JP2025509730A5 - - Google Patents

Info

Publication number
JP2025509730A5
JP2025509730A5 JP2024555107A JP2024555107A JP2025509730A5 JP 2025509730 A5 JP2025509730 A5 JP 2025509730A5 JP 2024555107 A JP2024555107 A JP 2024555107A JP 2024555107 A JP2024555107 A JP 2024555107A JP 2025509730 A5 JP2025509730 A5 JP 2025509730A5
Authority
JP
Japan
Prior art keywords
disease
alkyl
syndrome
compound according
bifunctional compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024555107A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025509730A (ja
Filing date
Publication date
Priority claimed from US17/695,645 external-priority patent/US12485178B2/en
Application filed filed Critical
Priority claimed from PCT/US2023/064470 external-priority patent/WO2023178202A2/en
Publication of JP2025509730A publication Critical patent/JP2025509730A/ja
Publication of JP2025509730A5 publication Critical patent/JP2025509730A5/ja
Pending legal-status Critical Current

Links

JP2024555107A 2022-03-15 2023-03-15 循環タンパク質の選択的分解を目的とした二官能性小分子 Pending JP2025509730A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17/695,645 US12485178B2 (en) 2018-04-09 2022-03-15 Bifunctional small molecules to target the selective degradation of circulating proteins
US17/695,645 2022-03-15
PCT/US2023/064470 WO2023178202A2 (en) 2022-03-15 2023-03-15 Bifunctional small molecules to target the selective degradation of circulating proteins

Publications (2)

Publication Number Publication Date
JP2025509730A JP2025509730A (ja) 2025-04-11
JP2025509730A5 true JP2025509730A5 (https=) 2026-03-24

Family

ID=88024440

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024555107A Pending JP2025509730A (ja) 2022-03-15 2023-03-15 循環タンパク質の選択的分解を目的とした二官能性小分子

Country Status (8)

Country Link
EP (1) EP4493222A2 (https=)
JP (1) JP2025509730A (https=)
KR (1) KR20240166514A (https=)
CN (1) CN119255822A (https=)
AU (1) AU2023236291A1 (https=)
IL (1) IL315579A (https=)
MX (1) MX2024011338A (https=)
WO (1) WO2023178202A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4370157A1 (en) 2021-07-14 2024-05-22 Lycia Therapeutics, Inc. Asgpr cell surface receptor binding compounds and conjugates
WO2025219911A1 (en) * 2024-04-16 2025-10-23 Biohaven Therapeutics Ltd. Treatment of diseases with monoclonal antibody drugs and molecular degraders
WO2025248469A1 (en) * 2024-05-28 2025-12-04 Biohaven Therapeutics Ltd. TREATMENT OF IgG-RELATED DISEASES

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3356415B1 (en) * 2015-09-29 2024-05-01 Amgen Inc. Asgr inhibitors for reduzing cholesterol levels
WO2019199621A1 (en) * 2018-04-09 2019-10-17 Yale University Bi-functional molecules to degrade circulating proteins
EP3773727A4 (en) * 2018-04-09 2022-05-04 Yale University BIFUNCTIONAL SMALL MOLECULES TO TARGETING THE SELECTIVE DEGRADATION OF CIRCULATING PROTEINS
AU2019404061A1 (en) * 2018-12-19 2021-07-22 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules for lysosomal targeting and related compositions and methods
WO2021155317A1 (en) * 2020-01-31 2021-08-05 Avilar Therapeutics, Inc. Asgpr-binding compounds for the degradation of extracellular proteins

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