JPWO2021180237A5 - - Google Patents
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- JPWO2021180237A5 JPWO2021180237A5 JP2022554328A JP2022554328A JPWO2021180237A5 JP WO2021180237 A5 JPWO2021180237 A5 JP WO2021180237A5 JP 2022554328 A JP2022554328 A JP 2022554328A JP 2022554328 A JP2022554328 A JP 2022554328A JP WO2021180237 A5 JPWO2021180237 A5 JP WO2021180237A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- peg
- cells
- damage
- extracellular vesicles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 206010061218 Inflammation Diseases 0.000 claims 6
- 230000006378 damage Effects 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 230000004054 inflammatory process Effects 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 230000002458 infectious effect Effects 0.000 claims 3
- 210000001082 somatic cell Anatomy 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 206010069351 acute lung injury Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003636 conditioned culture medium Substances 0.000 claims 2
- 210000000795 conjunctiva Anatomy 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 239000002244 precipitate Substances 0.000 claims 2
- 210000002345 respiratory system Anatomy 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 210000002821 alveolar epithelial cell Anatomy 0.000 claims 1
- 230000006472 autoimmune response Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 230000005779 cell damage Effects 0.000 claims 1
- 208000037887 cell injury Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 230000001146 hypoxic effect Effects 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 230000008595 infiltration Effects 0.000 claims 1
- 238000001764 infiltration Methods 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000003928 nasal cavity Anatomy 0.000 claims 1
- 239000007923 nasal drop Substances 0.000 claims 1
- 229940100662 nasal drops Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000003860 storage Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010177541.7 | 2020-03-13 | ||
| CN202010177541.7A CN113384597A (zh) | 2020-03-13 | 2020-03-13 | 含人体细胞衍生的细胞膜外囊泡的雾化吸入制剂、制法及其应用 |
| PCT/CN2021/080869 WO2021180237A1 (zh) | 2020-03-13 | 2021-03-15 | 含人体细胞衍生的细胞膜外囊泡的雾化吸入制剂、制法及其应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023516458A JP2023516458A (ja) | 2023-04-19 |
| JP2023516458A5 JP2023516458A5 (https=) | 2024-03-27 |
| JPWO2021180237A5 true JPWO2021180237A5 (https=) | 2024-03-27 |
Family
ID=77616331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022554328A Pending JP2023516458A (ja) | 2020-03-13 | 2021-03-15 | ヒト細胞由来細胞外小胞を含有する噴霧吸入製剤、その調製方法及び使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230120324A1 (https=) |
| EP (1) | EP4134105A4 (https=) |
| JP (1) | JP2023516458A (https=) |
| CN (1) | CN113384597A (https=) |
| AU (1) | AU2021234601A1 (https=) |
| WO (1) | WO2021180237A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230050813A1 (en) | 2020-01-13 | 2023-02-16 | Carmine Therapeutics Pte. Ltd. | Nucleic acid loaded red blood cell extracellular vesicles |
| CN115212230B (zh) * | 2021-04-21 | 2024-12-27 | 时比曼生物科技(上海)有限公司 | 含有干细胞胞外囊泡的药物组合物及其在呼吸道炎症治疗中的应用 |
| CN114306621B (zh) * | 2021-12-20 | 2023-10-20 | 苏州大学 | 一种携带核酸药物的细胞外泌体及其制备方法与在免疫治疗中的应用 |
| WO2023123216A1 (zh) * | 2021-12-30 | 2023-07-06 | 中山大学 | 囊泡在制备治疗肺部疾病的药物中的应用 |
| CN114480260B (zh) * | 2022-01-24 | 2024-02-09 | 同济大学 | 一种成体肺干细胞外泌体及其制备方法和应用 |
| CN114099481B (zh) * | 2022-01-28 | 2022-05-24 | 深圳湾实验室 | 雾化吸入型糖皮质激素纳米药物及其制备方法和应用 |
