JPWO2022015694A5 - - Google Patents
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- JPWO2022015694A5 JPWO2022015694A5 JP2023502572A JP2023502572A JPWO2022015694A5 JP WO2022015694 A5 JPWO2022015694 A5 JP WO2022015694A5 JP 2023502572 A JP2023502572 A JP 2023502572A JP 2023502572 A JP2023502572 A JP 2023502572A JP WO2022015694 A5 JPWO2022015694 A5 JP WO2022015694A5
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- amino acid
- acid sequence
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- Prior art date
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- 150000001413 amino acids Chemical group 0.000 claims 123
- 108090000765 processed proteins & peptides Proteins 0.000 claims 74
- 229920001184 polypeptide Polymers 0.000 claims 71
- 102000004196 processed proteins & peptides Human genes 0.000 claims 71
- 108091008874 T cell receptors Proteins 0.000 claims 23
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 22
- 210000004027 cell Anatomy 0.000 claims 22
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 235000018102 proteins Nutrition 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 102000016914 ras Proteins Human genes 0.000 claims 10
- 101000584633 Homo sapiens GTPase HRas Proteins 0.000 claims 8
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 claims 8
- 108010067802 HLA-DR alpha-Chains Proteins 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 239000013604 expression vector Substances 0.000 claims 7
- 239000000833 heterodimer Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 238000003259 recombinant expression Methods 0.000 claims 7
- 102100029974 GTPase HRas Human genes 0.000 claims 6
- 102100030708 GTPase KRas Human genes 0.000 claims 6
- 102100040505 HLA class II histocompatibility antigen, DR alpha chain Human genes 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 206010029260 Neuroblastoma Diseases 0.000 claims 3
- 108700020796 Oncogene Proteins 0.000 claims 3
- 206010039491 Sarcoma Diseases 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 2
- 102100040482 HLA class II histocompatibility antigen, DR beta 3 chain Human genes 0.000 claims 2
- 102100028636 HLA class II histocompatibility antigen, DR beta 4 chain Human genes 0.000 claims 2
- 108010061311 HLA-DRB3 Chains Proteins 0.000 claims 2
- 108010040960 HLA-DRB4 Chains Proteins 0.000 claims 2
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 235000003704 aspartic acid Nutrition 0.000 claims 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- 102000043600 human HRAS Human genes 0.000 claims 2
- 102000049555 human KRAS Human genes 0.000 claims 2
- 102000047526 human NRAS Human genes 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 102100040485 HLA class II histocompatibility antigen, DRB1 beta chain Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010053491 HLA-DR beta-Chains Proteins 0.000 claims 1
- 108010039343 HLA-DRB1 Chains Proteins 0.000 claims 1
- 101150018610 HLA-DRB1 gene Proteins 0.000 claims 1
- 102210026620 HLA-DRB1*03 Human genes 0.000 claims 1
- 101150022563 HLA-DRB3 gene Proteins 0.000 claims 1
- 101150084888 HLA-DRB4 gene Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000002357 endometrial effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000581 natural killer T-cell Anatomy 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000009258 tissue cross reactivity Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063050931P | 2020-07-13 | 2020-07-13 | |
| US63/050,931 | 2020-07-13 | ||
| PCT/US2021/041375 WO2022015694A1 (en) | 2020-07-13 | 2021-07-13 | Hla class ii–restricted drb t cell receptors against ras with g12d mutation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023534241A JP2023534241A (ja) | 2023-08-08 |
| JP2023534241A5 JP2023534241A5 (https=) | 2024-07-18 |
| JPWO2022015694A5 true JPWO2022015694A5 (https=) | 2024-07-18 |
Family
ID=77227130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023502572A Pending JP2023534241A (ja) | 2020-07-13 | 2021-07-13 | Ｇ１２ｄ変異を有するｒａｓに対するｈｌａクラスｉｉ拘束性ｄｒｂ ｔ細胞受容体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230272038A1 (https=) |
| EP (1) | EP4178976A1 (https=) |
| JP (1) | JP2023534241A (https=) |
| KR (1) | KR20230043881A (https=) |
| CN (1) | CN116322734A (https=) |
| AU (1) | AU2021310213A1 (https=) |
| CA (1) | CA3185241A1 (https=) |
| WO (1) | WO2022015694A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2022227029A1 (en) | 2021-02-26 | 2023-08-31 | New York University | Compositions and methods comprising antibodies that bind to covalent peptide conjugates |
| CN118852403A (zh) * | 2023-04-26 | 2024-10-29 | 北京鼎成肽源生物技术有限公司 | 靶向kras突变的tcr分子和细胞及其应用 |
| CN120157754A (zh) * | 2023-12-14 | 2025-06-17 | 新景智源生物科技(苏州)有限公司 | Kras_g12d突变抗原特异性tcr及其与cd8共表达重定向cd4 t细胞 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL150732A0 (en) * | 2000-01-14 | 2003-02-12 | Corixa Corp | Prostate specific polypeptides, polynucleotides that encode said polypeptides and pharmaceutical compositions containing the same |
| AU2003265948B8 (en) | 2002-09-06 | 2009-09-03 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| WO2012129201A1 (en) | 2011-03-22 | 2012-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| WO2018026691A1 (en) * | 2016-08-02 | 2018-02-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-kras-g12d t cell receptors |
| CN108395479B (zh) * | 2017-02-06 | 2021-07-16 | 高军 | 一种有关kras基因突变的t细胞受体 |
| EP3684799A1 (en) * | 2017-09-20 | 2020-07-29 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Hla class ii restricted t cell receptors against mutated ras |
-
2021
- 2021-07-13 WO PCT/US2021/041375 patent/WO2022015694A1/en not_active Ceased
- 2021-07-13 AU AU2021310213A patent/AU2021310213A1/en active Pending
- 2021-07-13 KR KR1020237004523A patent/KR20230043881A/ko active Pending
- 2021-07-13 CA CA3185241A patent/CA3185241A1/en active Pending
- 2021-07-13 JP JP2023502572A patent/JP2023534241A/ja active Pending
- 2021-07-13 US US18/015,776 patent/US20230272038A1/en active Pending
- 2021-07-13 CN CN202180061706.7A patent/CN116322734A/zh active Pending
- 2021-07-13 EP EP21751702.8A patent/EP4178976A1/en active Pending
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