JPWO2021180774A5 - - Google Patents

Info

Publication number

JPWO2021180774A5

JPWO2021180774A5 JP2022554500A JP2022554500A JPWO2021180774A5 JP WO2021180774 A5 JPWO2021180774 A5 JP WO2021180774A5 JP 2022554500 A JP2022554500 A JP 2022554500A JP 2022554500 A JP2022554500 A JP 2022554500A JP WO2021180774 A5 JPWO2021180774 A5 JP WO2021180774A5

Authority

JP

Japan

Prior art keywords

alkyl

different

pharmaceutically acceptable

optionally substituted

same

Prior art date

2024-03-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 125000000217 alkyl group Chemical group 0.000 claims 35
• 150000001875 compounds Chemical class 0.000 claims 27
• 150000003839 salts Chemical class 0.000 claims 27
• 239000012453 solvate Substances 0.000 claims 27
• 229910052736 halogen Inorganic materials 0.000 claims 22
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 18
• 125000005843 halogen group Chemical group 0.000 claims 15
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 14
• -1 pyrimidazyl Chemical group 0.000 claims 10
• 229910052799 carbon Inorganic materials 0.000 claims 9
• 229910052739 hydrogen Inorganic materials 0.000 claims 8
• 150000002367 halogens Chemical class 0.000 claims 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 150000004677 hydrates Chemical class 0.000 claims 6
• 125000000623 heterocyclic group Chemical group 0.000 claims 5
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
• 201000010099 disease Diseases 0.000 claims 4
• 229920006395 saturated elastomer Polymers 0.000 claims 4
• 125000001424 substituent group Chemical group 0.000 claims 4
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 3
• 208000030090 Acute Disease Diseases 0.000 claims 3
• 208000017667 Chronic Disease Diseases 0.000 claims 3
• 125000003342 alkenyl group Chemical group 0.000 claims 3
• 125000004432 carbon atom Chemical group C* 0.000 claims 3
• 230000001684 chronic effect Effects 0.000 claims 3
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
• 229910052731 fluorine Inorganic materials 0.000 claims 3
• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
• WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims 3
• 229910052801 chlorine Inorganic materials 0.000 claims 2
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 208000015122 neurodegenerative disease Diseases 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 150000003852 triazoles Chemical class 0.000 claims 2
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• DTMQNMCSCKAQAJ-DBGHOVABSA-N C(F)(C1=C(Cl)C=C(OCC(=O)N[C@H]2CO[C@@H](OC2)C2=NN=C(N3CC(OC(F)(F)F)C3)O2)C=C1)F Chemical compound C(F)(C1=C(Cl)C=C(OCC(=O)N[C@H]2CO[C@@H](OC2)C2=NN=C(N3CC(OC(F)(F)F)C3)O2)C=C1)F DTMQNMCSCKAQAJ-DBGHOVABSA-N 0.000 claims 1
• JGLMVXWAHNTPRF-CMDGGOBGSA-N CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O Chemical compound CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O JGLMVXWAHNTPRF-CMDGGOBGSA-N 0.000 claims 1
• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• 208000035473 Communicable disease Diseases 0.000 claims 1
• 206010016654 Fibrosis Diseases 0.000 claims 1
• WRYCSMQKUKOKBP-UHFFFAOYSA-N Imidazolidine Chemical compound C1CNCN1 WRYCSMQKUKOKBP-UHFFFAOYSA-N 0.000 claims 1
• 201000006347 Intellectual Disability Diseases 0.000 claims 1
• 208000032382 Ischaemic stroke Diseases 0.000 claims 1
• 208000023178 Musculoskeletal disease Diseases 0.000 claims 1
• WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
• 230000006793 arrhythmia Effects 0.000 claims 1
• 206010003119 arrhythmia Diseases 0.000 claims 1
• 125000004429 atom Chemical group 0.000 claims 1
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
• 125000002393 azetidinyl group Chemical group 0.000 claims 1
• 150000001602 bicycloalkyls Chemical group 0.000 claims 1
• 230000000975 bioactive effect Effects 0.000 claims 1
• 229910052794 bromium Inorganic materials 0.000 claims 1
• VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical group C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 claims 1
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 208000030533 eye disease Diseases 0.000 claims 1
• 230000004761 fibrosis Effects 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 210000003734 kidney Anatomy 0.000 claims 1
• 208000036546 leukodystrophy Diseases 0.000 claims 1
• 210000004185 liver Anatomy 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 208000030159 metabolic disease Diseases 0.000 claims 1
• 208000010125 myocardial infarction Diseases 0.000 claims 1
• 125000001624 naphthyl group Chemical group 0.000 claims 1
• 230000001613 neoplastic effect Effects 0.000 claims 1
• 208000004296 neuralgia Diseases 0.000 claims 1
• 230000004770 neurodegeneration Effects 0.000 claims 1
• 208000021722 neuropathic pain Diseases 0.000 claims 1
• 210000000056 organ Anatomy 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 239000001301 oxygen Substances 0.000 claims 1
• 125000004430 oxygen atom Chemical group O* 0.000 claims 1
• 125000003373 pyrazinyl group Chemical group 0.000 claims 1
• 125000004076 pyridyl group Chemical group 0.000 claims 1
• 230000003938 response to stress Effects 0.000 claims 1
• 125000006413 ring segment Chemical group 0.000 claims 1
• 208000020431 spinal cord injury Diseases 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 238000003419 tautomerization reaction Methods 0.000 claims 1
• 125000000464 thioxo group Chemical group S=* 0.000 claims 1