KR20230043881A - G12d 돌연변이를 갖는 ras에 대한 hla 클래스 ii-제한된 drb t 세포 수용체 - Google Patents

G12d 돌연변이를 갖는 ras에 대한 hla 클래스 ii-제한된 drb t 세포 수용체 Download PDF

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KR20230043881A
KR20230043881A KR1020237004523A KR20237004523A KR20230043881A KR 20230043881 A KR20230043881 A KR 20230043881A KR 1020237004523 A KR1020237004523 A KR 1020237004523A KR 20237004523 A KR20237004523 A KR 20237004523A KR 20230043881 A KR20230043881 A KR 20230043881A
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노암 레빈
라미 요셉
갈 카프리
스티븐 에이 로젠버그
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더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4244—Enzymes
    • A61K40/4253—GTPases, e.g. Ras or Rho
    • A—HUMAN NECESSITIES
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KR1020237004523A 2020-07-13 2021-07-13 G12d 돌연변이를 갖는 ras에 대한 hla 클래스 ii-제한된 drb t 세포 수용체 Pending KR20230043881A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063050931P 2020-07-13 2020-07-13
US63/050,931 2020-07-13
PCT/US2021/041375 WO2022015694A1 (en) 2020-07-13 2021-07-13 Hla class ii–restricted drb t cell receptors against ras with g12d mutation

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KR20230043881A true KR20230043881A (ko) 2023-03-31

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KR1020237004523A Pending KR20230043881A (ko) 2020-07-13 2021-07-13 G12d 돌연변이를 갖는 ras에 대한 hla 클래스 ii-제한된 drb t 세포 수용체

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US (1) US20230272038A1 (https=)
EP (1) EP4178976A1 (https=)
JP (1) JP2023534241A (https=)
KR (1) KR20230043881A (https=)
CN (1) CN116322734A (https=)
AU (1) AU2021310213A1 (https=)
CA (1) CA3185241A1 (https=)
WO (1) WO2022015694A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022227029A1 (en) 2021-02-26 2023-08-31 New York University Compositions and methods comprising antibodies that bind to covalent peptide conjugates
CN118852403A (zh) * 2023-04-26 2024-10-29 北京鼎成肽源生物技术有限公司 靶向kras突变的tcr分子和细胞及其应用
CN120157754A (zh) * 2023-12-14 2025-06-17 新景智源生物科技(苏州)有限公司 Kras_g12d突变抗原特异性tcr及其与cd8共表达重定向cd4 t细胞

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL150732A0 (en) * 2000-01-14 2003-02-12 Corixa Corp Prostate specific polypeptides, polynucleotides that encode said polypeptides and pharmaceutical compositions containing the same
AU2003265948B8 (en) 2002-09-06 2009-09-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
WO2012129201A1 (en) 2011-03-22 2012-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
WO2018026691A1 (en) * 2016-08-02 2018-02-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-kras-g12d t cell receptors
CN108395479B (zh) * 2017-02-06 2021-07-16 高军 一种有关kras基因突变的t细胞受体
EP3684799A1 (en) * 2017-09-20 2020-07-29 The U.S.A. as represented by the Secretary, Department of Health and Human Services Hla class ii restricted t cell receptors against mutated ras

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Publication number Publication date
WO2022015694A8 (en) 2023-01-12
US20230272038A1 (en) 2023-08-31
AU2021310213A1 (en) 2023-03-09
JP2023534241A (ja) 2023-08-08
CA3185241A1 (en) 2022-01-20
CN116322734A (zh) 2023-06-23
WO2022015694A1 (en) 2022-01-20
EP4178976A1 (en) 2023-05-17

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