15
US17/695,645 US12485178B2 (en) 2018-04-09 2022-03-15 Bifunctional small molecules to target the selective degradation of circulating proteins
PCT/US2023/064470 WO2023178202A2 (en) 2022-03-15 2023-03-15 Bifunctional small molecules to target the selective degradation of circulating proteins

Publications (3)

Publication Number Publication Date
JP2025509730A JP2025509730A (ja) 2025-04-11
JP2025509730A5 JP2025509730A5 (https=) 2026-03-24
JPWO2023178202A5 true JPWO2023178202A5 (https=) 2026-03-24

Family

ID=88024440

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024555107A Pending JP2025509730A (ja) 2022-03-15 2023-03-15 循環タンパク質の選択的分解を目的とした二官能性小分子

Country Status (8)

Country Link
EP (1) EP4493222A2 (https=)
JP (1) JP2025509730A (https=)
KR (1) KR20240166514A (https=)
CN (1) CN119255822A (https=)
AU (1) AU2023236291A1 (https=)
IL (1) IL315579A (https=)
MX (1) MX2024011338A (https=)
WO (1) WO2023178202A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022310356A1 (en) 2021-07-14 2024-01-25 Lycia Therapeutics, Inc. Asgpr cell surface receptor binding compounds and conjugates
WO2025219911A1 (en) * 2024-04-16 2025-10-23 Biohaven Therapeutics Ltd. Treatment of diseases with monoclonal antibody drugs and molecular degraders
WO2025248469A1 (en) * 2024-05-28 2025-12-04 Biohaven Therapeutics Ltd. TREATMENT OF IgG-RELATED DISEASES

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2997444A1 (en) * 2015-09-29 2017-04-06 Amgen Inc. Asgr inhibitors for reducing cholesterol levels
US12364766B2 (en) * 2018-04-09 2025-07-22 Yale University Bifunctional small molecules to target the selective degradation of circulating proteins
WO2019199621A1 (en) * 2018-04-09 2019-10-17 Yale University Bi-functional molecules to degrade circulating proteins
CN113301925A (zh) * 2018-12-19 2021-08-24 小利兰·斯坦福大学理事会 用于溶酶体靶向的双官能分子以及相关的组合物和方法
IL294515A (en) * 2020-01-31 2022-09-01 Avilar Therapeutics Inc Compounds bind asgpr to degrade extracellular proteins

Similar Documents

Publication Publication Date Title
WO2019199621A4 (en) Bi-functional molecules to degrade circulating proteins
JP2021521192A5 (https=)
JP6703583B2 (ja) 高活性抗新生物薬及び抗増殖剤
JP2023175957A5 (https=)
RU2018105094A (ru) Модуляторы протеолиза на основе аланина и связанные с ними способы применения
WO2019199634A4 (en) Bifunctional small molecules to target the selective degradation of circulating proteins
IL319363A (en) Cervalon ligands and bifunctional compounds containing them
JP2011515478A5 (https=)
JPWO2019199816A5 (https=)
RU2020139890A (ru) Имидные модуляторы протеолиза и способы их применения
JP2017513862A5 (https=)
JP2022526895A (ja) 有橋三環式カルバモイルピリドン化合物およびその薬学的使用
JP2021519337A (ja) Ikarosの分解のためのセレブロン結合剤
IL323835A (en) Bifunctional small molecules to target the selective degradation of circulating proteins
RU2017145267A (ru) Модуляторы протеолиза на основе имидов и связанные с ними способы применения
RU2014133019A (ru) Соединения и способы усиления деградации белков-мишеней и других полипептидов с помощью е3 убиквитин лигазы
JP2016519091A5 (https=)
JP2011519868A5 (https=)
EP3826675A1 (en) Nanoparticle compositions
JP2014516964A5 (https=)
JPWO2023178202A5 (https=)
JPWO2021055705A5 (https=)
WO2021146211A1 (en) Nanoparticle compositions
JPWO2023178179A5 (https=)
TW202342442A (zh) Raf激酶抑制劑及其使用方法