EA202091335A1 - Ограниченные hla класса i t-клеточные рецепторы против мутантного ras - Google Patents

Ограниченные hla класса i t-клеточные рецепторы против мутантного ras

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Publication number
EA202091335A1
EA202091335A1 EA202091335A EA202091335A EA202091335A1 EA 202091335 A1 EA202091335 A1 EA 202091335A1 EA 202091335 A EA202091335 A EA 202091335A EA 202091335 A EA202091335 A EA 202091335A EA 202091335 A1 EA202091335 A1 EA 202091335A1
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Prior art keywords
mutant ras
hla class
cell receptors
against mutant
tcr
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EA202091335A
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English (en)
Inventor
Рами Йозеф
Йон-Чэнь Лу
Гал Кафри
Стивен А. Розенберг
Original Assignee
Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез
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Application filed by Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез filed Critical Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез
Publication of EA202091335A1 publication Critical patent/EA202091335A1/ru

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    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464454—Enzymes
    • A61K39/464464—GTPases, e.g. Ras or Rho
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
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Abstract

Раскрыт выделенный или очищенный Т-клеточный рецептор (TCR), где данный TCR обладает антигенной специфичностью в отношении мутантной аминокислотной последовательности RAS, презентируемой молекулой человеческого лейкоцитарного антигена (HLA) класса I. Также предложены родственные полипептиды и белки, а также родственные нуклеиновые кислоты, рекомбинантные экспрессионные векторы, клетки-хозяева, популяции клеток и фармацевтические композиции. Также раскрыты способы выявления наличия у млекопитающего рака и способы лечения или предупреждения рака у млекопитающего.
EA202091335A 2017-12-04 2018-12-03 Ограниченные hla класса i t-клеточные рецепторы против мутантного ras EA202091335A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762594244P 2017-12-04 2017-12-04
PCT/US2018/063581 WO2019112941A1 (en) 2017-12-04 2018-12-03 Hla class i-restricted t cell receptors against mutated ras

Publications (1)

Publication Number Publication Date
EA202091335A1 true EA202091335A1 (ru) 2020-10-15

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EA202091335A EA202091335A1 (ru) 2017-12-04 2018-12-03 Ограниченные hla класса i t-клеточные рецепторы против мутантного ras

Country Status (14)

Country Link
US (2) US11466071B2 (ru)
EP (1) EP3720478A1 (ru)
JP (2) JP7385566B2 (ru)
KR (1) KR20200115484A (ru)
AU (1) AU2018378200A1 (ru)
BR (1) BR112020011111A2 (ru)
CA (1) CA3084246A1 (ru)
CR (1) CR20200287A (ru)
EA (1) EA202091335A1 (ru)
IL (1) IL275031A (ru)
MA (2) MA51042A (ru)
MX (1) MX2020005765A (ru)
SG (1) SG11202005236QA (ru)
WO (1) WO2019112941A1 (ru)

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
US11807662B2 (en) 2017-05-16 2023-11-07 The Johns Hopkins University MANAbodies and methods of using
CN113631172A (zh) * 2019-01-25 2021-11-09 宾夕法尼亚大学理事会 用于靶向突变型ras的组合物和方法
CA3130618A1 (en) * 2019-02-20 2020-08-27 Fred Hutchinson Cancer Research Center Binding proteins specific for ras neoantigens and uses thereof
EP3760217A1 (en) * 2019-07-01 2021-01-06 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Cd5 specific t cell receptor cell or gene therapy
CN112646024B (zh) * 2019-10-10 2023-03-24 香雪生命科学技术（广东）有限公司 一种识别kras突变的t细胞受体及其编码序列
CN112759641B (zh) * 2019-11-01 2023-01-20 香雪生命科学技术（广东）有限公司 一种识别Kras G12V的高亲和力TCR
IL295252A (en) * 2020-02-12 2022-10-01 Us Health Human leukocyte antigen type i-restricted t-cell receptors against ras with the g12d mutation
KR20220143875A (ko) * 2020-02-14 2022-10-25 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 G12v 돌연변이를 갖는 ras에 대한 hla 클래스 i-제한된 t 세포 수용체
KR20220143939A (ko) * 2020-02-26 2022-10-25 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 G12v 돌연변이를 갖는 ras에 대한 hla 클래스 ii-제한된 t 세포 수용체
CA3194229A1 (en) * 2020-10-02 2022-04-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class ii-restricted dq t cell receptors against ras with g13d mutation
KR102488353B1 (ko) * 2020-10-08 2023-01-12 부산대학교 산학협력단 돌연변이 kras를 표적하는 펩타이드 및 이의 용도
WO2022183167A1 (en) 2021-02-25 2022-09-01 Alaunos Therapeutics, Inc. Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof
JP2024520427A (ja) * 2021-05-25 2024-05-24 メモリアル スローン ケタリング キャンサー センター Ｒａｓ変異を標的とするｔ細胞受容体およびその使用
CN118574843A (zh) 2022-01-21 2024-08-30 T-Knife 股份有限公司 以可检测的亲和力结合特异性肽的抗原识别构建体和对kras具有抗原特异性的t细胞受体以及相应的核酸序列、载体、宿主细胞、药物组合物和试剂盒
WO2023150562A1 (en) 2022-02-01 2023-08-10 Alaunos Therapeutics, Inc. Methods for activation and expansion of t cells
CN115850444A (zh) * 2022-09-15 2023-03-28 重庆医科大学 Tcr或其抗原结合片段及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003265948B8 (en) 2002-09-06 2009-09-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
EP2619223B1 (en) * 2010-09-21 2019-04-10 The U.S.A. as represented by the Secretary, Department of Health and Human Services Anti-ssx-2 t cell receptors and related materials and methods of use
WO2012129201A1 (en) 2011-03-22 2012-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
WO2016085904A1 (en) 2014-11-26 2016-06-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-mutated kras t cell receptors
SG10201913868XA (en) 2015-09-15 2020-03-30 The United States Of America As Represented By The Secretary T cell receptors recognizing hla-cw8 restricted mutated kras
EP3394092A1 (en) 2015-12-23 2018-10-31 Fred Hutchinson Cancer Research Center High affinity t cell receptors and uses thereof
EA201891459A1 (ru) * 2015-12-23 2018-11-30 Медиджин Иммьюнотерапиз Гмбх Новое поколение антигенспецифических tcr
US20210052642A1 (en) * 2017-12-04 2021-02-25 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Methods of enriching cell populations for cancer-specific t cells using in vitro stimulation of memory t cells

Also Published As

Publication number Publication date
IL275031A (en) 2020-07-30
SG11202005236QA (en) 2020-07-29
BR112020011111A2 (pt) 2020-11-17
JP7385566B2 (ja) 2023-11-22
MA51042A (fr) 2020-10-14
JP2021505136A (ja) 2021-02-18
KR20200115484A (ko) 2020-10-07
MX2020005765A (es) 2020-09-25
JP2023175703A (ja) 2023-12-12
CR20200287A (es) 2020-11-11
US11466071B2 (en) 2022-10-11
WO2019112941A1 (en) 2019-06-13
EP3720478A1 (en) 2020-10-14
CN111836638A (zh) 2020-10-27
MA51043A (fr) 2020-10-14
US20210079058A1 (en) 2021-03-18
CA3084246A1 (en) 2019-06-13
US20230026180A1 (en) 2023-01-26
AU2018378200A1 (en) 2020-07-02

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