JPWO2023054706A5 - - Google Patents
Info
- Publication number
- JPWO2023054706A5 JPWO2023054706A5 JP2023551923A JP2023551923A JPWO2023054706A5 JP WO2023054706 A5 JPWO2023054706 A5 JP WO2023054706A5 JP 2023551923 A JP2023551923 A JP 2023551923A JP 2023551923 A JP2023551923 A JP 2023551923A JP WO2023054706 A5 JPWO2023054706 A5 JP WO2023054706A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- residue
- hydrophilic
- salt
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021162299 | 2021-09-30 | ||
| JP2021207541 | 2021-12-21 | ||
| PCT/JP2022/036835 WO2023054706A1 (ja) | 2021-09-30 | 2022-09-30 | 抗体および機能性物質のコンジュゲートまたはその塩、ならびにその製造に用いられる抗体誘導体および化合物またはそれらの塩 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2023054706A1 JPWO2023054706A1 (https=) | 2023-04-06 |
| JPWO2023054706A5 true JPWO2023054706A5 (https=) | 2026-02-24 |
Family
ID=85780804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023551923A Pending JPWO2023054706A1 (https=) | 2021-09-30 | 2022-09-30 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240285788A1 (https=) |
| EP (1) | EP4410830A1 (https=) |
| JP (1) | JPWO2023054706A1 (https=) |
| KR (1) | KR20240073035A (https=) |
| AU (1) | AU2022357933A1 (https=) |
| CA (1) | CA3234692A1 (https=) |
| WO (1) | WO2023054706A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250167673A (ko) * | 2023-04-05 | 2025-12-01 | 아지노모토 가부시키가이샤 | 항체 및 기능성 물질의 컨쥬게이트 또는 그 염, 및 티올기를 갖는 항체 중간체 또는 그 염 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL106992A (en) | 1988-02-11 | 1994-06-24 | Bristol Myers Squibb Co | Acylhydrazone derivatives of anthracycline and methods for their preparation |
| US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| ATE234635T1 (de) | 1995-12-22 | 2003-04-15 | Bristol Myers Squibb Co | Verzweigte hydrazongruppen enthaltende kuppler |
| EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| SI1545613T1 (sl) | 2002-07-31 | 2011-11-30 | Seattle Genetics Inc | Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni |
| JP2006507322A (ja) | 2002-11-14 | 2006-03-02 | シンタルガ・ビーブイ | 多重自己脱離放出スペーサーとして構築されたプロドラッグ |
| US7498298B2 (en) | 2003-11-06 | 2009-03-03 | Seattle Genetics, Inc. | Monomethylvaline compounds capable of conjugation to ligands |
| JP4806680B2 (ja) | 2004-05-19 | 2011-11-02 | メダレックス インコーポレイテッド | 自己犠牲リンカー及び薬剤複合体 |
| KR101497137B1 (ko) | 2011-12-30 | 2015-03-03 | 제일모직 주식회사 | 유기광전자소자용 화합물, 이를 포함하는 유기발광소자 및 상기 유기발광소자를 포함하는 표시장치 |
| EP2690183B1 (de) | 2012-07-27 | 2017-06-28 | ThyssenKrupp Steel Europe AG | Warmgewalztes Stahlflachprodukt und Verfahren zu seiner Herstellung |
| DK2907824T3 (en) | 2012-10-11 | 2018-07-23 | Daiichi Sankyo Co Ltd | ANTIBODY-drug conjugate |
| RU2015129800A (ru) * | 2012-12-21 | 2017-01-30 | Биоэллаенс К. В. | Гидрофильные саморазрушающиеся линкеры и их конъюгаты |
| DE102013104806A1 (de) | 2013-05-08 | 2014-11-13 | Sandvik Materials Technology Deutschland Gmbh | Bandofen |
| WO2015038426A1 (en) | 2013-09-13 | 2015-03-19 | Asana Biosciences, Llc | Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof |
| TW201632531A (zh) * | 2015-01-14 | 2016-09-16 | 必治妥美雅史谷比公司 | 苯二氮呯二聚物，其結合物及製造與使用方法 |
| CN107406496A (zh) * | 2015-03-10 | 2017-11-28 | 百时美施贵宝公司 | 可通过转谷氨酰胺酶缀合的抗体和由其制备的缀合物 |
| CN109641911B (zh) * | 2016-08-19 | 2023-02-21 | 百时美施贵宝公司 | seco-环丙吡咯并吲哚化合物和其抗体-药物缀合物以及制备和使用方法 |
| EP3617235B1 (en) | 2017-04-28 | 2026-02-18 | Ajinomoto Co., Inc. | Compound having substance that has affinity for soluble protein, cleavable moiety, and reactive group, or salt thereof |
| CN118652192A (zh) | 2017-05-24 | 2024-09-17 | 德克萨斯州大学系统董事会 | 用于抗体药物缀合物的接头 |
| CA3063325A1 (en) * | 2017-06-21 | 2018-12-27 | Glykos Finland Oy | Hydrophilic linkers and conjugates thereof |
| WO2019057772A1 (en) * | 2017-09-19 | 2019-03-28 | Paul Scherrer Institut | METHOD FOR CONJUGATING TRANSGLUTAMINASE AND BINDING SEQUENCE |
| CA3103143A1 (en) | 2018-06-14 | 2019-12-19 | Ajinomoto Co., Inc. | Compound having affinity substance to antibody, cleavable portion, and reactive group, or salt thereof |
| CN112261954B (zh) | 2018-06-14 | 2025-06-24 | 味之素株式会社 | 具有针对抗体的亲和性物质和生物正交性官能团的化合物或其盐 |
| JPWO2020090979A1 (ja) | 2018-10-31 | 2021-09-24 | 味の素株式会社 | 抗体に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩 |
| EP3970752A1 (en) * | 2020-09-17 | 2022-03-23 | Merck Patent GmbH | Molecules with solubility tag and related methods |
-
2022
- 2022-09-30 KR KR1020247010605A patent/KR20240073035A/ko active Pending
- 2022-09-30 JP JP2023551923A patent/JPWO2023054706A1/ja active Pending
- 2022-09-30 CA CA3234692A patent/CA3234692A1/en active Pending
- 2022-09-30 WO PCT/JP2022/036835 patent/WO2023054706A1/ja not_active Ceased
- 2022-09-30 AU AU2022357933A patent/AU2022357933A1/en active Pending
- 2022-09-30 EP EP22876568.1A patent/EP4410830A1/en active Pending
-
2024
- 2024-03-28 US US18/619,910 patent/US20240285788A1/en active Pending
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