JPWO2023100975A5 - - Google Patents
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- Publication number
- JPWO2023100975A5 JPWO2023100975A5 JP2023504043A JP2023504043A JPWO2023100975A5 JP WO2023100975 A5 JPWO2023100975 A5 JP WO2023100975A5 JP 2023504043 A JP2023504043 A JP 2023504043A JP 2023504043 A JP2023504043 A JP 2023504043A JP WO2023100975 A5 JPWO2023100975 A5 JP WO2023100975A5
- Authority
- JP
- Japan
- Prior art keywords
- minutes
- mobile phase
- seq
- chain
- poloxamer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001983 poloxamer Polymers 0.000 claims 38
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 32
- 229960000502 poloxamer Drugs 0.000 claims 32
- 239000007864 aqueous solution Substances 0.000 claims 19
- 238000000034 method Methods 0.000 claims 15
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 14
- 239000004094 surface-active agent Substances 0.000 claims 13
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 12
- 238000004128 high performance liquid chromatography Methods 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 229910021642 ultra pure water Inorganic materials 0.000 claims 8
- 239000012498 ultrapure water Substances 0.000 claims 8
- 238000010828 elution Methods 0.000 claims 7
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 7
- 239000002245 particle Substances 0.000 claims 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims 7
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims 7
- CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical compound C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- 238000000105 evaporative light scattering detection Methods 0.000 claims 4
- 238000010438 heat treatment Methods 0.000 claims 4
- 239000006199 nebulizer Substances 0.000 claims 4
- 229920001214 Polysorbate 60 Polymers 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229920000136 polysorbate Polymers 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 229940068968 polysorbate 80 Drugs 0.000 claims 2
- 229940068965 polysorbates Drugs 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023176016A JP7550286B2 (ja) | 2021-12-01 | 2023-10-11 | 抗体含有製剤の調製方法 |
| JP2024150452A JP2024170482A (ja) | 2021-12-01 | 2024-09-02 | 抗体含有製剤の調製方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021195788 | 2021-12-01 | ||
| JP2021195788 | 2021-12-01 | ||
| PCT/JP2022/044355 WO2023100975A1 (ja) | 2021-12-01 | 2022-12-01 | 抗体含有製剤の調製方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023176016A Division JP7550286B2 (ja) | 2021-12-01 | 2023-10-11 | 抗体含有製剤の調製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2023100975A1 JPWO2023100975A1 (https=) | 2023-06-08 |
| JP7367262B1 JP7367262B1 (ja) | 2023-10-23 |
| JPWO2023100975A5 true JPWO2023100975A5 (https=) | 2023-11-02 |
Family
ID=86612242
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023504043A Active JP7367262B1 (ja) | 2021-12-01 | 2022-12-01 | 抗体含有製剤の調製方法 |
| JP2023176016A Active JP7550286B2 (ja) | 2021-12-01 | 2023-10-11 | 抗体含有製剤の調製方法 |
| JP2024150452A Pending JP2024170482A (ja) | 2021-12-01 | 2024-09-02 | 抗体含有製剤の調製方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023176016A Active JP7550286B2 (ja) | 2021-12-01 | 2023-10-11 | 抗体含有製剤の調製方法 |
| JP2024150452A Pending JP2024170482A (ja) | 2021-12-01 | 2024-09-02 | 抗体含有製剤の調製方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12460015B2 (https=) |
| EP (1) | EP4442274A4 (https=) |
| JP (3) | JP7367262B1 (https=) |
| KR (1) | KR20240011866A (https=) |
| CN (1) | CN118414166A (https=) |
| AU (1) | AU2022399314A1 (https=) |
| CA (1) | CA3239389A1 (https=) |
| IL (1) | IL313202A (https=) |
| MX (1) | MX2024006387A (https=) |
| TW (1) | TW202333787A (https=) |
| WO (1) | WO2023100975A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2024380406A1 (en) * | 2023-11-15 | 2026-04-16 | Biotest Ag | Method of manufacturing an igm containing composition |
Family Cites Families (57)
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| JPS58201994A (ja) | 1982-05-21 | 1983-11-25 | Hideaki Hagiwara | 抗原特異的ヒト免疫グロブリンの生産方法 |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
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| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| EP0585287B1 (en) | 1990-07-10 | 1999-10-13 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
| US5696298A (en) | 1991-03-19 | 1997-12-09 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| AU665025B2 (en) | 1991-09-23 | 1995-12-14 | Cambridge Antibody Technology Limited | Production of chimeric antibodies - a combinatorial approach |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| ES2341666T3 (es) | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| CA2124967C (en) | 1991-12-17 | 2008-04-08 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| DE69333823T2 (de) | 1992-03-24 | 2006-05-04 | Cambridge Antibody Technology Ltd., Melbourn | Verfahren zur herstellung von gliedern von spezifischen bindungspaaren |
