KR20240166514A - 순환하는 단백질의 선택적인 분해를 표적화하는 이작용성 소 분자 - Google Patents
순환하는 단백질의 선택적인 분해를 표적화하는 이작용성 소 분자 Download PDFInfo
- Publication number
- KR20240166514A KR20240166514A KR1020247034017A KR20247034017A KR20240166514A KR 20240166514 A KR20240166514 A KR 20240166514A KR 1020247034017 A KR1020247034017 A KR 1020247034017A KR 20247034017 A KR20247034017 A KR 20247034017A KR 20240166514 A KR20240166514 A KR 20240166514A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- disease
- group
- compound
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17/695,645 | 2022-03-15 | ||
| US17/695,645 US12485178B2 (en) | 2018-04-09 | 2022-03-15 | Bifunctional small molecules to target the selective degradation of circulating proteins |
| PCT/US2023/064470 WO2023178202A2 (en) | 2022-03-15 | 2023-03-15 | Bifunctional small molecules to target the selective degradation of circulating proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20240166514A true KR20240166514A (ko) | 2024-11-26 |
Family
ID=88024440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247034017A Pending KR20240166514A (ko) | 2022-03-15 | 2023-03-15 | 순환하는 단백질의 선택적인 분해를 표적화하는 이작용성 소 분자 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP4493222A2 (https=) |
| JP (1) | JP2025509730A (https=) |
| KR (1) | KR20240166514A (https=) |
| CN (1) | CN119255822A (https=) |
| AU (1) | AU2023236291A1 (https=) |
| IL (1) | IL315579A (https=) |
| MX (1) | MX2024011338A (https=) |
| WO (1) | WO2023178202A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2022310356A1 (en) | 2021-07-14 | 2024-01-25 | Lycia Therapeutics, Inc. | Asgpr cell surface receptor binding compounds and conjugates |
| WO2025219911A1 (en) * | 2024-04-16 | 2025-10-23 | Biohaven Therapeutics Ltd. | Treatment of diseases with monoclonal antibody drugs and molecular degraders |
| WO2025248469A1 (en) * | 2024-05-28 | 2025-12-04 | Biohaven Therapeutics Ltd. | TREATMENT OF IgG-RELATED DISEASES |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2997444A1 (en) * | 2015-09-29 | 2017-04-06 | Amgen Inc. | Asgr inhibitors for reducing cholesterol levels |
| US12364766B2 (en) * | 2018-04-09 | 2025-07-22 | Yale University | Bifunctional small molecules to target the selective degradation of circulating proteins |
| WO2019199621A1 (en) * | 2018-04-09 | 2019-10-17 | Yale University | Bi-functional molecules to degrade circulating proteins |
| CN113301925A (zh) * | 2018-12-19 | 2021-08-24 | 小利兰·斯坦福大学理事会 | 用于溶酶体靶向的双官能分子以及相关的组合物和方法 |
| IL294515A (en) * | 2020-01-31 | 2022-09-01 | Avilar Therapeutics Inc | Compounds bind asgpr to degrade extracellular proteins |
-
2023
- 2023-03-15 IL IL315579A patent/IL315579A/en unknown
- 2023-03-15 WO PCT/US2023/064470 patent/WO2023178202A2/en not_active Ceased
- 2023-03-15 AU AU2023236291A patent/AU2023236291A1/en active Pending
- 2023-03-15 CN CN202380040388.5A patent/CN119255822A/zh active Pending
- 2023-03-15 KR KR1020247034017A patent/KR20240166514A/ko active Pending
- 2023-03-15 JP JP2024555107A patent/JP2025509730A/ja active Pending
- 2023-03-15 EP EP23771648.5A patent/EP4493222A2/en active Pending
-
2024
- 2024-09-13 MX MX2024011338A patent/MX2024011338A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2025509730A (ja) | 2025-04-11 |
| EP4493222A2 (en) | 2025-01-22 |
| MX2024011338A (es) | 2024-12-06 |
| AU2023236291A1 (en) | 2024-10-03 |
| CN119255822A (zh) | 2025-01-03 |
| WO2023178202A2 (en) | 2023-09-21 |
| IL315579A (en) | 2024-11-01 |
| WO2023178202A3 (en) | 2023-10-26 |
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| KR20240166514A (ko) | 순환하는 단백질의 선택적인 분해를 표적화하는 이작용성 소 분자 | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |