CN113384597A - 含人体细胞衍生的细胞膜外囊泡的雾化吸入制剂、制法及其应用 - Google Patents

含人体细胞衍生的细胞膜外囊泡的雾化吸入制剂、制法及其应用 Download PDF

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CN113384597A
CN113384597A CN202010177541.7A CN202010177541A CN113384597A CN 113384597 A CN113384597 A CN 113384597A CN 202010177541 A CN202010177541 A CN 202010177541A CN 113384597 A CN113384597 A CN 113384597A
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cells
pharmaceutical composition
cell
extracellular
vesicle
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戴成祥
李萍
王静
李苏克
雷继刚
陈应炉
宋晓乐
刘必佐
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Shibiman Biotechnology Shanghai Co ltd
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Cellular Biomedicine Group Shanghai Ltd
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Priority to CN202010177541.7A priority Critical patent/CN113384597A/zh
Priority to EP21768139.4A priority patent/EP4134105A4/en
Priority to US17/910,444 priority patent/US20230120324A1/en
Priority to PCT/CN2021/080869 priority patent/WO2021180237A1/zh
Priority to JP2022554328A priority patent/JP2023516458A/ja
Priority to AU2021234601A priority patent/AU2021234601A1/en
Publication of CN113384597A publication Critical patent/CN113384597A/zh
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CN202010177541.7A 2020-03-13 2020-03-13 含人体细胞衍生的细胞膜外囊泡的雾化吸入制剂、制法及其应用 Pending CN113384597A (zh)

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CN202010177541.7A CN113384597A (zh) 2020-03-13 2020-03-13 含人体细胞衍生的细胞膜外囊泡的雾化吸入制剂、制法及其应用
EP21768139.4A EP4134105A4 (en) 2020-03-13 2021-03-15 Atomized inhalation formulation containing human cell-derived extracellular vesicles, preparation method and use thereof
US17/910,444 US20230120324A1 (en) 2020-03-13 2021-03-15 Atomized inhalation formulation containing human cell-derived extracellular vesicles, preparation method and use thereof
PCT/CN2021/080869 WO2021180237A1 (zh) 2020-03-13 2021-03-15 含人体细胞衍生的细胞膜外囊泡的雾化吸入制剂、制法及其应用
JP2022554328A JP2023516458A (ja) 2020-03-13 2021-03-15 ヒト細胞由来細胞外小胞を含有する噴霧吸入製剤、その調製方法及び使用
AU2021234601A AU2021234601A1 (en) 2020-03-13 2021-03-15 Atomized inhalation formulation containing human cell-derived extracellular vesicles, preparation method and use thereof

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CN202010177541.7A CN113384597A (zh) 2020-03-13 2020-03-13 含人体细胞衍生的细胞膜外囊泡的雾化吸入制剂、制法及其应用