| NZ255101A (en) | 1992-07-24 | 1997-08-22 | Cell Genesys Inc | A yeast artificial chromosome (yac) vector containing an hprt minigene expressible in murine stem cells and genetically modified rodent therefor |
| CA2161351C (en) | 1993-04-26 | 2010-12-21 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
| EP0731842A1 (en) | 1993-12-03 | 1996-09-18 | Medical Research Council | Recombinant binding proteins and peptides |
| CA2194907A1 (en) | 1994-07-13 | 1996-02-01 | Kouji Matsushima | Reshaped human antibody against human interleukin-8 |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| US6610833B1 (en) | 1997-11-24 | 2003-08-26 | The Institute For Human Genetics And Biochemistry | Monoclonal human natural antibodies |
| ES2375931T3 (es) | 1997-12-05 | 2012-03-07 | The Scripps Research Institute | Humanización de anticuerpo murino. |
| AU784983B2 (en) | 1999-12-15 | 2006-08-17 | Genentech Inc. | Shotgun scanning, a combinatorial method for mapping functional protein epitopes |
| CN101289511A (zh) | 2000-04-11 | 2008-10-22 | 杰南技术公司 | 多价抗体及其应用 |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| CN1487996B (zh) | 2000-11-30 | 2010-06-16 | 米德列斯公司 | 用于生产人类抗体的转基因转染色体啮齿动物 |
| EP1513879B1 (en) | 2002-06-03 | 2018-08-22 | Genentech, Inc. | Synthetic antibody phage libraries |
| CA2510003A1 (en) | 2003-01-16 | 2004-08-05 | Genentech, Inc. | Synthetic antibody phage libraries |
| KR101235507B1 (ko) * | 2003-02-28 | 2013-02-20 | 추가이 세이야쿠 가부시키가이샤 | 단백질을 함유하는 안정화 제제 |
| CN1961003B (zh) | 2004-03-31 | 2013-03-27 | 健泰科生物技术公司 | 人源化抗TGF-β抗体 |
| US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
| ATE547161T1 (de) | 2005-09-14 | 2012-03-15 | Ares Trading Sa | Verfahren zur quantitativen bestimmung von poloxameren |
| EP1951395B1 (en) | 2005-09-14 | 2012-02-29 | Ares Trading S.A. | Method for the quantitative determination of poloxamers |
| EP1957531B1 (en) | 2005-11-07 | 2016-04-13 | Genentech, Inc. | Binding polypeptides with diversified and consensus vh/vl hypervariable sequences |
| WO2007064919A2 (en) | 2005-12-02 | 2007-06-07 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| JP2009536527A (ja) | 2006-05-09 | 2009-10-15 | ジェネンテック・インコーポレーテッド | 最適化されたスキャフォールドを備えた結合ポリペプチド |
| WO2008027236A2 (en) | 2006-08-30 | 2008-03-06 | Genentech, Inc. | Multispecific antibodies |
| CN100592373C (zh) | 2007-05-25 | 2010-02-24 | 群康科技(深圳)有限公司 | 液晶显示面板驱动装置及其驱动方法 |
| AU2008304748C1 (en) | 2007-09-26 | 2014-06-12 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant region |
| ES2563027T3 (es) | 2008-01-07 | 2016-03-10 | Amgen Inc. | Método para fabricación de moléculas heterodímeras Fc de anticuerpos utilizando efectos de conducción electrostática |
| PH12016502073B1 (en) * | 2010-11-17 | 2024-04-05 | Chugai Pharmaceutical Co Ltd | Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii |
| KR101343040B1 (ko) | 2010-12-28 | 2013-12-18 | 주식회사 삼양바이오팜 | 정제된 폴록사머 및 그의 정제방법 |
| PL3160552T3 (pl) | 2014-06-30 | 2020-03-31 | Syqe Medical Ltd. | Wkład z dawką leku dla urządzenia inhalacyjnego |
| KR102482733B1 (ko) | 2014-06-30 | 2022-12-29 | 사이키 메디컬 엘티디. | 유동 조절 흡입기 디바이스 |
| JP6130983B2 (ja) | 2015-02-27 | 2017-05-17 | 中外製薬株式会社 | Ｉｌ−６関連疾患治療用組成物 |
| EP3430072B1 (en) | 2016-03-17 | 2020-07-01 | Merck Patent GmbH | Method for purifying poloxamers |
| MA44780A (fr) * | 2016-04-28 | 2019-03-06 | Chugai Pharmaceutical Co Ltd | Préparation contenant un anticorps |
| RU2766233C2 (ru) | 2016-09-06 | 2022-02-10 | Чугаи Сейяку Кабусики Кайся | Способы применения биспецифического антитела, которое распознает фактор свертывания ix и/или активированный фактор свертывания ix и фактор свертывания x и/или активированный фактор свертывания x |
| WO2019060062A1 (en) | 2017-09-19 | 2019-03-28 | Regeneron Pharmaceuticals Inc. | METHODS OF REDUCING PARTICLE FORMATION AND COMPOSITIONS FORMED THEREFROM |
| AU2021278562A1 (en) * | 2020-05-29 | 2022-12-01 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing formulation |
-
2022
- 2022-12-01 JP JP2023504043A patent/JP7367262B1/ja active Active
- 2022-12-01 CN CN202280079587.2A patent/CN118414166A/zh active Pending
- 2022-12-01 WO PCT/JP2022/044355 patent/WO2023100975A1/ja not_active Ceased
- 2022-12-01 KR KR1020247000885A patent/KR20240011866A/ko not_active Ceased
- 2022-12-01 IL IL313202A patent/IL313202A/en unknown
- 2022-12-01 CA CA3239389A patent/CA3239389A1/en active Pending
- 2022-12-01 US US18/715,020 patent/US12460015B2/en active Active
- 2022-12-01 MX MX2024006387A patent/MX2024006387A/es unknown
- 2022-12-01 AU AU2022399314A patent/AU2022399314A1/en active Pending
- 2022-12-01 TW TW111146149A patent/TW202333787A/zh unknown
- 2022-12-01 EP EP22901405.5A patent/EP4442274A4/en active Pending
-
2023
- 2023-10-11 JP JP2023176016A patent/JP7550286B2/ja active Active
-
2024
- 2024-09-02 JP JP2024150452A patent/JP2024170482A/ja active Pending
-
2025
- 2025-10-06 US US19/350,318 patent/US20260022194A1/en active Pending
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