KR20200115484A - 돌연변이 ras에 대한 hla 클래스 i-제한 t 세포 수용체 - Google Patents

돌연변이 ras에 대한 hla 클래스 i-제한 t 세포 수용체 Download PDF

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KR20200115484A
KR20200115484A KR1020207019185A KR20207019185A KR20200115484A KR 20200115484 A KR20200115484 A KR 20200115484A KR 1020207019185 A KR1020207019185 A KR 1020207019185A KR 20207019185 A KR20207019185 A KR 20207019185A KR 20200115484 A KR20200115484 A KR 20200115484A
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라미 요셉
용-천 루
갈 카프리
스티븐 에이 로젠버그
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더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈
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    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
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    • A—HUMAN NECESSITIES
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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KR1020207019185A 2017-12-04 2018-12-03 돌연변이 ras에 대한 hla 클래스 i-제한 t 세포 수용체 Ceased KR20200115484A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762594244P 2017-12-04 2017-12-04
US62/594,244 2017-12-04
PCT/US2018/063581 WO2019112941A1 (en) 2017-12-04 2018-12-03 Hla class i-restricted t cell receptors against mutated ras

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KR20200115484A true KR20200115484A (ko) 2020-10-07

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US (2) US11466071B2 (https=)
EP (1) EP3720478A1 (https=)
JP (3) JP7385566B2 (https=)
KR (1) KR20200115484A (https=)
CN (2) CN119162251A (https=)
AU (2) AU2018378200B2 (https=)
BR (1) BR112020011111A2 (https=)
CA (1) CA3084246A1 (https=)
CR (1) CR20200287A (https=)
EA (1) EA202091335A1 (https=)
IL (1) IL275031A (https=)
MA (2) MA51043A (https=)
MX (1) MX2020005765A (https=)
SG (1) SG11202005236QA (https=)
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KR20220046957A (ko) * 2020-10-08 2022-04-15 부산대학교 산학협력단 돌연변이 kras를 표적하는 펩타이드 및 이의 용도

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US11807662B2 (en) 2017-05-16 2023-11-07 The Johns Hopkins University MANAbodies and methods of using
KR20210119468A (ko) * 2019-01-25 2021-10-05 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 돌연변이체 ras를 표적화하기 위한 조성물 및 방법
WO2020172332A1 (en) * 2019-02-20 2020-08-27 Fred Hutchinson Cancer Research Center Binding proteins specific for ras neoantigens and uses thereof
EP3760217A1 (en) * 2019-07-01 2021-01-06 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Cd5 specific t cell receptor cell or gene therapy
CN112646024B (zh) * 2019-10-10 2023-03-24 香雪生命科学技术（广东）有限公司 一种识别kras突变的t细胞受体及其编码序列
CN112759641B (zh) * 2019-11-01 2023-01-20 香雪生命科学技术（广东）有限公司 一种识别Kras G12V的高亲和力TCR
US20230080742A1 (en) * 2020-02-12 2023-03-16 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Hla class i-restricted t cell receptors against ras with g12d mutation
AU2021220957A1 (en) * 2020-02-14 2022-09-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HLA class I-restricted T cell receptors against ras with G12V mutation
TWI900533B (zh) * 2020-02-26 2025-10-11 美國衛生與公眾服務部 針對含有ｇ１２ｖ突變之ｒａｓ之ｈｌａ第ｉｉ類限制性ｔ細胞受體
CN116348484A (zh) * 2020-07-16 2023-06-27 美国卫生和人力服务部 针对含有g12v突变的ras的hla-ii类限制性drb t细胞受体
TW202540156A (zh) * 2020-10-02 2025-10-16 美國衛生與公眾服務部 針對含有g13d突變之ras之hla第ii類限制性dq t細胞受體
US20240000834A1 (en) * 2020-11-24 2024-01-04 Shanghai GenBase Biotechnology Co., Ltd. Ras mutant epitope peptide and t cell receptor recognizing ras mutant
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EP4347639A4 (en) * 2021-05-25 2025-08-06 Memorial Sloan Kettering Cancer Center T CELL RECEPTORS TARGETING RAS MUTATIONS AND THEIR USES
JP2025504883A (ja) 2022-01-21 2025-02-19 テ－クニフェ ゲーエムベーハー 決定可能な親和性で特定のペプチドを結合する抗原認識コンストラクト、およびｋｒａｓに抗原特異性を有するｔ細胞レセプター、ならびに、対応する核酸配列、ベクター、宿主細胞、医薬組成物、およびキット
US20250145950A1 (en) 2022-02-01 2025-05-08 Alaunos Therapeutics, Inc. Methods for Activation and Expansion of T Cells
CN117264043B (zh) * 2022-06-14 2024-05-10 上海镔铁生物科技有限责任公司 靶向kras g12v突变多肽的t细胞受体及其用途
CN115850444B (zh) * 2022-09-15 2025-01-28 重庆医科大学 Tcr或其抗原结合片段及其应用
CN115960204B (zh) * 2022-11-04 2023-08-25 新景智源生物科技(苏州)有限公司 Kras_g12v突变抗原特异性tcr及其与cd8共表达重定向cd4 t细胞
CN118852452A (zh) * 2023-04-28 2024-10-29 北京鼎成肽源生物技术有限公司 靶向kras g12突变的tcr分子和细胞及其应用
CN118909132A (zh) * 2023-05-06 2024-11-08 北京鼎成肽源生物技术有限公司 靶向kras g12v突变的tcr分子和细胞及其应用
WO2025056681A1 (en) * 2023-09-15 2025-03-20 Medigene Immunotherapies Gmbh T-CELL RECEPTOR AGAINST mKRAS7-16 G12V AND G12C
WO2025056672A1 (en) * 2023-09-15 2025-03-20 Medigene Immunotherapies Gmbh T-CELL RECEPTOR VARIANT AGAINST mKRAS7-16 G12V
EP4570263A1 (en) * 2023-12-15 2025-06-18 Genovie AB Tcrs recognizing g12v mutated ras and uses thereof
WO2025125590A2 (en) * 2023-12-15 2025-06-19 Genovie Ab Tcr recognizing g12v mutated ras and uses thereof
WO2026024602A2 (en) * 2024-07-22 2026-01-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors against ras with g12d, g12v, g13d or q61r mutation
CN119350472B (zh) * 2024-12-25 2025-04-04 北京可瑞生物科技有限公司 修饰的靶向kras g12v的t细胞受体或其片段以及用途