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114306621A (zh) * 2021-12-20 2022-04-12 苏州大学 一种携带核酸药物的细胞外泌体及其制备方法与在免疫治疗中的应用
CN114432341A (zh) * 2022-02-18 2022-05-06 徐州医科大学 一种用于预防和治疗高原肺水肿的间充质干细胞杂化胞外囊泡的制备方法
CN114480260A (zh) * 2022-01-24 2022-05-13 同济大学 一种成体肺干细胞外泌体及其制备方法和应用
CN114652703A (zh) * 2022-03-14 2022-06-24 陕西兰医维生物科技有限公司 雾化吸入功能性细胞外囊泡在改善急性肺损伤中的应用
CN115212230A (zh) * 2021-04-21 2022-10-21 西比曼生物科技(上海)有限公司 含有干细胞胞外囊泡的药物组合物及其在呼吸道炎症治疗中的应用
CN115414387A (zh) * 2022-08-12 2022-12-02 四川大学华西医院 一种用于治疗肺纤维化的医疗包
WO2023123216A1 (zh) * 2021-12-30 2023-07-06 中山大学 囊泡在制备治疗肺部疾病的药物中的应用
CN119606929A (zh) * 2024-12-02 2025-03-14 浙江大学 一种基于细胞膜的载核酸药物生物囊泡吸入制剂的制备方法及其产品和应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230050813A1 (en) 2020-01-13 2023-02-16 Carmine Therapeutics Pte. Ltd. Nucleic acid loaded red blood cell extracellular vesicles
CN114099481B (zh) * 2022-01-28 2022-05-24 深圳湾实验室 雾化吸入型糖皮质激素纳米药物及其制备方法和应用
WO2024118073A1 (en) * 2022-11-30 2024-06-06 Carmine Therapeutics Pte. Ltd. Pulmonary delivery of nebulized preparations of red blood cell extracellular vesicles (rbcevs)
US11944742B1 (en) * 2023-06-08 2024-04-02 Microneb Tech Holdings, Inc. Apparatus, methods, and systems for administering a medication to an animal
JP7730003B2 (ja) * 2023-02-10 2025-08-27 中国▲医▼薬大学 細胞外小胞/エクソソーム保存溶液及びその混合溶液
CN119097599B (zh) * 2024-09-09 2025-04-18 北京青藤谷禧干细胞科技研究院有限公司 一种含干细胞外泌体的雾化剂及其制备方法和应用
CN120284902A (zh) * 2025-04-29 2025-07-11 洛阳市中心医院 一种仿生囊泡制剂及其制备方法与应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102596177A (zh) * 2009-07-01 2012-07-18 阿昂梅迪克斯公司 来源于有核哺乳动物细胞的微囊泡及其应用
US20150320801A1 (en) * 2014-05-06 2015-11-12 Indiana University Research And Technology Corp. Use of asc and asc-cm to treat ards, sars, and mers
US20180042847A1 (en) * 2015-03-16 2018-02-15 Duncan ROSS Method of treatment comprising membrane-enclosed vesicle
WO2020030817A1 (en) * 2018-08-10 2020-02-13 Omnispirant Limited Extracellular vesicles for inhalation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2829586C (en) * 2011-03-11 2021-03-02 Children's Medical Center Corporation Methods and compositions relating to mesenchymal stem cell exosomes
CN105209881B (zh) * 2013-03-13 2021-01-22 迈阿密大学 从细胞培养上清液和生物流体分离并纯化微泡的方法
CN105267240B (zh) * 2014-12-16 2019-05-14 天津医科大学眼科医院 间充质干细胞来源的外泌体的用途
CN105796599A (zh) * 2014-12-29 2016-07-27 西比曼生物科技(上海)有限公司 一种用于治疗哮喘的脂肪间充质祖细胞复合物
WO2018071677A1 (en) * 2016-10-13 2018-04-19 Vbc Holdings Llc Medical uses of exosomes
CN110072991A (zh) * 2016-10-13 2019-07-30 Vbc控股有限责任公司 来源于发炎的细胞或组织的抗炎外泌体
WO2018109525A1 (en) * 2016-12-14 2018-06-21 Università Degli Studi Di Padova New anti-angiogenic extracellurlar vesicles
CN107137426A (zh) * 2017-05-17 2017-09-08 天津普瑞赛尔生物科技有限公司 含人间充质干细胞外泌体提取物的矽肺病治疗雾化剂及其制备方法
CA3072562A1 (en) * 2017-08-15 2019-02-21 Children's Medical Center Corporation Purified mesenchymal stem cell exosomes and uses thereof
CN109419770A (zh) * 2018-03-07 2019-03-05 厦门艾赛生物科技有限公司 一种间充质干细胞外泌体滴眼液及其制备方法和应用
CN109432130A (zh) * 2018-12-20 2019-03-08 中科广聚(北京)生物医学技术中心有限公司 间充质干细胞外泌体在制备预防和治疗放射性肺损伤的药物中的应用
EP4179069A4 (en) * 2020-07-09 2024-10-02 Remedy Cell Ltd. METHODS FOR THE TREATMENT OF ACUTE RESPIRATORY INFLAMMATION AND CYTOKINE STORM SYNDROME
WO2022018729A1 (en) * 2020-07-20 2022-01-27 Brainstorm Cell Therapeutics Ltd. Methods and compositions for treating lung conditions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102596177A (zh) * 2009-07-01 2012-07-18 阿昂梅迪克斯公司 来源于有核哺乳动物细胞的微囊泡及其应用
US20150320801A1 (en) * 2014-05-06 2015-11-12 Indiana University Research And Technology Corp. Use of asc and asc-cm to treat ards, sars, and mers
US20180042847A1 (en) * 2015-03-16 2018-02-15 Duncan ROSS Method of treatment comprising membrane-enclosed vesicle
WO2020030817A1 (en) * 2018-08-10 2020-02-13 Omnispirant Limited Extracellular vesicles for inhalation

