JPWO2022051449A5 - - Google Patents
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- Publication number
- JPWO2022051449A5 JPWO2022051449A5 JP2023515071A JP2023515071A JPWO2022051449A5 JP WO2022051449 A5 JPWO2022051449 A5 JP WO2022051449A5 JP 2023515071 A JP2023515071 A JP 2023515071A JP 2023515071 A JP2023515071 A JP 2023515071A JP WO2022051449 A5 JPWO2022051449 A5 JP WO2022051449A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- polypeptide chain
- chain comprises
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 899
- 108090000765 processed proteins & peptides Proteins 0.000 claims 277
- 229920001184 polypeptide Polymers 0.000 claims 274
- 102000004196 processed proteins & peptides Human genes 0.000 claims 274
- 210000004027 cell Anatomy 0.000 claims 23
- 108091008874 T cell receptors Proteins 0.000 claims 22
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 22
- 102000004169 proteins and genes Human genes 0.000 claims 20
- 108090000623 proteins and genes Proteins 0.000 claims 20
- 150000007523 nucleic acids Chemical class 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 101100462513 Homo sapiens TP53 gene Proteins 0.000 claims 7
- 239000013604 expression vector Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 238000003259 recombinant expression Methods 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 210000000581 natural killer T-cell Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063074747P | 2020-09-04 | 2020-09-04 | |
| US63/074,747 | 2020-09-04 | ||
| PCT/US2021/048786 WO2022051449A2 (en) | 2020-09-04 | 2021-09-02 | T cell receptors recognizing r273c or y220c mutations in p53 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023540123A JP2023540123A (ja) | 2023-09-21 |
| JPWO2022051449A5 true JPWO2022051449A5 (https=) | 2024-09-06 |
| JP2023540123A5 JP2023540123A5 (https=) | 2024-09-06 |
Family
ID=77924530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023515071A Pending JP2023540123A (ja) | 2020-09-04 | 2021-09-02 | Ｐ５３におけるｒ２７３ｃ又はｙ２２０ｃの変異を認識するｔ細胞受容体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230321240A1 (https=) |
| EP (1) | EP4208473A2 (https=) |
| JP (1) | JP2023540123A (https=) |
| KR (1) | KR20230066023A (https=) |
| CN (1) | CN116472050A (https=) |
| AU (1) | AU2021336399A1 (https=) |
| CA (1) | CA3191186A1 (https=) |
| GB (1) | GB2614166A (https=) |
| TW (1) | TWI900647B (https=) |
| WO (1) | WO2022051449A2 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024206274A2 (en) | 2023-03-27 | 2024-10-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors targeting y220c or r175h mutation in p53 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003265948B8 (en) | 2002-09-06 | 2009-09-03 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| WO2012129201A1 (en) | 2011-03-22 | 2012-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| IL290655B2 (en) | 2014-05-29 | 2024-05-01 | Us Health | Anti-human papillomavirus 16 E7 T-cell chelates |
| WO2018102585A1 (en) * | 2016-11-30 | 2018-06-07 | Advaxis, Inc. | Personalized immunotherapy in combination with immunotherapy targeting recurrent cancer mutations |
| AU2018318303A1 (en) * | 2017-08-18 | 2020-04-09 | Gritstone Bio, Inc. | Antigen-binding proteins targeting shared antigens |
| CA3080274A1 (en) * | 2017-09-29 | 2019-04-04 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods of isolating t cells having antigenic specificity for a p53 cancer-specific mutation |
| EA202090757A1 (ru) * | 2017-09-29 | 2020-08-21 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | T-КЛЕТОЧНЫЕ РЕЦЕПТОРЫ, РАСПОЗНАЮЩИЕ МУТАНТНЫЙ p53 |
-
2021
- 2021-09-02 EP EP21778318.2A patent/EP4208473A2/en active Pending
- 2021-09-02 AU AU2021336399A patent/AU2021336399A1/en active Pending
- 2021-09-02 GB GB2304187.4A patent/GB2614166A/en active Pending
- 2021-09-02 JP JP2023515071A patent/JP2023540123A/ja active Pending
- 2021-09-02 CN CN202180071809.1A patent/CN116472050A/zh active Pending
- 2021-09-02 KR KR1020237011380A patent/KR20230066023A/ko active Pending
- 2021-09-02 WO PCT/US2021/048786 patent/WO2022051449A2/en not_active Ceased
- 2021-09-02 TW TW110132552A patent/TWI900647B/zh active
- 2021-09-02 US US18/024,557 patent/US20230321240A1/en active Pending
- 2021-09-02 CA CA3191186A patent/CA3191186A1/en active Pending
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