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AU2003265948B8 (en) 2002-09-06 2009-09-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
CN103124740B (zh) * 2010-09-21 2015-09-02 美国卫生和人力服务部 抗-ssx-2t细胞受体和相关材料及使用方法
WO2012129201A1 (en) 2011-03-22 2012-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
MX384919B (es) * 2014-11-26 2025-03-14 Us Health Receptores de células t de kras anti-mutado.
JP7185524B2 (ja) 2015-09-15 2022-12-07 アメリカ合衆国 Ｈｌａ－ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体
HUE053674T2 (hu) * 2015-12-23 2021-07-28 Medigene Immunotherapies Gmbh Antigén-specifikus TCR receptorok új generációja
US11026969B2 (en) * 2015-12-23 2021-06-08 Fred Hutchinson Cancer Research Center High affinity T cell receptors and uses thereof
US12221627B2 (en) * 2017-12-04 2025-02-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of enriching cell populations for cancer-specific T cells using in vitro stimulation of memory T cells

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Publication number Priority date Publication date Assignee Title
KR20220046957A (ko) * 2020-10-08 2022-04-15 부산대학교 산학협력단 돌연변이 kras를 표적하는 펩타이드 및 이의 용도

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US20230026180A1 (en) 2023-01-26
MA51043A (fr) 2020-10-14
AU2025203455A1 (en) 2025-06-05
JP7620676B2 (ja) 2025-01-23
CN111836638A (zh) 2020-10-27
CA3084246A1 (en) 2019-06-13
SG11202005236QA (en) 2020-07-29
US11466071B2 (en) 2022-10-11
BR112020011111A2 (pt) 2020-11-17
IL275031A (en) 2020-07-30
EA202091335A1 (ru) 2020-10-15
JP2025072378A (ja) 2025-05-09
US20210079058A1 (en) 2021-03-18
CN111836638B (zh) 2024-10-29
AU2018378200B2 (en) 2025-02-27
AU2018378200A1 (en) 2020-07-02
JP2023175703A (ja) 2023-12-12
JP2021505136A (ja) 2021-02-18
EP3720478A1 (en) 2020-10-14
JP7385566B2 (ja) 2023-11-22
CR20200287A (es) 2020-11-11
CN119162251A (zh) 2024-12-20
MA51042A (fr) 2020-10-14
WO2019112941A1 (en) 2019-06-13
AU2025203455A9 (en) 2026-03-12
MX2020005765A (es) 2020-09-25

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