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
FUJITA Y等: "Clinical application of mesenchymal stem cell-derived extracellular vesicle-based therapeutics for inflammatory lung diseases", 《JOURNAL OF CLINICAL MEDICINE》 *
FUJITA Y等: "Clinical application of mesenchymal stem cell-derived extracellular vesicle-based therapeutics for inflammatory lung diseases", 《JOURNAL OF CLINICAL MEDICINE》, vol. 7, no. 10, 14 October 2018 (2018-10-14), pages 355 - 375, XP055787398, DOI: 10.3390/jcm7100355 *
RIDER, M.A.等: "ExtraPEG: A Polyethylene Glycol-Based Method for the Enrichment of Extracellular Vesicles", 《SCI. REP.》, vol. 6, pages 303 - 317 *
YANG D等: "Progress, opportunity, and perspective on exosome isolation-efforts for efficient exosome-based theranostics", 《THERANOSTICS》, vol. 10, no. 8, pages 3684 - 3707, XP055910383, DOI: 10.7150/thno.41580 *
付小兵: "《付小兵再生医学》", 31 March 2019, 武汉:湖北科学技术出版社, pages: 781 *
张菊芳等: "《现代毛发移植技术》", vol. 1, 31 May 2018, 浙江科学技术出版社, pages: 312 - 313 *
杨诚等: "基于PEG6000富集精液来源外泌体的提取及鉴定", 《南方医科大学学报》, vol. 36, no. 11, pages 1531 *
梁亚会等: "PEG6000快速提取间充质干细胞外泌体", 《空军医学杂志》, vol. 33, no. 3, pages 176 - 179 *
钟玉兰,淦鑫: "间充质干细胞源外泌体在肺部疾病中的应用与作用", 《中国组织工程研究》 *
钟玉兰,淦鑫: "间充质干细胞源外泌体在肺部疾病中的应用与作用", 《中国组织工程研究》, vol. 23, no. 13, 18 October 2019 (2019-10-18), pages 2121 - 2126 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115212230A (zh) * 2021-04-21 2022-10-21 西比曼生物科技(上海)有限公司 含有干细胞胞外囊泡的药物组合物及其在呼吸道炎症治疗中的应用
WO2022222987A1 (zh) * 2021-04-21 2022-10-27 西比曼生物科技(上海)有限公司 含有干细胞胞外囊泡的药物组合物及其在呼吸道炎症治疗中的应用
CN115212230B (zh) * 2021-04-21 2024-12-27 时比曼生物科技(上海)有限公司 含有干细胞胞外囊泡的药物组合物及其在呼吸道炎症治疗中的应用
CN114306621A (zh) * 2021-12-20 2022-04-12 苏州大学 一种携带核酸药物的细胞外泌体及其制备方法与在免疫治疗中的应用
CN114306621B (zh) * 2021-12-20 2023-10-20 苏州大学 一种携带核酸药物的细胞外泌体及其制备方法与在免疫治疗中的应用
WO2023123216A1 (zh) * 2021-12-30 2023-07-06 中山大学 囊泡在制备治疗肺部疾病的药物中的应用
CN114480260B (zh) * 2022-01-24 2024-02-09 同济大学 一种成体肺干细胞外泌体及其制备方法和应用
CN114480260A (zh) * 2022-01-24 2022-05-13 同济大学 一种成体肺干细胞外泌体及其制备方法和应用
CN114432341A (zh) * 2022-02-18 2022-05-06 徐州医科大学 一种用于预防和治疗高原肺水肿的间充质干细胞杂化胞外囊泡的制备方法
CN114432341B (zh) * 2022-02-18 2024-02-06 徐州医科大学 一种用于预防和治疗高原肺水肿的间充质干细胞杂化胞外囊泡的制备方法
CN114652703A (zh) * 2022-03-14 2022-06-24 陕西兰医维生物科技有限公司 雾化吸入功能性细胞外囊泡在改善急性肺损伤中的应用
CN115414387A (zh) * 2022-08-12 2022-12-02 四川大学华西医院 一种用于治疗肺纤维化的医疗包
CN119606929A (zh) * 2024-12-02 2025-03-14 浙江大学 一种基于细胞膜的载核酸药物生物囊泡吸入制剂的制备方法及其产品和应用

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