JP2021505136A5 - - Google Patents
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- JP2021505136A5 JP2021505136A5 JP2020530325A JP2020530325A JP2021505136A5 JP 2021505136 A5 JP2021505136 A5 JP 2021505136A5 JP 2020530325 A JP2020530325 A JP 2020530325A JP 2020530325 A JP2020530325 A JP 2020530325A JP 2021505136 A5 JP2021505136 A5 JP 2021505136A5
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023133670A JP7620676B2 (ja) | 2017-12-04 | 2023-08-18 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
| JP2025003895A JP2025072378A (ja) | 2017-12-04 | 2025-01-10 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762594244P | 2017-12-04 | 2017-12-04 | |
| US62/594,244 | 2017-12-04 | ||
| PCT/US2018/063581 WO2019112941A1 (en) | 2017-12-04 | 2018-12-03 | Hla class i-restricted t cell receptors against mutated ras |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023133670A Division JP7620676B2 (ja) | 2017-12-04 | 2023-08-18 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021505136A JP2021505136A (ja) | 2021-02-18 |
| JP2021505136A5 true JP2021505136A5 (https=) | 2022-01-11 |
| JP7385566B2 JP7385566B2 (ja) | 2023-11-22 |
Family
ID=64949411
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020530325A Active JP7385566B2 (ja) | 2017-12-04 | 2018-12-03 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
| JP2023133670A Active JP7620676B2 (ja) | 2017-12-04 | 2023-08-18 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
| JP2025003895A Pending JP2025072378A (ja) | 2017-12-04 | 2025-01-10 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023133670A Active JP7620676B2 (ja) | 2017-12-04 | 2023-08-18 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
| JP2025003895A Pending JP2025072378A (ja) | 2017-12-04 | 2025-01-10 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11466071B2 (https=) |
| EP (1) | EP3720478A1 (https=) |
| JP (3) | JP7385566B2 (https=) |
| KR (1) | KR20200115484A (https=) |
| CN (2) | CN119162251A (https=) |
| AU (2) | AU2018378200B2 (https=) |
| BR (1) | BR112020011111A2 (https=) |
| CA (1) | CA3084246A1 (https=) |
| CR (1) | CR20200287A (https=) |
| EA (1) | EA202091335A1 (https=) |
| IL (1) | IL275031A (https=) |
| MA (2) | MA51043A (https=) |
| MX (1) | MX2020005765A (https=) |
| SG (1) | SG11202005236QA (https=) |
| WO (1) | WO2019112941A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11807662B2 (en) | 2017-05-16 | 2023-11-07 | The Johns Hopkins University | MANAbodies and methods of using |
| KR20210119468A (ko) * | 2019-01-25 | 2021-10-05 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 돌연변이체 ras를 표적화하기 위한 조성물 및 방법 |
| WO2020172332A1 (en) * | 2019-02-20 | 2020-08-27 | Fred Hutchinson Cancer Research Center | Binding proteins specific for ras neoantigens and uses thereof |
| EP3760217A1 (en) * | 2019-07-01 | 2021-01-06 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Cd5 specific t cell receptor cell or gene therapy |
| CN112646024B (zh) * | 2019-10-10 | 2023-03-24 | 香雪生命科学技术（广东）有限公司 | 一种识别kras突变的t细胞受体及其编码序列 |
| CN112759641B (zh) * | 2019-11-01 | 2023-01-20 | 香雪生命科学技术（广东）有限公司 | 一种识别Kras G12V的高亲和力TCR |
| US20230080742A1 (en) * | 2020-02-12 | 2023-03-16 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Hla class i-restricted t cell receptors against ras with g12d mutation |
| AU2021220957A1 (en) * | 2020-02-14 | 2022-09-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HLA class I-restricted T cell receptors against ras with G12V mutation |
| TWI900533B (zh) * | 2020-02-26 | 2025-10-11 | 美國衛生與公眾服務部 | 針對含有ｇ１２ｖ突變之ｒａｓ之ｈｌａ第ｉｉ類限制性ｔ細胞受體 |
| CN116348484A (zh) * | 2020-07-16 | 2023-06-27 | 美国卫生和人力服务部 | 针对含有g12v突变的ras的hla-ii类限制性drb t细胞受体 |
| TW202540156A (zh) * | 2020-10-02 | 2025-10-16 | 美國衛生與公眾服務部 | 針對含有g13d突變之ras之hla第ii類限制性dq t細胞受體 |
| KR102488353B1 (ko) * | 2020-10-08 | 2023-01-12 | 부산대학교 산학협력단 | 돌연변이 kras를 표적하는 펩타이드 및 이의 용도 |
| US20240000834A1 (en) * | 2020-11-24 | 2024-01-04 | Shanghai GenBase Biotechnology Co., Ltd. | Ras mutant epitope peptide and t cell receptor recognizing ras mutant |
| IL305393A (en) | 2021-02-25 | 2023-10-01 | Alaunos Therapeutics Inc | Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof |
| EP4347639A4 (en) * | 2021-05-25 | 2025-08-06 | Memorial Sloan Kettering Cancer Center | T CELL RECEPTORS TARGETING RAS MUTATIONS AND THEIR USES |
| JP2025504883A (ja) | 2022-01-21 | 2025-02-19 | テ－クニフェ ゲーエムベーハー | 決定可能な親和性で特定のペプチドを結合する抗原認識コンストラクト、およびｋｒａｓに抗原特異性を有するｔ細胞レセプター、ならびに、対応する核酸配列、ベクター、宿主細胞、医薬組成物、およびキット |
| US20250145950A1 (en) | 2022-02-01 | 2025-05-08 | Alaunos Therapeutics, Inc. | Methods for Activation and Expansion of T Cells |
| CN117264043B (zh) * | 2022-06-14 | 2024-05-10 | 上海镔铁生物科技有限责任公司 | 靶向kras g12v突变多肽的t细胞受体及其用途 |
| CN115850444B (zh) * | 2022-09-15 | 2025-01-28 | 重庆医科大学 | Tcr或其抗原结合片段及其应用 |
| CN115960204B (zh) * | 2022-11-04 | 2023-08-25 | 新景智源生物科技(苏州)有限公司 | Kras_g12v突变抗原特异性tcr及其与cd8共表达重定向cd4 t细胞 |
| CN118852452A (zh) * | 2023-04-28 | 2024-10-29 | 北京鼎成肽源生物技术有限公司 | 靶向kras g12突变的tcr分子和细胞及其应用 |
| CN118909132A (zh) * | 2023-05-06 | 2024-11-08 | 北京鼎成肽源生物技术有限公司 | 靶向kras g12v突变的tcr分子和细胞及其应用 |
| WO2025056681A1 (en) * | 2023-09-15 | 2025-03-20 | Medigene Immunotherapies Gmbh | T-CELL RECEPTOR AGAINST mKRAS7-16 G12V AND G12C |
| WO2025056672A1 (en) * | 2023-09-15 | 2025-03-20 | Medigene Immunotherapies Gmbh | T-CELL RECEPTOR VARIANT AGAINST mKRAS7-16 G12V |
| EP4570263A1 (en) * | 2023-12-15 | 2025-06-18 | Genovie AB | Tcrs recognizing g12v mutated ras and uses thereof |
| WO2025125590A2 (en) * | 2023-12-15 | 2025-06-19 | Genovie Ab | Tcr recognizing g12v mutated ras and uses thereof |
| WO2026024602A2 (en) * | 2024-07-22 | 2026-01-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors against ras with g12d, g12v, g13d or q61r mutation |
| CN119350472B (zh) * | 2024-12-25 | 2025-04-04 | 北京可瑞生物科技有限公司 | 修饰的靶向kras g12v的t细胞受体或其片段以及用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003265948B8 (en) | 2002-09-06 | 2009-09-03 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| CN103124740B (zh) * | 2010-09-21 | 2015-09-02 | 美国卫生和人力服务部 | 抗-ssx-2t细胞受体和相关材料及使用方法 |
| WO2012129201A1 (en) | 2011-03-22 | 2012-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| MX384919B (es) * | 2014-11-26 | 2025-03-14 | Us Health | Receptores de células t de kras anti-mutado. |
| JP7185524B2 (ja) | 2015-09-15 | 2022-12-07 | アメリカ合衆国 | Ｈｌａ－ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体 |
| HUE053674T2 (hu) * | 2015-12-23 | 2021-07-28 | Medigene Immunotherapies Gmbh | Antigén-specifikus TCR receptorok új generációja |
| US11026969B2 (en) * | 2015-12-23 | 2021-06-08 | Fred Hutchinson Cancer Research Center | High affinity T cell receptors and uses thereof |
| US12221627B2 (en) * | 2017-12-04 | 2025-02-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of enriching cell populations for cancer-specific T cells using in vitro stimulation of memory T cells |
-
2018
- 2018-12-03 EP EP18830062.8A patent/EP3720478A1/en active Pending
- 2018-12-03 CN CN202411410030.XA patent/CN119162251A/zh active Pending
- 2018-12-03 JP JP2020530325A patent/JP7385566B2/ja active Active
- 2018-12-03 CN CN201880087270.7A patent/CN111836638B/zh active Active
- 2018-12-03 CR CR20200287A patent/CR20200287A/es unknown
- 2018-12-03 WO PCT/US2018/063581 patent/WO2019112941A1/en not_active Ceased
- 2018-12-03 EA EA202091335A patent/EA202091335A1/ru unknown
- 2018-12-03 US US16/769,144 patent/US11466071B2/en active Active
- 2018-12-03 MA MA051043A patent/MA51043A/fr unknown
- 2018-12-03 AU AU2018378200A patent/AU2018378200B2/en active Active
- 2018-12-03 CA CA3084246A patent/CA3084246A1/en active Pending
- 2018-12-03 BR BR112020011111-2A patent/BR112020011111A2/pt unknown
- 2018-12-03 SG SG11202005236QA patent/SG11202005236QA/en unknown
- 2018-12-03 MA MA051042A patent/MA51042A/fr unknown
- 2018-12-03 KR KR1020207019185A patent/KR20200115484A/ko not_active Ceased
- 2018-12-03 MX MX2020005765A patent/MX2020005765A/es unknown
-
2020
- 2020-06-01 IL IL275031A patent/IL275031A/en unknown
-
2022
- 2022-09-12 US US17/931,391 patent/US20230026180A1/en active Pending
-
2023
- 2023-08-18 JP JP2023133670A patent/JP7620676B2/ja active Active
-
2025
- 2025-01-10 JP JP2025003895A patent/JP2025072378A/ja active Pending
- 2025-05-13 AU AU2025203455A patent/AU2025203455A1/en active Pending
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