JPWO2022035752A5 - - Google Patents

Info

Publication number

JPWO2022035752A5

JPWO2022035752A5 JP2023508551A JP2023508551A JPWO2022035752A5 JP WO2022035752 A5 JPWO2022035752 A5 JP WO2022035752A5 JP 2023508551 A JP2023508551 A JP 2023508551A JP 2023508551 A JP2023508551 A JP 2023508551A JP WO2022035752 A5 JPWO2022035752 A5 JP WO2022035752A5

Authority

JP

Japan

Prior art keywords

compound

pharma

compound according

acceptable salt

pharmaceutical composition

Prior art date

2024-08-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims description 22
• 206010017533 Fungal infection Diseases 0.000 claims description 6
• 208000031888 Mycoses Diseases 0.000 claims description 6
• 239000008194 pharmaceutical composition Substances 0.000 claims description 6
• 150000003839 salts Chemical class 0.000 claims description 6
• 239000003814 drug Substances 0.000 claims description 4
• 239000006207 intravenous dosage form Substances 0.000 claims description 2
• 238000004519 manufacturing process Methods 0.000 claims description 2
• 239000006186 oral dosage form Substances 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 3
• 229940126214 compound 3 Drugs 0.000 description 5
• 241000699670 Mus sp. Species 0.000 description 4
• 238000000034 method Methods 0.000 description 3
• ITRJWOMZKQRYTA-RFZYENFJSA-N Cortisone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)CC2=O ITRJWOMZKQRYTA-RFZYENFJSA-N 0.000 description 2
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
• 229960003290 cortisone acetate Drugs 0.000 description 2
• 229960004397 cyclophosphamide Drugs 0.000 description 2
• 208000015181 infectious disease Diseases 0.000 description 2
• 230000004083 survival effect Effects 0.000 description 2
• 206010061598 Immunodeficiency Diseases 0.000 description 1
• 208000029462 Immunodeficiency disease Diseases 0.000 description 1
• 206010024264 Lethargy Diseases 0.000 description 1
• 241001465754 Metazoa Species 0.000 description 1
• 229940098178 ambisome Drugs 0.000 description 1
• APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 230000007813 immunodeficiency Effects 0.000 description 1
• 208000004235 neutropenia Diseases 0.000 description 1