JPWO2023048291A5 - - Google Patents
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- Publication number
- JPWO2023048291A5 JPWO2023048291A5 JP2023549778A JP2023549778A JPWO2023048291A5 JP WO2023048291 A5 JPWO2023048291 A5 JP WO2023048291A5 JP 2023549778 A JP2023549778 A JP 2023549778A JP 2023549778 A JP2023549778 A JP 2023549778A JP WO2023048291 A5 JPWO2023048291 A5 JP WO2023048291A5
- Authority
- JP
- Japan
- Prior art keywords
- trna
- nucleic acid
- polypeptide
- codon
- unnatural amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020004566 Transfer RNA Proteins 0.000 claims 44
- 229920001184 polypeptide Polymers 0.000 claims 27
- 108020005038 Terminator Codon Proteins 0.000 claims 23
- 108020004707 nucleic acids Proteins 0.000 claims 16
- 102000039446 nucleic acids Human genes 0.000 claims 16
- 150000007523 nucleic acids Chemical class 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims 14
- 150000001413 amino acids Chemical class 0.000 claims 13
- 108020005098 Anticodon Proteins 0.000 claims 11
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 241000202934 Mycoplasma pneumoniae Species 0.000 claims 6
- 241000204025 Mycoplasma capricolum Species 0.000 claims 5
- 241000023308 Acca Species 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000010647 peptide synthesis reaction Methods 0.000 claims 3
- 108020004705 Codon Proteins 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- SCIFESDRCALIIM-UHFFFAOYSA-N N-Me-Phenylalanine Natural products CNC(C(O)=O)CC1=CC=CC=C1 SCIFESDRCALIIM-UHFFFAOYSA-N 0.000 claims 1
- GDFAOVXKHJXLEI-VKHMYHEASA-N N-methyl-L-alanine Chemical compound C[NH2+][C@@H](C)C([O-])=O GDFAOVXKHJXLEI-VKHMYHEASA-N 0.000 claims 1
- SCIFESDRCALIIM-VIFPVBQESA-N N-methyl-L-phenylalanine Chemical compound C[NH2+][C@H](C([O-])=O)CC1=CC=CC=C1 SCIFESDRCALIIM-VIFPVBQESA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 229950010131 puromycin Drugs 0.000 claims 1
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Natural products C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021156183 | 2021-09-24 | ||
| PCT/JP2022/035791 WO2023048291A1 (ja) | 2021-09-24 | 2022-09-26 | ｔＲＮＡ、アミノアシルｔＲＮＡ、ポリペプチド合成用試薬、非天然アミノ酸の導入方法、ポリペプチドの作製方法、核酸ディスプレイライブラリの作製方法、核酸－ポリペプチド連結体及びスクリーニング方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2023048291A1 JPWO2023048291A1 (https=) | 2023-03-30 |
| JPWO2023048291A5 true JPWO2023048291A5 (https=) | 2024-06-13 |
Family
ID=85720849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023549778A Pending JPWO2023048291A1 (https=) | 2021-09-24 | 2022-09-26 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240229015A1 (https=) |
| EP (1) | EP4389890A4 (https=) |
| JP (1) | JPWO2023048291A1 (https=) |
| CN (1) | CN118019845A (https=) |
| WO (1) | WO2023048291A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024214800A1 (ja) * | 2023-04-11 | 2024-10-17 | 富士フイルム株式会社 | 生理活性評価用のポリペプチド溶液を調製する方法、及びポリペプチドの生理活性を評価する方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003281613A1 (en) | 2002-07-18 | 2004-02-09 | Takahiro Hohsaka | NON-NATURAL LABELED AMINO ACID AND METHOD OF CONSTRUCTING AMINO ACID/tRNA COMPLEX |
| WO2007055429A1 (ja) | 2005-11-14 | 2007-05-18 | Japan Science And Technology Agency | 非天然アミノ酸をタンパク質に導入するためのtRNA変異体 |
| JP2008193911A (ja) * | 2007-02-08 | 2008-08-28 | Protein Express:Kk | タンパク質のｎ末端を特異的に修飾する方法 |
| JP5818237B2 (ja) * | 2010-09-09 | 2015-11-18 | 国立大学法人 東京大学 | Ｎ−メチルアミノ酸およびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法 |
| RU2731211C1 (ru) | 2017-03-21 | 2020-08-31 | Фуджифилм Корпорэйшн | Пептидное соединение и способ его получения, композиция для скринингового использования и способ отбора пептидного соединения |
| KR102930465B1 (ko) * | 2017-11-02 | 2026-02-25 | 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 | ACE-tRNA를 이용한 유전 재할당을 통한 정지 코돈의 구조 방법 |
| US20220325269A1 (en) * | 2019-08-08 | 2022-10-13 | Brickbio, Inc. | Aminoacyl-trna synthetases and cell lines for site-specific incorporation of unnatural amino acids |
| JP7211389B2 (ja) | 2020-03-25 | 2023-01-24 | トヨタ自動車株式会社 | 内燃機関の制御装置 |
-
2022
- 2022-09-26 WO PCT/JP2022/035791 patent/WO2023048291A1/ja not_active Ceased
- 2022-09-26 JP JP2023549778A patent/JPWO2023048291A1/ja active Pending
- 2022-09-26 EP EP22873042.0A patent/EP4389890A4/en active Pending
- 2022-09-26 CN CN202280063245.1A patent/CN118019845A/zh active Pending
-
2024
- 2024-03-21 US US18/611,981 patent/US20240229015A1/en active Pending
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