| CN114432341B (zh) * | 2022-02-18 | 2024-02-06 | 徐州医科大学 | 一种用于预防和治疗高原肺水肿的间充质干细胞杂化胞外囊泡的制备方法 |
| CN114652703B (zh) * | 2022-03-14 | 2023-07-04 | 陕西兰医维生物科技有限公司 | 雾化吸入功能性细胞外囊泡在改善急性肺损伤中的应用 |
| CN115414387A (zh) * | 2022-08-12 | 2022-12-02 | 四川大学华西医院 | 一种用于治疗肺纤维化的医疗包 |
| WO2024118073A1 (en) * | 2022-11-30 | 2024-06-06 | Carmine Therapeutics Pte. Ltd. | Pulmonary delivery of nebulized preparations of red blood cell extracellular vesicles (rbcevs) |
| US11944742B1 (en) * | 2023-06-08 | 2024-04-02 | Microneb Tech Holdings, Inc. | Apparatus, methods, and systems for administering a medication to an animal |
| JP7730003B2 (ja) * | 2023-02-10 | 2025-08-27 | 中国▲医▼薬大学 | 細胞外小胞／エクソソーム保存溶液及びその混合溶液 |
| CN119097599B (zh) * | 2024-09-09 | 2025-04-18 | 北京青藤谷禧干细胞科技研究院有限公司 | 一种含干细胞外泌体的雾化剂及其制备方法和应用 |
| CN119606929A (zh) * | 2024-12-02 | 2025-03-14 | 浙江大学 | 一种基于细胞膜的载核酸药物生物囊泡吸入制剂的制备方法及其产品和应用 |
| CN120284902A (zh) * | 2025-04-29 | 2025-07-11 | 洛阳市中心医院 | 一种仿生囊泡制剂及其制备方法与应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5667180B2 (ja) * | 2009-07-01 | 2015-02-12 | イオン メディックス インコーポレイテッド | 哺乳類の有核細胞に由来するマイクロベシクル及びその用途 |
| CA2829586C (en) * | 2011-03-11 | 2021-03-02 | Children's Medical Center Corporation | Methods and compositions relating to mesenchymal stem cell exosomes |
| CN105209881B (zh) * | 2013-03-13 | 2021-01-22 | 迈阿密大学 | 从细胞培养上清液和生物流体分离并纯化微泡的方法 |
| US10143709B2 (en) * | 2014-05-06 | 2018-12-04 | Indiana University Research And Technology Corporation | Use of ASC and ASC-CM to treat ARDS, SARS, and MERS |
| CN105267240B (zh) * | 2014-12-16 | 2019-05-14 | 天津医科大学眼科医院 | 间充质干细胞来源的外泌体的用途 |
| CN105796599A (zh) * | 2014-12-29 | 2016-07-27 | 西比曼生物科技（上海）有限公司 | 一种用于治疗哮喘的脂肪间充质祖细胞复合物 |
| EP3270984A4 (en) * | 2015-03-16 | 2019-04-17 | Duncan Ross | TREATMENT METHOD WITH MEMBRANE-INCLUDED VESICLE |
| WO2018071677A1 (en) * | 2016-10-13 | 2018-04-19 | Vbc Holdings Llc | Medical uses of exosomes |
| CN110072991A (zh) * | 2016-10-13 | 2019-07-30 | Vbc控股有限责任公司 | 来源于发炎的细胞或组织的抗炎外泌体 |
| WO2018109525A1 (en) * | 2016-12-14 | 2018-06-21 | Università Degli Studi Di Padova | New anti-angiogenic extracellurlar vesicles |
| CN107137426A (zh) * | 2017-05-17 | 2017-09-08 | 天津普瑞赛尔生物科技有限公司 | 含人间充质干细胞外泌体提取物的矽肺病治疗雾化剂及其制备方法 |
| CA3072562A1 (en) * | 2017-08-15 | 2019-02-21 | Children's Medical Center Corporation | Purified mesenchymal stem cell exosomes and uses thereof |
| CN109419770A (zh) * | 2018-03-07 | 2019-03-05 | 厦门艾赛生物科技有限公司 | 一种间充质干细胞外泌体滴眼液及其制备方法和应用 |
| MA53273A (fr) * | 2018-08-10 | 2021-06-16 | Omnispirant Ltd | Vésicules extracellulaires pour inhalation |
| CN109432130A (zh) * | 2018-12-20 | 2019-03-08 | 中科广聚(北京)生物医学技术中心有限公司 | 间充质干细胞外泌体在制备预防和治疗放射性肺损伤的药物中的应用 |
| EP4179069A4 (en) * | 2020-07-09 | 2024-10-02 | Remedy Cell Ltd. | METHODS FOR THE TREATMENT OF ACUTE RESPIRATORY INFLAMMATION AND CYTOKINE STORM SYNDROME |
| WO2022018729A1 (en) * | 2020-07-20 | 2022-01-27 | Brainstorm Cell Therapeutics Ltd. | Methods and compositions for treating lung conditions |
-
2020
- 2020-03-13 CN CN202010177541.7A patent/CN113384597A/zh active Pending
-
2021
- 2021-03-15 WO PCT/CN2021/080869 patent/WO2021180237A1/zh not_active Ceased
- 2021-03-15 AU AU2021234601A patent/AU2021234601A1/en active Pending
- 2021-03-15 EP EP21768139.4A patent/EP4134105A4/en not_active Withdrawn
- 2021-03-15 JP JP2022554328A patent/JP2023516458A/ja active Pending
- 2021-03-15 US US17/910,444 patent/US20230120324A1/en not_active Abandoned
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